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Melyssa Bratton

TitleCell, Molecular Biology, and Bioinformatics Core Manager
InstitutionXavier University of Louisiana
Address1 Drexel Dr
New Orleans LA 70125
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    I obtained my PhD in biochemistry in 2000. My first postdoctoral position was in a hypertension lab working on the mineralocorticoid receptor. In this lab, I was introduced to nuclear receptor biology and physiology. In 2005 I moved to Tulane University in New Orleans to work on another nuclear receptor, the estrogen receptor (ER). Specifically, I was interested in the effects of endocrine disrupting chemicals’ effects on ER biology and what roles these chemicals might play in ER-dependent breast cancer. I was also involved in projects concerning drug resistance in breast cancer and in dissecting molecular mechanisms of drug resistance and triple negative breast cancer. My current work focuses on mutations within the ER that render it constitutively active. I am particularly interested in understanding the mechanisms through which breast cancer cells either acquire these mutations. I believe my previous work elucidating molecular mechanisms of ER crosstalk with cellular pathways gives me a firm foundation to pursue my current work.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Sabol RA, Beighley A, Giacomelli P, Wise RM, Harrison MAA, O'Donnnell BA, Sullivan BN, Lampenfeld JD, Matossian MD, Bratton MR, Wang G, Collins-Burow BM, Burow ME, Bunnell BA. Obesity-Altered Adipose Stem Cells Promote ER? Breast Cancer Metastasis through Estrogen Independent Pathways. Int J Mol Sci. 2019 Mar 20; 20(6). PMID: 30897853.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    2. Thomas-Porch C, Li J, Zanata F, Martin EC, Pashos N, Genemaras K, Poche JN, Totaro NP, Bratton MR, Gaupp D, Frazier T, Wu X, Ferreira LM, Tian W, Wang G, Bunnell BA, Flynn L, Hayes D, Gimble JM. Comparative proteomic analyses of human adipose extracellular matrices decellularized using alternative procedures. J Biomed Mater Res A. 2018 09; 106(9):2481-2493. PMID: 29693792.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    3. Guo S, Zhang C, Bratton M, Mottamal M, Liu J, Ma P, Zheng S, Zhong Q, Yang L, Wiese TE, Wu Y, Ellis MJ, Matossian M, Burow ME, Miele L, Houtman R, Wang G. ZB716, a steroidal selective estrogen receptor degrader (SERD), is orally efficacious in blocking tumor growth in mouse xenograft models. Oncotarget. 2018 Jan 23; 9(6):6924-6937. PMID: 29467940.
      Citations: 2     Fields:    
    4. Toro TB, Painter RG, Haynes RA, Glotser EY, Bratton MR, Bryant JR, Nichols KA, Matthew-Onabanjo AN, Matthew AN, Bratcher DR, Perry CD, Watt TJ. Purification of metal-dependent lysine deacetylases with consistently high activity. Protein Expr Purif. 2018 Jan; 141:1-6. PMID: 28843507.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    5. Bateman ME, Strong AL, Hunter RS, Bratton MR, Komati R, Sridhar J, Riley KE, Wang G, Hayes DJ, Boue SM, Burow ME, Bunnell BA. Osteoinductive effects of glyceollins on adult mesenchymal stromal/stem cells from adipose tissue and bone marrow. Phytomedicine. 2017 Apr 15; 27:39-51. PMID: 28314478.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    6. Liu J, Zheng S, Guo S, Zhang C, Zhong Q, Zhang Q, Ma P, Skripnikova EV, Bratton MR, Wiese TE, Wang G. Rational Design of a Boron-Modified Triphenylethylene (GLL398) as an Oral Selective Estrogen Receptor Downregulator. ACS Med Chem Lett. 2017 Jan 12; 8(1):102-106. PMID: 28105283.
    7. Liu J, Zheng S, Akerstrom VL, Yuan C, Ma Y, Zhong Q, Zhang C, Zhang Q, Guo S, Ma P, Skripnikova EV, Bratton MR, Pannuti A, Miele L, Wiese TE, Wang G. Fulvestrant-3 Boronic Acid (ZB716): An Orally Bioavailable Selective Estrogen Receptor Downregulator (SERD). J Med Chem. 2016 09 08; 59(17):8134-40. PMID: 27529700.
      Citations: 10     Fields:    Translation:AnimalsCells
    8. Schroeder RL, Goyal N, Bratton M, Townley I, Pham NA, Tram P, Stone T, Geathers J, Nguyen K, Sridhar J. Identification of quinones as novel PIM1 kinase inhibitors. Bioorg Med Chem Lett. 2016 07 01; 26(13):3187-3191. PMID: 27173800.
      Citations: 2     Fields:    Translation:HumansCells
    9. Chimezie C, Ewing A, Schexnayder C, Bratton M, Glotser E, Skripnikova E, Sá P, Boué S, Stratford RE. Glyceollin Effects on MRP2 and BCRP in Caco-2 Cells, and Implications for Metabolic and Transport Interactions. J Pharm Sci. 2016 Feb; 105(2):972-981. PMID: 26296158.
      Citations: 2     Fields:    Translation:HumansCells
    10. Liu J, Pham PT, Skripnikova EV, Zheng S, Lovings LJ, Wang Y, Goyal N, Bellow SM, Mensah LM, Chatters AJ, Bratton MR, Wiese TE, Zhao M, Wang G, Foroozesh M. A Ligand-Based Drug Design. Discovery of 4-Trifluoromethyl-7,8-pyranocoumarin as a Selective Inhibitor of Human Cytochrome P450 1A2. J Med Chem. 2015 Aug 27; 58(16):6481-93. PMID: 26222195.
      Citations: 1     Fields:    Translation:HumansCells
    11. Bratton MR, Martin EC, Elliott S, Rhodes LV, Collins-Burow BM, McLachlan JA, Wiese TE, Boue SM, Burow ME. Glyceollin, a novel regulator of mTOR/p70S6 in estrogen receptor positive breast cancer. J Steroid Biochem Mol Biol. 2015 Jun; 150:17-23. PMID: 25771071.
      Citations: 4     Fields:    Translation:HumansCells
    12. Chimezie C, Ewing AC, Quadri SS, Cole RB, Boué SM, Omari CF, Bratton M, Glotser E, Skripnikova E, Townley I, Stratford RE. Glyceollin transport, metabolism, and effects on p-glycoprotein function in Caco-2 cells. J Med Food. 2014 Apr; 17(4):462-71. PMID: 24476214.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    13. Sridhar J, Sfondouris ME, Bratton MR, Nguyen TL, Townley I, Klein Stevens CL, Jones FE. Identification of quinones as HER2 inhibitors for the treatment of trastuzumab resistant breast cancer. Bioorg Med Chem Lett. 2014 Jan 01; 24(1):126-31. PMID: 24355130.
      Citations: 2     Fields:    Translation:HumansCells
    14. Tilghman SL, Townley I, Zhong Q, Carriere PP, Zou J, Llopis SD, Preyan LC, Williams CC, Skripnikova E, Bratton MR, Zhang Q, Wang G. Proteomic signatures of acquired letrozole resistance in breast cancer: suppressed estrogen signaling and increased cell motility and invasiveness. Mol Cell Proteomics. 2013 Sep; 12(9):2440-55. PMID: 23704778.
      Citations: 26     Fields:    Translation:HumansCells
    15. Tilghman SL, Rhodes LV, Bratton MR, Carriere P, Preyan LC, Boue SM, Vasaitis TS, McLachlan JA, Burow ME. Phytoalexins, miRNAs and breast cancer: a review of phytochemical-mediated miRNA regulation in breast cancer. J Health Care Poor Underserved. 2013 Feb; 24(1 Suppl):36-46. PMID: 23395943.
      Citations: 5     Fields:    Translation:Humans
    16. Martin EC, Bratton MR, Zhu Y, Rhodes LV, Tilghman SL, Collins-Burow BM, Burow ME. Insulin-like growth factor-1 signaling regulates miRNA expression in MCF-7 breast cancer cell line. PLoS One. 2012; 7(11):e49067. PMID: 23226206.
      Citations: 10     Fields:    Translation:HumansCells
    17. Antoon JW, Bratton MR, Guillot LM, Wadsworth S, Salvo VA, Burow ME. Inhibition of p38-MAPK alters SRC coactivation and estrogen receptor phosphorylation. Cancer Biol Ther. 2012 Sep; 13(11):1026-33. PMID: 22825349.
      Citations: 3     Fields:    Translation:HumansCells
    18. Antoon JW, Bratton MR, Guillot LM, Wadsworth S, Salvo VA, Elliott S, McLachlan JA, Burow ME. Pharmacology and anti-tumor activity of RWJ67657, a novel inhibitor of p38 mitogen activated protein kinase. Am J Cancer Res. 2012; 2(4):446-58. PMID: 22860234.
    19. Bratton MR, Frigo DE, Segar HC, Nephew KP, McLachlan JA, Wiese TE, Burow ME. The organochlorine o,p'-DDT plays a role in coactivator-mediated MAPK crosstalk in MCF-7 breast cancer cells. Environ Health Perspect. 2012 Sep; 120(9):1291-6. PMID: 22609851.
      Citations: 6     Fields:    Translation:HumansCells
    20. Bratton MR, Antoon JW, Duong BN, Frigo DE, Tilghman S, Collins-Burow BM, Elliott S, Tang Y, Melnik LI, Lai L, Alam J, Beckman BS, Hill SM, Rowan BG, McLachlan JA, Burow ME. Gao potentiates estrogen receptor a activity via the ERK signaling pathway. J Endocrinol. 2012 Jul; 214(1):45-54. PMID: 22562654.
      Citations: 7     Fields:    Translation:HumansCells
    21. Zhou C, Zhong Q, Rhodes LV, Townley I, Bratton MR, Zhang Q, Martin EC, Elliott S, Collins-Burow BM, Burow ME, Wang G. Proteomic analysis of acquired tamoxifen resistance in MCF-7 cells reveals expression signatures associated with enhanced migration. Breast Cancer Res. 2012 Mar 14; 14(2):R45. PMID: 22417809.
      Citations: 39     Fields:    Translation:HumansCells
    22. Tilghman SL, Bratton MR, Segar HC, Martin EC, Rhodes LV, Li M, McLachlan JA, Wiese TE, Nephew KP, Burow ME. Endocrine disruptor regulation of microRNA expression in breast carcinoma cells. PLoS One. 2012; 7(3):e32754. PMID: 22403704.
      Citations: 38     Fields:    Translation:HumansCells
    23. McLachlan JA, Tilghman SL, Burow ME, Bratton MR. Environmental signaling and reproduction: a comparative biological and chemical perspective. Mol Cell Endocrinol. 2012 May 06; 354(1-2):60-2. PMID: 22178089.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    24. Rhodes LV, Tilghman SL, Boue SM, Wang S, Khalili H, Muir SE, Bratton MR, Zhang Q, Wang G, Burow ME, Collins-Burow BM. Glyceollins as novel targeted therapeutic for the treatment of triple-negative breast cancer. Oncol Lett. 2012 Jan; 3(1):163-171. PMID: 22740874.
    25. Rhodes LV, Bratton MR, Zhu Y, Tilghman SL, Muir SE, Salvo VA, Tate CR, Elliott S, Nephew KP, Collins-Burow BM, Burow ME. Effects of SDF-1-CXCR4 signaling on microRNA expression and tumorigenesis in estrogen receptor-alpha (ER-a)-positive breast cancer cells. Exp Cell Res. 2011 Nov 01; 317(18):2573-81. PMID: 21906588.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    26. Antoon JW, Meacham WD, Bratton MR, Slaughter EM, Rhodes LV, Ashe HB, Wiese TE, Burow ME, Beckman BS. Pharmacological inhibition of sphingosine kinase isoforms alters estrogen receptor signaling in human breast cancer. J Mol Endocrinol. 2011 Jun; 46(3):205-16. PMID: 21321095.
      Citations: 25     Fields:    Translation:HumansCells
    27. Rhodes LV, Short SP, Neel NF, Salvo VA, Zhu Y, Elliott S, Wei Y, Yu D, Sun M, Muir SE, Fonseca JP, Bratton MR, Segar C, Tilghman SL, Sobolik-Delmaire T, Horton LW, Zaja-Milatovic S, Collins-Burow BM, Wadsworth S, Beckman BS, Wood CE, Fuqua SA, Nephew KP, Dent P, Worthylake RA, Curiel TJ, Hung MC, Richmond A, Burow ME. Cytokine receptor CXCR4 mediates estrogen-independent tumorigenesis, metastasis, and resistance to endocrine therapy in human breast cancer. Cancer Res. 2011 Jan 15; 71(2):603-13. PMID: 21123450.
      Citations: 74     Fields:    Translation:HumansAnimalsCells
    28. Bratton MR, Duong BN, Elliott S, Weldon CB, Beckman BS, McLachlan JA, Burow ME. Regulation of ERalpha-mediated transcription of Bcl-2 by PI3K-AKT crosstalk: implications for breast cancer cell survival. Int J Oncol. 2010 Sep; 37(3):541-50. PMID: 20664923.
      Citations: 20     Fields:    Translation:HumansCells
    29. Bratton MR, Frigo DE, Vigh-Conrad KA, Fan D, Wadsworth S, McLachlan JA, Burow ME. Organochlorine-mediated potentiation of the general coactivator p300 through p38 mitogen-activated protein kinase. Carcinogenesis. 2009 Jan; 30(1):106-13. PMID: 18791200.
      Citations: 18     Fields:    Translation:HumansCells
    30. Duong BN, Elliott S, Frigo DE, Melnik LI, Vanhoy L, Tomchuck S, Lebeau HP, David O, Beckman BS, Alam J, Bratton MR, McLachlan JA, Burow ME. AKT regulation of estrogen receptor beta transcriptional activity in breast cancer. Cancer Res. 2006 Sep 01; 66(17):8373-81. PMID: 16951146.
      Citations: 16     Fields:    Translation:HumansCells
    31. Bratton MR, Gomez-Sanchez EP, Gomez-Sanchez CE, Subauste JS. The myosin binding protein is a novel mineralocorticoid receptor binding partner. Mol Cell Endocrinol. 2004 Mar 31; 217(1-2):221-7. PMID: 15134821.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    32. Bratton M, Mills D, Castleden CK, Hosler J, Meunier B. Disease-related mutations in cytochrome c oxidase studied in yeast and bacterial models. Eur J Biochem. 2003 Mar; 270(6):1222-30. PMID: 12631280.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    33. Bratton MR, Hiser L, Antholine WE, Hoganson C, Hosler JP. Identification of the structural subunits required for formation of the metal centers in subunit I of cytochrome c oxidase of Rhodobacter sphaeroides. Biochemistry. 2000 Oct 24; 39(42):12989-95. PMID: 11041864.
      Citations: 5     Fields:    Translation:Cells
    34. Bratton MR, Pressler MA, Hosler JP. Suicide inactivation of cytochrome c oxidase: catalytic turnover in the absence of subunit III alters the active site. Biochemistry. 1999 Dec 07; 38(49):16236-45. PMID: 10587446.
      Citations: 18     Fields:    Translation:Cells
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