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Madhusoodanan Mottamal

TitleDrug Discovery Core
Faculty RankStaff Researcher
InstitutionXavier University of Louisiana
AddressXavier University of Louisiana
1 Drexel Drive
New Orleans LA 70125
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    Other Positions
    TitleCore Scientist
    InstitutionXavier University of LA

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Al-Horani RA, Aliter KF, Kar S, Mottamal M. Sulfonated Nonsaccharide Heparin Mimetics Are Potent and Noncompetitive Inhibitors of Human Neutrophil Elastase. ACS Omega. 2021 May 18; 6(19):12699-12710. PMID: 34056422.
    2. Mottamal M, Kang B, Peng X, Wang G. From Pure Antagonists to Pure Degraders of the Estrogen Receptor: Evolving Strategies for the Same Target. ACS Omega. 2021 Apr 13; 6(14):9334-9343. PMID: 33869913.
    3. Kar S, Mottamal M, Al-Horani RA. Discovery of Benzyl Tetraphosphonate Derivative as Inhibitor of Human Factor Xia. ChemistryOpen. 2020 11; 9(11):1161-1172. PMID: 33204588.
    4. Guo S, Zhang C, Mottamal M, Hossain A, Liu J, Wang G. GLL398, an oral selective estrogen receptor degrader (SERD), blocks tumor growth in xenograft breast cancer models. Breast Cancer Res Treat. 2020 Apr; 180(2):359-368. PMID: 32030569.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    5. Zhang JH, Mottamal M, Jin HS, Guo S, Gu Y, Wang G, Zhao LM. Design, synthesis and evaluation of belinostat analogs as histone deacetylase inhibitors. Future Med Chem. 2019 11; 11(21):2765-2778. PMID: 31702394.
      Citations:    Fields:    
    6. Al-Horani RA, Clemons D, Mottamal M. The In Vitro Effects of Pentamidine Isethionate on Coagulation and Fibrinolysis. Molecules. 2019 Jun 06; 24(11). PMID: 31174390.
      Citations: 3     Fields:    Translation:Humans
    7. Guo S, Zhang C, Bratton M, Mottamal M, Liu J, Ma P, Zheng S, Zhong Q, Yang L, Wiese TE, Wu Y, Ellis MJ, Matossian M, Burow ME, Miele L, Houtman R, Wang G. ZB716, a steroidal selective estrogen receptor degrader (SERD), is orally efficacious in blocking tumor growth in mouse xenograft models. Oncotarget. 2018 Jan 23; 9(6):6924-6937. PMID: 29467940.
      Citations: 8     Fields:    
    8. Jennings S, Chenevert M, Liu L, Mottamal M, Wojcik EJ, Huckaba TM. Characterization of kinesin switch I mutations that cause hereditary spastic paraplegia. PLoS One. 2017; 12(7):e0180353. PMID: 28678816.
      Citations: 9     Fields:    Translation:HumansCells
    9. Vanden Eynde JJ, Mayence A, Mottamal M, Bacchi CJ, Yarlett N, Kaiser M, Brun R, Huang TL. Alkanediamide-Linked Bisbenzamidines Are Promising Antiparasitic Agents. Pharmaceuticals (Basel). 2016 Apr 19; 9(2). PMID: 27104545.
    10. Jung SK, Ha SJ, Jung CH, Kim YT, Lee HK, Kim MO, Lee MH, Mottamal M, Bode AM, Lee KW, Dong Z. Naringenin targets ERK2 and suppresses UVB-induced photoaging. J Cell Mol Med. 2016 May; 20(5):909-19. PMID: 26861188.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    11. Chu X, Battle CH, Zhang N, Aryal GH, Mottamal M, Jayawickramarajah J. Bile Acid Conjugated DNA Chimera that Conditionally Inhibits Carbonic Anhydrase-II in the Presence of MicroRNA-21. Bioconjug Chem. 2015 Aug 19; 26(8):1606-12. PMID: 26191606.
      Citations: 1     Fields:    Translation:HumansCells
    12. Berger ML, Maciejewska D, Vanden Eynde JJ, Mottamal M, Zabinski J, Kazmierczak P, Rezler M, Jarak I, Piantanida I, Karminski-Zamola G, Mayence A, Rebernik P, Kumar A, Ismail MA, Boykin DW, Huang TL. Pentamidine analogs as inhibitors of [(3)H]MK-801 and [(3)H]ifenprodil binding to rat brain NMDA receptors. Bioorg Med Chem. 2015 Aug 01; 23(15):4489-4500. PMID: 26117647.
      Citations: 1     Fields:    Translation:AnimalsCells
    13. Mottamal M, Zheng S, Huang TL, Wang G. Histone deacetylase inhibitors in clinical studies as templates for new anticancer agents. Molecules. 2015 Mar 02; 20(3):3898-941. PMID: 25738536.
      Citations: 185     Fields:    Translation:HumansAnimals
    14. Li XL, Sluijter M, Doorduijn EM, Kale SP, McFerrin H, Liu YY, Li Y, Mottamal M, Yao X, Du F, Gu B, Hoang K, Nguyen YH, Taylor N, Stephens CR, van Hall T, Zhang QJ. Limited density of an antigen presented by RMA-S cells requires B7-1/CD28 signaling to enhance T-cell immunity at the effector phase. PLoS One. 2014; 9(11):e108192. PMID: 25383875.
      Citations: 1     Fields:    Translation:AnimalsCells
    15. Zheng S, Zhong Q, Xi Y, Mottamal M, Zhang Q, Schroeder RL, Sridhar J, He L, McFerrin H, Wang G. Modification and biological evaluation of thiazole derivatives as novel inhibitors of metastatic cancer cell migration and invasion. J Med Chem. 2014 Aug 14; 57(15):6653-67. PMID: 25007006.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    16. Zheng S, Zhong Q, Mottamal M, Zhang Q, Zhang C, Lemelle E, McFerrin H, Wang G. Design, synthesis, and biological evaluation of novel pyridine-bridged analogues of combretastatin-A4 as anticancer agents. J Med Chem. 2014 Apr 24; 57(8):3369-81. PMID: 24669888.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    17. Song NR, Lee E, Byun S, Kim JE, Mottamal M, Park JH, Lim SS, Bode AM, Lee HJ, Lee KW, Dong Z. Isoangustone A, a novel licorice compound, inhibits cell proliferation by targeting PI3K, MKK4, and MKK7 in human melanoma. Cancer Prev Res (Phila). 2013 Dec; 6(12):1293-303. PMID: 24104352.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    18. Zheng S, Zhong Q, Jiang Q, Mottamal M, Zhang Q, Zhu N, Burow ME, Worthylake RA, Wang G. Discovery of a Series of Thiazole Derivatives as Novel Inhibitors of Metastatic Cancer Cell Migration and Invasion. ACS Med Chem Lett. 2013 Feb 14; 4(2):191-196. PMID: 23526571.
    19. Li J, Mottamal M, Li H, Liu K, Zhu F, Cho YY, Sosa CP, Zhou K, Bowden GT, Bode AM, Dong Z. Quercetin-3-methyl ether suppresses proliferation of mouse epidermal JB6 P+ cells by targeting ERKs. Carcinogenesis. 2012 Feb; 33(2):459-65. PMID: 22139441.
      Citations: 7     Fields:    Translation:AnimalsCells
    20. Li J, Malakhova M, Mottamal M, Reddy K, Kurinov I, Carper A, Langfald A, Oi N, Kim MO, Zhu F, Sosa CP, Zhou K, Bode AM, Dong Z. Norathyriol suppresses skin cancers induced by solar ultraviolet radiation by targeting ERK kinases. Cancer Res. 2012 Jan 01; 72(1):260-70. PMID: 22084399.
      Citations: 18     Fields:    Translation:Animals
    21. Kim JE, Lee DE, Lee KW, Son JE, Seo SK, Li J, Jung SK, Heo YS, Mottamal M, Bode AM, Dong Z, Lee HJ. Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3-K. Cancer Prev Res (Phila). 2011 Apr; 4(4):582-91. PMID: 21330379.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    22. Wang Q, Wei Y, Mottamal M, Roberts MF, Krilov G. Understanding the stereospecific interactions of 3-deoxyphosphatidylinositol derivatives with the PTEN phosphatase domain. J Mol Graph Model. 2010 Aug 24; 29(1):102-14. PMID: 20538496.
      Citations: 4     Fields:    Translation:Cells
    23. Mottamal M, Shen S, Guembe C, Krilov G. Solvation of transmembrane proteins by isotropic membrane mimetics: a molecular dynamics study. J Phys Chem B. 2007 Sep 27; 111(38):11285-96. PMID: 17784746.
      Citations: 1     Fields:    Translation:Cells
    24. Mottamal M, Lazaridis T. Voltage-dependent energetics of alamethicin monomers in the membrane. Biophys Chem. 2006 Jun 20; 122(1):50-7. PMID: 16542770.
      Citations: 20     Fields:    Translation:Cells
    25. Mottamal M, Zhang J, Lazaridis T. Energetics of the native and non-native states of the glycophorin transmembrane helix dimer. Proteins. 2006 Mar 01; 62(4):996-1009. PMID: 16395713.
      Citations: 12     Fields:    Translation:Cells
    26. Mottamal M, Lazaridis T. The contribution of C alpha-H...O hydrogen bonds to membrane protein stability depends on the position of the amide. Biochemistry. 2005 Feb 08; 44(5):1607-13. PMID: 15683244.
      Citations: 10     Fields:    Translation:Cells
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