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Jacqueline Flores-Otero

Faculty RankAssistant Professor
InstitutionUniversity of Puerto Rico
DepartmentDeanship of Academic Affairs
AddressInstitute of Neurobiology
201 Blvd del Valle, Calle Norzagaray
San Juan PR 901
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    Collapse Overview 
    Collapse overview
    Interests: Our goal is to elucidate the role of adhesion G protein-coupled receptors (GPCRs) in regulating retinoblastoma (Rb) tumor development and progression with a focus on cellular migration. By using a combination of cellular and molecular approaches, in tandem with Total Internal Reflection Fluorescence (TIRF) microscopy, we will define the kinetic properties of these orphan receptors, and furthermore determine how alterations in the kinetics and signaling of adhesion proteins regulate Rb cell motility.

    Present Funding: NIH RCMI; Puerto Rico Science & Technology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Guihurt Santiago J, Burgos-Tirado N, Lafontaine DD, Mendoza Sierra JC, Camacho RH, Vecchini Rodríguez CM, Morales-Tirado V, Flores-Otero J. Adhesion G protein-coupled receptor, ELTD1, is a potential therapeutic target for retinoblastoma migration and invasion. BMC Cancer. 2021 Jan 11; 21(1):53. PMID: 33430814.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    2. Vecchini Rodríguez CM, Escalona Meléndez Y, Flores-Otero J. Cannabinoid Receptors and Ligands: Lessons from CNS Disorders and the Quest for Novel Treatment Venues. Adv Exp Med Biol. 2021; 1297:43-64. PMID: 33537936.
      Citations:    Fields:    Translation:Humans
    3. Goldsmith ZK, Coppess W, Irvine AS, Yuan K, Barsh SR, Ritter MK, McEwen MW, Flores-Otero J, Garcia-Vargas A, Martinez-Ferrer M, Brennan RC, Morales-Tirado VM, Wilson MW. Targeting the Platelet-Derived Growth Factor-beta Stimulatory Circuitry to Control Retinoblastoma Seeds. Invest Ophthalmol Vis Sci. 2018 09 04; 59(11):4486-4495. PMID: 30193324.
      Citations: 3     Fields:    Translation:HumansCells
    4. González-Espada W, Díaz-Muñoz G, Feliú-Mójer M, Flores-Otero J, Fortis-Santiago Y, Guerrero-Medina G, López-Casillas M, Colón-Ramos DA, Fernández-Repollet E. Assessing a Science Graduate School Recruitment Symposium. Cuad Investig Educ. 2015 Dec; 30:55-70. PMID: 26770074.
    5. Roman-Vendrell C, Chevalier M, Acevedo-Canabal AM, Delgado-Peraza F, Flores-Otero J, Yudowski GA. Imaging of kiss-and-run exocytosis of surface receptors in neuronal cultures. Front Cell Neurosci. 2014; 8:363. PMID: 25404895.
    6. Flores-Otero J, Ahn KH, Delgado-Peraza F, Mackie K, Kendall DA, Yudowski GA. Ligand-specific endocytic dwell times control functional selectivity of the cannabinoid receptor 1. Nat Commun. 2014 Aug 01; 5:4589. PMID: 25081814.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    7. Guerrero-Medina G, Feliú-Mójer M, González-Espada W, Díaz-Muñoz G, López M, Díaz-Muñoz SL, Fortis-Santiago Y, Flores-Otero J, Craig D, Colón-Ramos DA. Supporting diversity in science through social networking. PLoS Biol. 2013 Dec; 11(12):e1001740. PMID: 24391467.
      Citations: 3     Fields:    Translation:Humans
    8. Zhang J, Benavente CA, McEvoy J, Flores-Otero J, Ding L, Chen X, Ulyanov A, Wu G, Wilson M, Wang J, Brennan R, Rusch M, Manning AL, Ma J, Easton J, Shurtleff S, Mullighan C, Pounds S, Mukatira S, Gupta P, Neale G, Zhao D, Lu C, Fulton RS, Fulton LL, Hong X, Dooling DJ, Ochoa K, Naeve C, Dyson NJ, Mardis ER, Bahrami A, Ellison D, Wilson RK, Downing JR, Dyer MA. A novel retinoblastoma therapy from genomic and epigenetic analyses. Nature. 2012 Jan 11; 481(7381):329-34. PMID: 22237022.
      Citations: 223     Fields:    Translation:HumansAnimalsCells
    9. McEvoy J, Flores-Otero J, Zhang J, Nemeth K, Brennan R, Bradley C, Krafcik F, Rodriguez-Galindo C, Wilson M, Xiong S, Lozano G, Sage J, Fu L, Louhibi L, Trimarchi J, Pani A, Smeyne R, Johnson D, Dyer MA. Coexpression of normally incompatible developmental pathways in retinoblastoma genesis. Cancer Cell. 2011 Aug 16; 20(2):260-75. PMID: 21840489.
      Citations: 68     Fields:    Translation:HumansAnimals
    10. Flores-Otero J, Davis RL. Synaptic proteins are tonotopically graded in postnatal and adult type I and type II spiral ganglion neurons. J Comp Neurol. 2011 Jun 01; 519(8):1455-75. PMID: 21452215.
      Citations: 25     Fields:    Translation:AnimalsCells
    11. Brennan RC, Federico S, Bradley C, Zhang J, Flores-Otero J, Wilson M, Stewart C, Zhu F, Guy K, Dyer MA. Targeting the p53 pathway in retinoblastoma with subconjunctival Nutlin-3a. Cancer Res. 2011 Jun 15; 71(12):4205-13. PMID: 21515735.
      Citations: 31     Fields:    Translation:HumansAnimals
    12. Flores-Otero J, Xue HZ, Davis RL. Reciprocal regulation of presynaptic and postsynaptic proteins in bipolar spiral ganglion neurons by neurotrophins. J Neurosci. 2007 Dec 19; 27(51):14023-34. PMID: 18094241.
      Citations: 41     Fields:    Translation:AnimalsCells
    13. Reid MA, Flores-Otero J, Davis RL. Firing patterns of type II spiral ganglion neurons in vitro. J Neurosci. 2004 Jan 21; 24(3):733-42. PMID: 14736859.
      Citations: 35     Fields:    Translation:AnimalsCells
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