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José F. Rodríguez-Orengo

InstitutionUniversity of Puerto Rico
AddressUPR-Medical Sciences Campus
School of Medicine
P.O. Box 365067
San Juan PR 00936-5067
Phone(787) 758-2525 ext. 1349
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    The research that we are conducting is related to three main areas. The first area is the understanding of biochemical/pharmacology processes of antiretroviral and anticancer drugs in the Puerto Rican population. These studies include the plasmatic and intracellular pharmacokinetics of such agents in the pediatric, adolescent, and adult populations. Furthermore, we are interested in the enzymatic pathways that are responsible for the activation of these drugs. The second area is related with biomarkers of disease using endogenous antioxidant agents and related compounds. Glutathione is being studied as a marker for disease progression in HIV patients. In addition, we are studying homocysteine levels in patients with cardiac problems, to understand the role of this compound and its enzymes at different stages of the disease. Molecular biology will be used to probe the genetic differences of important enzymes responsible for the production and excretion of these compounds. The third area is within the Center for Environmental Research and Toxicology, where a multidisciplinary approach is used to answer relevant environmental problems that are affecting the Puerto Rican population.

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Maldonado MDM, Rosado-González G, Bloom J, Duconge J, Ruiz-Calderón JF, Hernández-O'Farrill E, Vlaar C, Rodríguez-Orengo JF, Dharmawardhane S. Pharmacokinetics of the Rac/Cdc42 Inhibitor MBQ-167 in Mice by Supercritical Fluid Chromatography-Tandem Mass Spectrometry. ACS Omega. 2019 Nov 05; 4(19):17981-17989. PMID: 31720502.
    2. Mattei J, Tamez M, Bigornia SJ, Noel SE, Xiao RS, Ríos-Bedoya CF, Rodríguez-Orengo JF, Tucker KL. Dietary Intake and Its Determinants Among Adults Living in the Metropolitan Area of Puerto Rico. Nutrients. 2019 Jul 14; 11(7). PMID: 31337152.
      Citations:    Fields:    Translation:Humans
    3. Tamez M, Ríos-Bedoya CF, Rodríguez-Orengo JF, Tucker KL, Mattei J. Sociodemographic and Lifestyle Factors, and Health Conditions of Dominican Adults Living in Puerto Rico. J Immigr Minor Health. 2018 Oct; 20(5):1085-1093. PMID: 28808807.
      Citations:    Fields:    Translation:Humans
    4. Preston AM, Rodríguez-Orengo J, González-Sepúlveda L, Ayala-Peña S, Maldonado-Maldonado E. Effect of Housing Type on 25 OH Vitamin D in Serum of Rhesus Monkeys. P R Health Sci J. 2018 06; 37(2):124-127. PMID: 29905924.
      Citations:    Fields:    Translation:Animals
    5. Mattei J, Tamez M, Ríos-Bedoya CF, Xiao RS, Tucker KL, Rodríguez-Orengo JF. Health conditions and lifestyle risk factors of adults living in Puerto Rico: a cross-sectional study. BMC Public Health. 2018 04 12; 18(1):491. PMID: 29650018.
      Citations: 2     Fields:    Translation:Humans
    6. Mattei J, Rodríguez-Orengo JF, Tamez M, Corujo F, Claudio A, Villanueva H, Campos H, Willett WC, Tucker KL, Ríos-Bedoya CF. Challenges and opportunities in establishing a collaborative multisite observational study of chronic diseases and lifestyle factors among adults in Puerto Rico. BMC Public Health. 2017 01 31; 17(1):136. PMID: 28143452.
      Citations: 2     Fields:    Translation:Humans
    7. Castillo-Pichardo L, Dharmawardhane S, Rodríguez-Orengo JF. Rapid quantification of resveratrol in mouse plasma by ultra high pressure liquid chromatography (UPLC) coupled to tandem mass spectrometry. P R Health Sci J. 2014 Dec; 33(4):151-6. PMID: 25563031.
      Citations:    Fields:    Translation:AnimalsCells
    8. Mosquera L, Colón JM, Santiago JM, Torrado AI, Meléndez M, Segarra AC, Rodríguez-Orengo JF, Miranda JD. Tamoxifen and estradiol improved locomotor function and increased spared tissue in rats after spinal cord injury: their antioxidant effect and role of estrogen receptor alpha. Brain Res. 2014 May 02; 1561:11-22. PMID: 24637260.
      Citations: 21     Fields:    Translation:AnimalsCells
    9. Rodríguez-Torres M, Burguera J, Hallman D, Rodríguez-Orengo J, Echeandia M.  Hepatitis C viral kinetics in Latino patients: a comparison to African American and Caucasian patients. Ann Hepatol. 2012 Jul-Aug; 11(4):450-63. PMID: 22700626.
      Citations:    Fields:    Translation:HumansCells
    10. Albizu-García CE, Hernández-Viver A, Feal J, Rodríguez-Orengo JF. Characteristics of inmates witnessing overdose events in prison: implications for prevention in the correctional setting. Harm Reduct J. 2009 Jul 09; 6:15. PMID: 19589157.
      Citations: 6     Fields:    
    11. Vega-Rodríguez J, Franke-Fayard B, Dinglasan RR, Janse CJ, Pastrana-Mena R, Waters AP, Coppens I, Rodríguez-Orengo JF, Srinivasan P, Jacobs-Lorena M, Serrano AE. The glutathione biosynthetic pathway of Plasmodium is essential for mosquito transmission. PLoS Pathog. 2009 Feb; 5(2):e1000302. PMID: 19229315.
      Citations: 28     Fields:    Translation:AnimalsCells
    12. Ramírez-Marrero FA, Rivera-Brown AM, Nazario CM, Rodríguez-Orengo JF, Smit E, Smith BA. Self-reported physical activity in Hispanic adults living with HIV: comparison with accelerometer and pedometer. J Assoc Nurses AIDS Care. 2008 Jul-Aug; 19(4):283-94. PMID: 18598903.
      Citations: 8     Fields:    Translation:Humans
    13. Laspiur JP, Anderson ER, Ciborowski P, Wojna V, Rozek W, Duan F, Mayo R, Rodríguez E, Plaud-Valentín M, Rodríguez-Orengo J, Gendelman HE, Meléndez LM. CSF proteomic fingerprints for HIV-associated cognitive impairment. J Neuroimmunol. 2007 Dec; 192(1-2):157-70. PMID: 17950469.
      Citations: 35     Fields:    Translation:Humans
    14. Rodríguez-Torres M, Rodríguez-Orengo JF, Ríos-Bedoya CF, Fernández-Carbia A, Marxuach-Cuétara AM, López-Torres A, Jiménez-Rivera J. Effect of hepatitis C virus treatment in fibrosis progression rate (FPR) and time to cirrhosis (TTC) in patients co-infected with human immunodeficiency virus: a paired liver biopsy study. J Hepatol. 2007 Apr; 46(4):613-9. PMID: 17316873.
      Citations: 3     Fields:    Translation:Humans
    15. Rodríguez-Torres M, Rodríguez-Orengo JF, Ríos-Bedoya CF, Fernández-Carbia A, González-Lassalle E, Salgado-Mercado R, Marxuach-Cuétara AM. Efficacy and safety of peg-IFN alfa-2a with ribavirin for the treatment of HCV/HIV coinfected patients who failed previous IFN based therapy. J Clin Virol. 2007 Jan; 38(1):32-8. PMID: 17064957.
      Citations: 4     Fields:    Translation:HumansCellsCTClinical Trials
    16. Rodríguez-Torres M, Ríos-Bedoya CF, Rodríguez-Orengo J, Fernández-Carbia A, Marxuach-Cuétara AM, López-Torres A, Salgado-Mercado R, Bräu N. Progression to cirrhosis in Latinos with chronic hepatitis C: differences in Puerto Ricans with and without human immunodeficiency virus coinfection and along gender. J Clin Gastroenterol. 2006 Apr; 40(4):358-66. PMID: 16633110.
      Citations: 10     Fields:    Translation:Humans
    17. Bräu N, Salvatore M, Ríos-Bedoya CF, Fernández-Carbia A, Paronetto F, Rodríguez-Orengo JF, Rodríguez-Torres M. Slower fibrosis progression in HIV/HCV-coinfected patients with successful HIV suppression using antiretroviral therapy. J Hepatol. 2006 Jan; 44(1):47-55. PMID: 16182404.
      Citations: 110     Fields:    Translation:HumansCells
    18. Rodríguez-Torres M, Salgado-Mercado R, Ríos-Bedoya CF, Aponte-Rivera E, Marxuach-Cuétara AM, Rodríguez-Orengo JF, Fernández-Carbia A. High eradication rates of Helicobacter pylori infection with first- and second-line combination of esomeprazole, tetracycline, and metronidazole in patients allergic to penicillin. Dig Dis Sci. 2005 Apr; 50(4):634-9. PMID: 15844694.
      Citations: 5     Fields:    Translation:HumansCellsCTClinical Trials
    19. Santana JL, Rodríguez-Medina JR, Rodríguez-Orengo JF. Clinical challenges and controversies in the management of HIV/ HCV-coinfected individuals. P R Health Sci J. 2004 Jun; 23(2 Suppl):35-40. PMID: 16929585.
      Citations: 2     Fields:    Translation:Humans
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