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Karen G. Martinez

Faculty RankAssistant Professor
InstitutionUniversity of Puerto Rico
AddressUPR- Medical Sciences Campus
School of Medicine
P.O. Box 365067
San Juan PR 936
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    Dr. Karen G. Martínez received her medical degree from the University of Puerto Rico in 2001 and completed her residency and fellowship training in Child and Adolescent Psychiatry at the same institution in 2006. She is also completed a Post-doctoral Master’s in Clinical Research. During her two years as a post-doctoral research scholar, she completed her research work on the role of maternal depression in pediatric asthma under the mentorship of Dr. Glorisa Canino. This work was published in the Journal of Asthma in 2008. On 2009, she was given additional funding for research and moved her line of research into the area of fear learning and anxiety disorder under the mentorship of Dr. Gregory Quirk. Her work at this time consists of trying to understand the role of extinction in anxiety disorders. Specifically, she is looking for predictors of response to therapies that rely on extinction processes and the particularities of anxiety treatment in Puerto Ricans. She has published three papers on this line of work and has presented it on multiple local, national and international conferences. With this work, she was accepted in the NIH Loan Repayment Program and she was also awarded the Anxiety Disorders of America Career Development Award and the American College of Neuropsychopharmacology Minority Faculty Award. She was also the Director of the Research Program at the University Of Puerto Rico Department Of Psychiatry until July, 2011. She is currently the director of the University of Puerto Rico Center for the Study and Treatment of Fear and Anxiety where she performs her research projects as well as directs an evidence-based clinic for anxiety disorders.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kacenauskaite L, Gabrielaitis D, Bærentsen N, Martinez KL, Vosch T, Laursen BW. Intrinsic anti-Stokes emission in living HeLa cells. PLoS One. 2020; 15(3):e0230441. PMID: 32176729.
      Citations:    Fields:    Translation:HumansCells
    2. Erlendsson S, Thorsen TS, Vauquelin G, Ammendrup-Johnsen I, Wirth V, Martinez KL, Teilum K, Gether U, Madsen KL. Mechanisms of PDZ domain scaffold assembly illuminated by use of supported cell membrane sheets. Elife. 2019 01 03; 8. PMID: 30605082.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    3. Buch-Månson N, Spangenberg A, Gomez LPC, Malval JP, Soppera O, Martinez KL. Rapid Prototyping of Polymeric Nanopillars by 3D Direct Laser Writing for Controlling Cell Behavior. Sci Rep. 2017 08 23; 7(1):9247. PMID: 28835653.
      Citations: 3     Fields:    Translation:AnimalsCells
    4. Frederiksen R, Tutuncuoglu G, Matteini F, Martinez KL, Fontcuberta I Morral A, Alarcon-Llado E. Visual Understanding of Light Absorption and Waveguiding in Standing Nanowires with 3D Fluorescence Confocal Microscopy. ACS Photonics. 2017 Sep 20; 4(9):2235-2241. PMID: 28966933.
    5. Rosholm KR, Leijnse N, Mantsiou A, Tkach V, Pedersen SL, Wirth VF, Oddershede LB, Jensen KJ, Martinez KL, Hatzakis NS, Bendix PM, Callan-Jones A, Stamou D. Membrane curvature regulates ligand-specific membrane sorting of GPCRs in living cells. Nat Chem Biol. 2017 Jul; 13(7):724-729. PMID: 28481347.
      Citations: 11     Fields:    Translation:AnimalsCells
    6. Buch-Månson N, Kang DH, Kim D, Lee KE, Yoon MH, Martinez KL. Mapping cell behavior across a wide range of vertical silicon nanocolumn densities. Nanoscale. 2017 May 04; 9(17):5517-5527. PMID: 28401963.
      Citations: 3     Fields:    
    7. Bavishi K, Laursen T, Martinez KL, Møller BL, Della Pia EA. Application of nanodisc technology for direct electrochemical investigation of plant cytochrome P450s and their NADPH P450 oxidoreductase. Sci Rep. 2016 07 08; 6:29459. PMID: 27386958.
      Citations: 3     Fields:    Translation:AnimalsCells
    8. Hansen RW, Wang X, Golab A, Bornert O, Oswald C, Wagner R, Martinez KL. Functional Stability of the Human Kappa Opioid Receptor Reconstituted in Nanodiscs Revealed by a Time-Resolved Scintillation Proximity Assay. PLoS One. 2016; 11(4):e0150658. PMID: 27035823.
      Citations:    Fields:    Translation:HumansAnimalsCells
    9. Vutti S, Schoffelen S, Bolinsson J, Buch-Månson N, Bovet N, Nygård J, Martinez KL, Meldal M. Click Chemistry Mediated Functionalization of Vertical Nanowires for Biological Applications. Chemistry. 2016 Jan 11; 22(2):496-500. PMID: 26601641.
      Citations: 3     Fields:    Translation:Cells
    10. Giusti F, Kessler P, Hansen RW, Della Pia EA, Le Bon C, Mourier G, Popot JL, Martinez KL, Zoonens M. Synthesis of a Polyhistidine-bearing Amphipol and its Use for Immobilizing Membrane Proteins. Biomacromolecules. 2015 Dec 14; 16(12):3751-61. PMID: 26492302.
      Citations: 3     Fields:    
    11. Bender J, Engeholm M, Ederer MS, Breu J, Møller TC, Michalakis S, Rasko T, Wanker EE, Biel M, Martinez KL, Wurst W, Deussing JM. Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif. PLoS One. 2015; 10(9):e0136768. PMID: 26352593.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    12. Andersen TB, López CQ, Manczak T, Martinez K, Simonsen HT. Thapsigargin--from Thapsia L. to mipsagargin. Molecules. 2015 Apr 08; 20(4):6113-27. PMID: 25856061.
      Citations: 13     Fields:    Translation:AnimalsCells
    13. Della Pia EA, Martinez KL. Single domain antibodies as a powerful tool for high quality surface plasmon resonance studies. PLoS One. 2015; 10(3):e0124303. PMID: 25822527.
      Citations: 3     Fields:    Translation:Cells
    14. Vutti S, Buch-Månson N, Schoffelen S, Bovet N, Martinez KL, Meldal M. Covalent and stable CuAAC modification of silicon surfaces for control of cell adhesion. Chembiochem. 2015 Mar 23; 16(5):782-91. PMID: 25737226.
      Citations: 3     Fields:    Translation:HumansCells
    15. Frederiksen RS, Alarcon-Llado E, Madsen MH, Rostgaard KR, Krogstrup P, Vosch T, Nygård J, Fontcuberta I Morral A, Martinez KL. Modulation of fluorescence signals from biomolecules along nanowires due to interaction of light with oriented nanostructures. . 2015 Jan 14; 15(1):176-81. PMID: 25426704.
    16. Gonzalez P, Martinez KG. The role of stress and fear in the development of mental disorders. Psychiatr Clin North Am. 2014 Dec; 37(4):535-46. PMID: 25455064.
      Citations: 8     Fields:    Translation:Humans
    17. Bonde S, Buch-Månson N, Rostgaard KR, Andersen TK, Berthing T, Martinez KL. Exploring arrays of vertical one-dimensional nanostructures for cellular investigations. Nanotechnology. 2014 Sep 12; 25(36):362001. PMID: 25130133.
      Citations: 7     Fields:    Translation:HumansAnimals
    18. Yahirun JJ, Hamplová D. CHILDREN'S UNION STATUS AND CONTACT WITH MOTHERS: A CROSS-NATIONAL STUDY. Demogr Res. 2014 Jan-Jun; 30:1413-1444. PMID: 24062006.
      Citations: 8     Fields:    Translation:Animals
    19. Yahirun JJ, Hamplová D. CHILDREN'S UNION STATUS AND CONTACT WITH MOTHERS: A CROSS-NATIONAL STUDY. Demogr Res. 2014 Jan-Jun; 30:1413-1444. PMID: 21114410.
      Citations: 5     Fields:    Translation:Humans
    20. Le Bon C, Della Pia EA, Giusti F, Lloret N, Zoonens M, Martinez KL, Popot JL. Synthesis of an oligonucleotide-derivatized amphipol and its use to trap and immobilize membrane proteins. Nucleic Acids Res. 2014 Jun; 42(10):e83. PMID: 24744236.
      Citations: 7     Fields:    Translation:Cells
    21. Della Pia EA, Hansen RW, Zoonens M, Martinez KL. Functionalized amphipols: a versatile toolbox suitable for applications of membrane proteins in synthetic biology. J Membr Biol. 2014 Oct; 247(9-10):815-26. PMID: 24728227.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    22. Della Pia EA, Holm JV, Lloret N, Le Bon C, Popot JL, Zoonens M, Nygård J, Martinez KL. A step closer to membrane protein multiplexed nanoarrays using biotin-doped polypyrrole. ACS Nano. 2014 Feb 25; 8(2):1844-53. PMID: 24476392.
      Citations: 8     Fields:    
    23. Bonde S, Berthing T, Madsen MH, Andersen TK, Buch-Månson N, Guo L, Li X, Badique F, Anselme K, Nygård J, Martinez KL. Tuning InAs nanowire density for HEK293 cell viability, adhesion, and morphology: perspectives for nanowire-based biosensors. ACS Appl Mater Interfaces. 2013 Nov 13; 5(21):10510-9. PMID: 24074264.
      Citations: 12     Fields:    Translation:HumansCells
    24. Justesen BH, Hansen RW, Martens HJ, Theorin L, Palmgren MG, Martinez KL, Pomorski TG, Fuglsang AT. Active plasma membrane P-type H+-ATPase reconstituted into nanodiscs is a monomer. J Biol Chem. 2013 Sep 13; 288(37):26419-29. PMID: 23836891.
      Citations: 9     Fields:    Translation:AnimalsCells
    25. Møller TC, Wirth VF, Roberts NI, Bender J, Bach A, Jacky BP, Strømgaard K, Deussing JM, Schwartz TW, Martinez KL. PDZ domain-mediated interactions of G protein-coupled receptors with postsynaptic density protein 95: quantitative characterization of interactions. PLoS One. 2013; 8(5):e63352. PMID: 23691031.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    26. Bornert O, Møller TC, Boeuf J, Candusso MP, Wagner R, Martinez KL, Simonin F. Identification of a novel protein-protein interaction motif mediating interaction of GPCR-associated sorting proteins with G protein-coupled receptors. PLoS One. 2013; 8(2):e56336. PMID: 23441177.
      Citations: 10     Fields:    Translation:HumansCells
    27. Lloret N, Frederiksen RS, Møller TC, Rieben NI, Upadhyay S, De Vico L, Jensen JH, Nygård J, Martinez KL. Effects of buffer composition and dilution on nanowire field-effect biosensors. Nanotechnology. 2013 Jan 25; 24(3):035501. PMID: 23263553.
      Citations: 5     Fields:    Translation:Cells
    28. Mumm F, Beckwith KM, Bonde S, Martinez KL, Sikorski P. A transparent nanowire-based cell impalement device suitable for detailed cell-nanowire interaction studies. Small. 2013 Jan 28; 9(2):263-72. PMID: 23034997.
      Citations: 10     Fields:    
    29. Berthing T, Bonde S, Rostgaard KR, Madsen MH, Sørensen CB, Nygård J, Martinez KL. Cell membrane conformation at vertical nanowire array interface revealed by fluorescence imaging. Nanotechnology. 2012 Oct 19; 23(41):415102. PMID: 23010859.
      Citations: 17     Fields:    Translation:HumansCells
    30. Martínez KG, Castro-Couch M, Franco-Chaves JA, Ojeda-Arce B, Segura G, Milad MR, Quirk GJ. Correlations between psychological tests and physiological responses during fear conditioning and renewal. Biol Mood Anxiety Disord. 2012 Sep 17; 2:16. PMID: 22985550.
    31. De Vico L, Iversen L, Sørensen MH, Brandbyge M, Nygård J, Martinez KL, Jensen JH. Predicting and rationalizing the effect of surface charge distribution and orientation on nano-wire based FET bio-sensors. Nanoscale. 2011 Sep 01; 3(9):3635-40. PMID: 21811738.
      Citations: 4     Fields:    Translation:Cells
    32. Berthing T, Bonde S, Sørensen CB, Utko P, Nygård J, Martinez KL. Intact mammalian cell function on semiconductor nanowire arrays: new perspectives for cell-based biosensing. Small. 2011 Mar 07; 7(5):640-7. PMID: 21290597.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    33. De Vico L, Sørensen MH, Iversen L, Rogers DM, Sørensen BS, Brandbyge M, Nygård J, Martinez KL, Jensen JH. Quantifying signal changes in nano-wire based biosensors. Nanoscale. 2011 Feb; 3(2):706-17. PMID: 21173975.
      Citations: 3     Fields:    Translation:Cells
    34. Liu YC, Rieben N, Iversen L, Sørensen BS, Park J, Nygård J, Martinez KL. Specific and reversible immobilization of histidine-tagged proteins on functionalized silicon nanowires. Nanotechnology. 2010 Jun 18; 21(24):245105. PMID: 20498527.
      Citations: 10     Fields:    
    35. Iversen L, Younes-Metzler O, Martinez KL, Stamou D. Chemically specific laser-induced patterning of alkanethiol SAMs: characterization by SEM and AFM. Langmuir. 2009 Nov 03; 25(21):12819-24. PMID: 19624108.
      Citations: 2     Fields:    
    36. Martinez K, Estevez MC, Wu Y, Phillips JA, Medley CD, Tan W. Locked nucleic acid based beacons for surface interaction studies and biosensor development. Anal Chem. 2009 May 01; 81(9):3448-54. PMID: 19351140.
      Citations: 6     Fields:    Translation:AnimalsCells
    37. Martínez KG, Quirk GJ. Extending fear extinction beyond anxiety disorders. Biol Psychiatry. 2009 Mar 15; 65(6):453-4. PMID: 19236997.
      Citations: 2     Fields:    Translation:Humans
    38. Martínez KG, Pérez EA, Ramírez R, Canino G, Rand C. The role of caregivers' depressive symptoms and asthma beliefs on asthma outcomes among low-income Puerto Rican children. J Asthma. 2009 Mar; 46(2):136-41. PMID: 19253118.
      Citations: 12     Fields:    Translation:Humans
    39. Suau GM, Martínez KG. Risk of serotonin syndrome with complementary and alternative medicines: importance to child and adolescent psychiatry. Bol Asoc Med P R. 2009 Jan-Mar; 101(1):47-50. PMID: 19954088.
      Citations:    Fields:    Translation:Humans
    40. Charvolin D, Perez JB, Rouvière F, Giusti F, Bazzacco P, Abdine A, Rappaport F, Martinez KL, Popot JL. The use of amphipols as universal molecular adapters to immobilize membrane proteins onto solid supports. Proc Natl Acad Sci U S A. 2009 Jan 13; 106(2):405-10. PMID: 19116278.
      Citations: 15     Fields:    Translation:Cells
    41. Iversen L, Cherouati N, Berthing T, Stamou D, Martinez KL. Templated protein assembly on micro-contact-printed surface patterns. Use of the SNAP-tag protein functionality. Langmuir. 2008 Jun 17; 24(12):6375-81. PMID: 18484753.
      Citations: 7     Fields:    Translation:HumansCells
    42. Martinez K, Medley CD, Yang CJ, Tan W. Investigation of the hybrid molecular probe for intracellular studies. Anal Bioanal Chem. 2008 Jun; 391(3):983-91. PMID: 18421445.
      Citations: 1     Fields:    Translation:HumansCells
    43. Conlon P, Yang CJ, Wu Y, Chen Y, Martinez K, Kim Y, Stevens N, Marti AA, Jockusch S, Turro NJ, Tan W. Pyrene excimer signaling molecular beacons for probing nucleic acids. J Am Chem Soc. 2008 Jan 09; 130(1):336-42. PMID: 18078339.
      Citations: 33     Fields:    Translation:Cells
    44. Quirk GJ, Martinez KG, Nazario Rodríguez LL. Translating findings from basic fear research to clinical psychiatry in Puerto Rico. P R Health Sci J. 2007 Dec; 26(4):321-8. PMID: 18246959.
      Citations: 5     Fields:    Translation:HumansAnimals
    45. Metten B, Martinez K, Thomas J, Qin W, Smet M, Boens N, Dehaen W. Synthetic routes to 3-alkylsulfanyl-6-aryl-diketopyrrolo[3,4-c]pyrroles--a class of efficient, visible light excitable fluorophores. Org Biomol Chem. 2007 Aug 21; 5(16):2587-91. PMID: 18019533.
      Citations:    Fields:    Translation:Cells
    46. Perez JB, Segura JM, Abankwa D, Piguet J, Martinez KL, Vogel H. Monitoring the diffusion of single heterotrimeric G proteins in supported cell-membrane sheets reveals their partitioning into microdomains. J Mol Biol. 2006 Nov 10; 363(5):918-30. PMID: 16996083.
      Citations: 11     Fields:    Translation:HumansCells
    47. Meyer BH, Martinez KL, Segura JM, Pascoal P, Hovius R, George N, Johnsson K, Vogel H. Covalent labeling of cell-surface proteins for in-vivo FRET studies. FEBS Lett. 2006 Mar 06; 580(6):1654-8. PMID: 16497304.
      Citations: 4     Fields:    Translation:HumansCells
    48. Meyer BH, Segura JM, Martinez KL, Hovius R, George N, Johnsson K, Vogel H. FRET imaging reveals that functional neurokinin-1 receptors are monomeric and reside in membrane microdomains of live cells. Proc Natl Acad Sci U S A. 2006 Feb 14; 103(7):2138-43. PMID: 16461466.
      Citations: 67     Fields:    Translation:HumansCells
    49. Schreiter C, Gjoni M, Hovius R, Martinez KL, Segura JM, Vogel H. Reversible sequential-binding probe receptor-ligand interactions in single cells. Chembiochem. 2005 Dec; 6(12):2187-94. PMID: 16270372.
      Citations: 3     Fields:    Translation:Cells
    50. Lill Y, Martinez KL, Lill MA, Meyer BH, Vogel H, Hecht B. Kinetics of the initial steps of G protein-coupled receptor-mediated cellular signaling revealed by single-molecule imaging. Chemphyschem. 2005 Aug 12; 6(8):1633-40. PMID: 16082665.
      Citations: 9     Fields:    Translation:HumansCells
    51. Tan L, Li Y, Drake TJ, Moroz L, Wang K, Li J, Munteanu A, Chaoyong JY, Martinez K, Tan W. Molecular beacons for bioanalytical applications. Analyst. 2005 Jul; 130(7):1002-5. PMID: 15965520.
      Citations: 10     Fields:    
    52. Geissbuehler I, Hovius R, Martinez KL, Adrian M, Thampi KR, Vogel H. Lipid-coated nanocrystals as multifunctionalized luminescent scaffolds for supramolecular biological assemblies. Angew Chem Int Ed Engl. 2005 Feb 18; 44(9):1388-92. PMID: 15674994.
      Citations: 5     Fields:    Translation:Cells
    53. Martínez KG, Guiot HM, Casas-Dolz I, González-Tejera G, Colón de Martí LN. Applicability of the Spanish Translation of the Zung Self-Rating Depression Scale in a general Puerto Rican population. P R Health Sci J. 2003 Jun; 22(2):179-85. PMID: 12866143.
      Citations:    Fields:    Translation:Humans
    54. Martinez KL, Gohon Y, Corringer PJ, Tribet C, Mérola F, Changeux JP, Popot JL. Allosteric transitions of Torpedo acetylcholine receptor in lipids, detergent and amphipols: molecular interactions vs. physical constraints. FEBS Lett. 2002 Sep 25; 528(1-3):251-6. PMID: 12297315.
      Citations: 19     Fields:    Translation:AnimalsCells
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