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Omonike Olaleye

TitleAssociate Professor of Pharmacology
Faculty RankAssociate Professor of Pharmacology
InstitutionTexas Southern University
DepartmentPharmaceutical Sciences
Address3100 Cleburne St.
Houston TX 77004
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    Other Positions
    TitleAdjunct Faculty
    InstitutionUniversity of St. Thomas

    TitleAssistant Affiliate Member
    InstitutionThe Methodist Hospital Research Institute
    DepartmentInfectious Diseases

    TitleAdjunct Faculty
    InstitutionUT Health
    DepartmentPathology and Laboratory Medicine

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    Collapse Biography 
    Collapse awards and honors
    2005 - 2007NASA JPFP Pre-doctoral Fellow, UNCF NASASpecial Programs
    2005 - 2007UNCF*Merck Graduate Fellow, UNCF*Merck
    2006NASA Mini Research Award, NASA
    2009 - 2010TSU Faculty Seed Grant, Texas Southern University
    2010 - 2012Center for AIDS Research Award, Baylor College of Medicine
    2010 - 2011RTRN Small Grants Program Award , RCMI
    2011 - 2014R. A. Welch Foundation Chemistry and Biology Collaborative Grant , John S. Dunn Gulf Coast Consortium for Chemical Genomics

    Collapse Overview 
    Collapse overview
    Our lab is focused on evaluation of Methionine Aminopeptidase inhibitor Libraries in Leishmania major. N-terminal processing of proteins is an essential process in all organisms. Therefore, inhibiting MetAP function will shed light on the physiological role of MetAP in parasite microbiology and facilitate the future design of novel anti-parasitic agents. I am particularly well-suited to be a collaborating PI on this grant. I have the expertise, background and insight necessary to successfully collaborate on this project. I have a well-rounded background in molecular biology, chemical biology, pharmacology and synthetic chemistry both in industry and academia which are the fundamental skills necessary to lead, implement and successfully complete this project. While I was at Johns Hopkins University School of Medicine, I successfully cloned, over-expressed and purified to near homogeneity the two MetAPs from M. tuberculosis as described in the publication in Chemistry & Biology (3); and the only MetAP in E. faecalis. Using a High-throughput screening approach, I screened a library of 175,000 structurally diverse small molecules and identified novel potent inhibitors of these MetAPs that show either selective or cross-reactive activity relative to host MetAPs. In addition, as a graduate student in collaboration with Dr. Brian Mathews at the University of Oregon, we solved and published the first X-ray structure of MtMetAP1c from Mtb (5). Moreover, in collaboration with the Johns Hopkins TB Research Center I successfully validated some of the TB MetAP inhibitors using a chemical genomics approach. Prior to starting graduate school, I worked in at Merck Research Laboratories and Bristol-Meyers Squibb (4) on projects aimed at the synthesis and the design of potential drug candidates for testing in biological assays. Because of all these past experiences, I have had the exposure to many critical steps involved in drug discovery and the importance of multidisciplinary collaborations and communication. Therefore, I have established collaborations with Dr. Rosa Maldonado at UT El Paso to evaluate the MetAP inhibitors in in vitro and in vivo models of infection. Together, we have a well-rounded collaborative team with expertise that will successfully accomplish the proposed study. We have made recent progress in identifying novel MetAP inhibitors with activity against L. Major. This promising result will give us more insight to the relevance of N-terminal protein processing in L. Major.

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Onyenaka C, Idowu KA, Ha NP, Graviss EA, Olaleye OA. Anti-Tuberculosis Potential of OJT008 against Active and Multi-Drug-Resistant Mycobacterium Tuberculosis: In Silico and In Vitro Inhibition of Methionine Aminopeptidase. Int J Mol Sci. 2023 Dec 05; 24(24). PMID: 38138972.
      Citations:    Fields:    Translation:HumansCells
    2. Dongarwar D, Ajewole V, Spooner KK, Tran V, Adebusuyi T, Onyenaka C, Bakare O, Emeh C, Baines K, Boua D, Mossi Y, Egbejimi A, Ibrahim S, Olaleye O, Salihu HM. Racial and Ethnic Disparities in Stillbirth among Pregnant Women with Obesity. Am J Perinatol. 2023 Jun 26. PMID: 37230474.
      Citations:    Fields:    
    3. Egbejimi A, Ajewole V, Dongarwar D, Kaur M, Phillips M, Liang J, Fadel M, Lota L, Simon J, Otule M, Taylor K, Oguibe G, Salihu HM, Olaleye O. Racial Disparities in Preterm Birth among Pregnant Women with Obesity. South Med J. 2023 06; 116(6):471-477. PMID: 37263609.
      Citations:    Fields:    Translation:Humans
    4. Olaleye OA, Zash R, Diseko M, Mayondi G, Mabuta J, Lockman S, Melton ML, Mmalane M, Makhema J, Shapiro RL. Impact of prophylactic antimalarials in pregnant women living with Human Immunodeficiency Virus?on birth outcomes in Botswana. Trop Med Int Health. 2022 11; 27(11):990-998. PMID: 36183175.
      Citations:    Fields:    Translation:HumansCells
    5. Idowu KA, Onyenaka C, Olaleye OA. A computational evaluation of structural stability of omicron and delta mutations of SARS-CoV-2 spike proteins and human ACE-2 interactions. Inform Med Unlocked. 2022; 33:101074. PMID: 36092780.
    6. Tavera G, Dongarwar D, Salemi JL, Akindela O, Osazuwa I, Akpan EB, Okolie U, Johnson M, Spooner KK, Akpan UI, Yusuf KK, Chukwudum C, Salihu HM, Olaleye OA. Diabetes in pregnancy and risk of near-miss, maternal mortality and foetal outcomes in the USA: a retrospective cross-sectional analysis. J Public Health (Oxf). 2022 08 25; 44(3):549-557. PMID: 33866358.
      Citations: 2     Fields:    Translation:Humans
    7. Fernandes P, Wang K, Timmerman J, Reyes A, Holmes F, Olaleye OA, Salihu HM, Moerchen VA, Belcher HME, Copeland-Linder N, Noble CA, Vamos CA, Armstrong A, Waters CR, Long-White D, Brown C, Reddy MM, Kuo A. Success of Maternal and Child Health Pipeline Training Programs: Alumni Survey Results. Matern Child Health J. 2022 Aug; 26(Suppl 1):69-77. PMID: 35821359.
      Citations:    Fields:    Translation:Humans
    8. Olaleye OA, Dongarwar D, Salihu HM, Adu-Gyamfi S, Kaur M, Egbejimi A, Moerchen VA, Belcher HME, Holmes F, Kuo A, Copeland-Linder N, Noble CA, Vamos CA, Waters CR, Brown CM, Reddy MM. HRSA-Funded MCH Pipeline Training Program: Advancing the MCH Pipeline and Workforce Through Research Collaborations. Matern Child Health J. 2022 Aug; 26(Suppl 1):147-155. PMID: 35796850.
      Citations: 1     Fields:    Translation:Humans
    9. Rincon Nigro ME, Du T, Gao S, Kaur M, Xie H, Olaleye OA, Liang D. Metabolite Identification of a Novel Anti-Leishmanial Agent OJT007 in Rat Liver Microsomes Using LC-MS/MS. Molecules. 2022 Apr 30; 27(9). PMID: 35566205.
      Citations: 4     Fields:    Translation:AnimalsCells
    10. Kehinde IA, Egbejimi A, Kaur M, Onyenaka C, Adebusuyi T, Olaleye OA. Inhibitory mechanism of Ambroxol and Bromhexine Hydrochlorides as potent blockers of molecular interaction between SARS-CoV-2 spike protein and human angiotensin-converting Enzyme-2. J Mol Graph Model. 2022 07; 114:108201. PMID: 35487151.
      Citations: 6     Fields:    Translation:HumansCells
    11. Belcher HME, Copeland-Linder N, Stone J, Waters CR, Kuo A, Moerchen V, Olaleye O, Salihu HM, Vamos C, Brown C, Reddy MM. MCH Pipeline Training Program: Connecting with Academia to Build Capacity Through Mentoring. Matern Child Health J. 2022 Aug; 26(Suppl 1):37-43. PMID: 35325352.
      Citations: 1     Fields:    Translation:Humans
    12. Kehinde IA, Egbeyemi A, Kaur M, Onyenaka C, Adebusuyi T, Olaleye OA. Inhibitory mechanism of clioquinol and its derivatives at the exopeptidase site of human angiotensin-converting enzyme-2 and receptor binding domain of SARS-CoV-2 viral spike. J Biomol Struct Dyn. 2023 04; 41(7):2992-3001. PMID: 35220925.
      Citations: 3     Fields:    Translation:HumansCells
    13. Fernandes P, Wang K, Timmerman J, Reyes A, Holmes F, Olaleye OA, Salihu HM, Moerchen VA, Belcher HME, Copeland-Linder N, Noble CA, Vamos CA, Armstrong A, Waters CR, Long-White D, Brown C, Reddy MM, Kuo A. Success of Maternal and Child Health Pipeline Training Programs: Alumni Survey Results. Matern Child Health J. 2022 Jul; 26(7):1415-1423. PMID: 35192126.
      Citations: 1     Fields:    Translation:Humans
    14. Ikedionwu CA, Dongarwar D, Williams C, Odeh E, Peh MPN, Hooker H, Wiseman S, Brock T, Payne-Green E, Chukwudum C, Loudd G, Shelton A, Atkinson JO, Spooner KK, Salemi JL, Salihu HM, Olaleye OA. Trends and Risk Factors for Leishmaniasis among Reproductive Aged Women in the United States. Int J MCH AIDS. 2021; 10(2):166-173. PMID: 34386298.
    15. Rincon Nigro M, Ma J, Awosemo OT, Xie H, Olaleye OA, Liang D. Development and Validation of a Sensitive, Specific and Reproducible UPLC-MS/MS Method for the Quantification of OJT007, A Novel Anti-Leishmanial Agent: Application to a Pharmacokinetic Study. Int J Environ Res Public Health. 2021 04 27; 18(9). PMID: 33925369.
      Citations: 1     Fields:    Translation:Animals
    16. Dongarwar D, Ajewole VB, Harris K, Oduguwa E, Ofili TU, Onyenaka C, Arnold S, Broussard J, Ishioye J, Marshal J, Mayoya J, Le D, Fadel M, Olaleye OA, Salihu HM. A Framework for Protecting Pregnant Women in the Era of COVID-19 Pandemic. Int J MCH AIDS. 2021; 10(1):109-112. PMID: 33868776.
    17. Olaleye OA, Kaur M, Onyenaka C, Adebusuyi T. Discovery of Clioquinol and analogues as novel inhibitors of Severe Acute Respiratory Syndrome Coronavirus 2 infection, ACE2 and ACE2 - Spike protein interaction in vitro. Heliyon. 2021 Mar; 7(3):e06426. PMID: 33732940.
    18. Harris K, Dongarwar D, Roshan T, Onyenaka C, Enwerem C, Olaleye O, Salihu HM. The Global Alliance for Maternal and Child Health (GLAM): A Pioneer Organization for MCH Students. Int J MCH AIDS. 2021; 10(1):66-69. PMID: 33442493.
    19. Alexander J, Dongarwar D, Oduguwa E, Varnado L, Adenote A, Bailey J, Ezeudu C, Nelson P, Shavers A, Telufusi A, Spooner KK, Salemi JL, Olaleye OA, Salihu HM. Temporal trends of gestational malaria in the United States. Parasite Epidemiol Control. 2020 Nov; 11:e00191. PMID: 33997355.
    20. Darlington F, Acha BM, Roshan T, Ikeanyionwu C, Kutse S, Abajue U, Osazuwa B, Gomez I, Spooner KK, Salemi JL, Dongarwar D, Olaleye OA, Salihu HM, Ndefo UA. Opioid-Related Disorders Among Pregnant Women with Sickle Cell Disease and Adverse Pregnancy Outcomes. Pain Med. 2020 11 01; 21(11):3087-3093. PMID: 32710119.
      Citations: 1     Fields:    Translation:Humans
    21. Olaleye OA, Kaur M, Onyenaka CC. Ambroxol Hydrochloride Inhibits the Interaction between Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein's Receptor Binding Domain and Recombinant Human ACE2. bioRxiv. 2020 Sep 14. PMID: 32995775.
    22. Olaleye OA, Kaur M, Onyenaka C, Adebusuyi T. Discovery of Clioquinol and Analogues as Novel Inhibitors of Severe Acute Respiratory Syndrome Coronavirus 2 Infection, ACE2 and ACE2 - Spike Protein Interaction In Vitro. bioRxiv. 2020 Aug 14. PMID: 32817951.
    23. Ajewole VB, Ngujede AE, Oduguwa E, Dongarwar D, Kaur M, Knight C, Jackson M, Nguyen U, Roshan T, Simpson J, Vouffo I, Olaleye OA, Salihu HM. A Surveillance System for the Maternal and Child Health (MCH) Population During the COVID-19 Pandemic. Int J MCH AIDS. 2020; 9(3):350-353. PMID: 32832200.
    24. Thompson J, Onyenaka C, Oduguwa E, Dongarwar D, Gendra S, Coker V, Kutse S, Blanco M, Nwangwu O, King C, Enamorado E, Bakare O, Ajewole VB, Spooner KK, Salemi JL, Aliyu MH, Salihu HM, Olaleye OA. Trends and Racial/Ethnic Disparities in the Rates of Pre-eclampsia by HIV Status in the US. J Racial Ethn Health Disparities. 2021 06; 8(3):670-677. PMID: 32754847.
      Citations: 1     Fields:    Translation:Humans
    25. Dongarwar D, Taylor J, Ajewole V, Anene N, Omoyele O, Ogba C, Oluwatoba A, Giger D, Thuy A, Argueta E, Naik E, Salemi JL, Spooner K, Olaleye O, Salihu HM. Trends in Appendicitis Among Pregnant Women, the Risk for Cardiac Arrest, and Maternal-Fetal Mortality. World J Surg. 2020 Dec; 44(12):3999-4005. PMID: 32737556.
      Citations:    Fields:    Translation:Humans
    26. Dongarwar D, Ajewole VB, Oduguwa E, Ngujede A, Harris K, Ofili TU, Olaleye OA, Salihu HM. Role of Social Determinants of Health in Widening Maternal and Child Health Disparities in the Era of Covid-19 Pandemic. Int J MCH AIDS. 2020; 9(3):316-319. PMID: 32765962.
    27. Ikedionwu C, Dongarwar D, Kaur M, Nunez L, Awazi A, Mallet J, Kennedy K, Cano M, Dike C, Okwudi J, Stewart J, Igwegbe D, Estes FG, Spooner KK, Salemi JL, Salihu HM, Olaleye OA. Trends and associated characteristics for Chagas disease among women of reproductive age in the United States, 2002 to 2017. Parasite Epidemiol Control. 2020 Nov; 11:e00167. PMID: 32743081.
    28. Nguyen NH, Le EN, Mbah VO, Welsh EB, Daas R, Spooner KK, Salemi JL, Olaleye OA, Salihu HM. Opioid Use Among HIV-Positive Pregnant Women and the Risk for Maternal-Fetal Complications. South Med J. 2020 06; 113(6):292-297. PMID: 32483639.
      Citations:    Fields:    Translation:Humans
    29. Rodriguez F, John SF, Iniguez E, Montalvo S, Michael K, White L, Liang D, Olaleye OA, Maldonado RA. In Vitro and In Vivo Characterization of Potent Antileishmanial Methionine Aminopeptidase 1 Inhibitors. Antimicrob Agents Chemother. 2020 05 21; 64(6). PMID: 32179532.
      Citations: 5     Fields:    Translation:Animals
    30. Salihu H, Dongarwar D, Ikedionwu CA, Shelton A, Jenkins CM, Onyenaka C, Charles C, Wang H, Osemene I, Harris KJ, Kaur M, Rasmus M, Awosemo O, Milton S, Estill S, Adebusuyi T, Gao X, Mbye YFN, Chen Y, Olaleye OA. Racial/Ethnic Disparities in the Burden of HIV/Cervical Cancer Comorbidity and Related In-hospital Mortality in the USA. J Racial Ethn Health Disparities. 2021 02; 8(1):24-32. PMID: 32378158.
      Citations: 2     Fields:    Translation:Humans
    31. Ekpenyong O, Gao X, Ma J, Cooper C, Nguyen L, Olaleye OA, Liang D, Xie H. Pre-Clinical Pharmacokinetics, Tissue Distribution and Physicochemical Studies of CLBQ14, a Novel Methionine Aminopeptidase Inhibitor for the Treatment of Infectious Diseases. Drug Des Devel Ther. 2020; 14:1263-1277. PMID: 32280198.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    32. Erwin ER, Addison AP, John SF, Olaleye OA, Rosell RC. Pharmacokinetics of isoniazid: The good, the bad, and the alternatives. Tuberculosis (Edinb). 2019 05; 116S:S66-S70. PMID: 31076322.
      Citations: 14     Fields:    Translation:HumansAnimals
    33. Salihu HM, Henshaw C, Salemi JL, Dongarwar D, Wudil UJ, Olaleye O, Godbole N, Aggarwal A, Aliyu MH. Temporal trends and black-white disparity in mortality among hospitalized persons living with HIV in the United States. Medicine (Baltimore). 2019 Mar; 98(9):e14584. PMID: 30817575.
      Citations: 1     Fields:    Translation:HumansCells
    34. Ekpenyong O, Cooper C, Ma J, Liang D, Olaleye O, Xie H. A simple, sensitive and reliable LC-MS/MS method for the determination of 7-bromo-5-chloroquinolin-8-ol (CLBQ14), a potent and selective inhibitor of methionine aminopeptidases: Application to pharmacokinetic studies. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Oct 15; 1097-1098:35-43. PMID: 30199748.
      Citations: 3     Fields:    Translation:Animals
    35. Dennis EM, Hao Y, Tamambang M, Roshan TN, Gatlin KJ, Bghigh H, Ogunyemi OT, Diallo F, Spooner KK, Salemi JL, Olaleye OA, Khan KZ, Aliyu MH, Salihu HM. Tuberculosis during pregnancy in the United States: Racial/ethnic disparities in pregnancy complications and in-hospital death. PLoS One. 2018; 13(3):e0194836. PMID: 29579086.
      Citations: 12     Fields:    Translation:Humans
    36. Prophet J, Kelly K, Domingo J, Ayeni H, Mekouguem XPD, Dockery B, Allam F, Kaur M, Artis J, Spooner KK, Salemi JL, Olaleye OA, Salihu HM. Severe pre-eclampsia among pregnant women with sickle cell disease and HIV. Pregnancy Hypertens. 2018 Jan; 11:87-91. PMID: 29523281.
      Citations: 5     Fields:    Translation:Humans
    37. Fernandez D, Salami I, Davis J, Mbah F, Kazeem A, Ash A, Babino J, Carter L, Salemi JL, Spooner KK, Olaleye OA, Salihu HM. HIV-TB Coinfection among 57 Million Pregnant Women, Obstetric Complications, Alcohol Use, Drug Abuse, and Depression. J Pregnancy. 2018; 2018:5896901. PMID: 29507814.
      Citations: 7     Fields:    Translation:HumansPHPublic Health
    38. Falana A, Akpojiyovwi V, Sey E, Akpaffiong A, Agumbah O, Chienye S, Banks J, Jones E, Spooner KK, Salemi JL, Olaleye OA, Onyiego SD, Salihu HM. Hospital length of stay and cost burden of HIV, tuberculosis, and HIV-tuberculosis coinfection among pregnant women in the United States. Am J Infect Control. 2018 05; 46(5):564-570. PMID: 29108662.
      Citations: 5     Fields:    Translation:Humans
    39. John SF, Aniemeke E, Ha NP, Chong CR, Gu P, Zhou J, Zhang Y, Graviss EA, Liu JO, Olaleye OA. Characterization of 2-hydroxy-1-naphthaldehyde isonicotinoyl hydrazone as a novel inhibitor of methionine aminopeptidases from Mycobacterium tuberculosis. Tuberculosis (Edinb). 2016 12; 101S:S73-S77. PMID: 27856197.
      Citations: 8     Fields:    Translation:HumansCells
    40. Vijayakumar S, Finney John S, Nusbaum RJ, Ferguson MR, Cirillo JD, Olaleye O, Endsley JJ. In vitro model of mycobacteria and HIV-1 co-infection for drug discovery. Tuberculosis (Edinb). 2013 Dec; 93 Suppl:S66-70. PMID: 24388652.
      Citations: 4     Fields:    Translation:HumansCells
    41. Bhat S, Olaleye O, Meyer KJ, Shi W, Zhang Y, Liu JO. Analogs of N'-hydroxy-N-(4H,5H-naphtho[1,2-d]thiazol-2-yl)methanimidamide inhibit Mycobacterium tuberculosis methionine aminopeptidases. Bioorg Med Chem. 2012 Jul 15; 20(14):4507-13. PMID: 22704656.
      Citations: 2     Fields:    Translation:Cells
    42. Olaleye O, Raghunand TR, Bhat S, Chong C, Gu P, Zhou J, Zhang Y, Bishai WR, Liu JO. Characterization of clioquinol and analogues as novel inhibitors of methionine aminopeptidases from Mycobacterium tuberculosis. Tuberculosis (Edinb). 2011 Dec; 91 Suppl 1:S61-5. PMID: 22115541.
      Citations: 15     Fields:    Translation:HumansCells
    43. Olaleye O, Raghunand TR, Bhat S, He J, Tyagi S, Lamichhane G, Gu P, Zhou J, Zhang Y, Grosset J, Bishai WR, Liu JO. Methionine aminopeptidases from Mycobacterium tuberculosis as novel antimycobacterial targets. Chem Biol. 2010 Jan 29; 17(1):86-97. PMID: 20142044.
      Citations: 22     Fields:    Translation:HumansCells
    44. Olaleye OA, Bishai WR, Liu JO. Targeting the role of N-terminal methionine processing enzymes in Mycobacterium tuberculosis. Tuberculosis (Edinb). 2009 Dec; 89 Suppl 1:S55-9. PMID: 20006307.
      Citations: 6     Fields:    Translation:HumansCells
    45. Addlagatta, A., Quillin, M.L., Omotoso, O., Liu, J.O., and Matthews, B.W. . Identification of an SH3 Binding Motif in a New Class of Methionine Aminopeptidase from Mycobacterium tuberculosis Suggests a Mode of Interaction with the Ribosome. Biochemistry. 2005; 44:7166-7174.
    46. Kempson, J, Pitts, WJ, Barbosa, J, Guo, J, Omotoso, O, Watson, A, Stebbins, K., Starling, GC, Dodd, JH, Barrish, JC, Felix, R, and Fischer, K. . Fused pyrimidine based inhibitors of phosphodiesterase 7 (PDE7): Synthesis and initial structure-activity relationships. Bioorg. Med. Chem. Lett. 2005; (15):1829-1833.
    47. Addlagatta, A., Quillin, M.L., Omotoso, O., Liu, J.O., and Matthews, B.W. . Identification of an SH3 Binding Motif in a New Class of Methionine Aminopeptidase from Mycobacterium tuberculosis Suggests a Mode of Interaction with the Ribosome. Biochemistry. 2005; 44:7166-7174.
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