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Maria Lima

TitleDean, School of Graduate Studies and Research
InstitutionMeharry Medical College
DepartmentMicrobiology and Immunology
AddressSchool of Graduate Studies and Research
Meharry Medical College
1005 D. B. Todd Blvd.
Nashville TN 37208
Phone615 327-6533
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    Collapse Biography 
    Collapse awards and honors
    2014William Hinton Research Training Award, American Society for Microbiology
    2013Ph.D. Faculty Member of the Year, Meharry Medical College
    2013Teacher of Exceptional Merit, Meharry Medical College
    2011Ph.D. Faculty Member of the Year, Meharry Medical College
    2009Distinguished Professional Mentor Award, Society for Advancement of Chicanos and Native Americans in Science
    2009Kaiser Permanente Award for Excellence in Teaching, Meharry Medical College
    200710 Women to Watch, Nashville Medical News
    2005Distinguished Faculty Service Award, Meharry Medical College
    1997Exemplary Teacher of the Year, Meharry Medical College

    Collapse Overview 
    Collapse overview
    I am the Dean of the School of Graduate Studies and Research at Meharry Medical College. A graduate of the Ph.D. program in Microbiology at Michigan State University, my post-doctoral education was done at Meharry Medical College/Vanderbilt University in Molecular Parasitology. I am a tenured Professor of Microbiology and Immunology, and my research interest is in tropical diseases; specifically in the area of host-parasite relationships.

    As the Dean of the School of Graduate Studies and Research, I have obtained innovative funding from the National Institutes of Health and the National Science Foundation, which has enhanced graduate training at Meharry Medical College. According to Diverse Issues in Higher Education, over the past 10 years in the United States, the 2nd highest number of African-Americans students who earned Ph.D. degree in Biomedical Sciences graduated from Meharry. This was made possible largely through the funding we received from NIH and NSF.

    I serve as consultant and advisor to the National Institutes of Health, was chair of the Minority Access Research Careers Study Session (MARC) at the National Institute of General Medical Sciences, and a member of the Genome Research Study Section, National Human Genome Research Institute. I also serve on numerous other national committees.

    My goal is to increase the number of underrepresented students who pursue a career in biomedical research. I teach in all Schools (Dentistry, Medical, Graduate) and Programs at Meharry. As a result, I touch the lives of many students as they matriculate through this institution and nationally. I am a student advocate and my door is always open to listen to students concerns. My interaction with students is a source of great joy.

    Collapse Research 
    Collapse research activities and funding
    K14HL003156     (LIMA, MARIA F)May 1, 1994 - Apr 30, 2000
    Role: Principal Investigator

    R25GM051759     (LIMA, MARIA F)Sep 30, 1994 - Sep 30, 2002
    Role: Principal Investigator

    U54MD007586     (ADUNYAH, SAMUEL E.)Sep 30, 1997 - Jun 30, 2022
    The RCMI Program in Health Disparities Research at Meharry Medical College
    Role: Co-Principal Investigator

    R25GM059994     (MOTLEY-JOHNSON, EVANGELINE D)Aug 1, 1999 - Jul 31, 2022
    The Meharry RISE initiative
    Role: Co-Principal Investigator

    R13AI049224     (LIMA, MARIA F)Apr 1, 2001 - Mar 31, 2006
    Tropical Diseases Symposium
    Role: Principal Investigator

    R25GM064319     (LIMA, MARIA F)Sep 1, 2001 - Aug 31, 2007
    Meharry/Vanderbilt PREP Initiative
    Role: Principal Investigator

    C06RR022072     (LIMA, MARIA F)Sep 22, 2005 - Jun 30, 2010
    Extramural Research Facilities Construction
    Role: Principal Investigator

    U54MD010722     (WILKINS, CONSUELO HOPKINS)May 19, 2016 - Mar 31, 2021
    Center of Excellence in Precision Medicine and Population Health
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Jerome RN, Pulley JM, Sathe NA, Krishnaswami S, Dickerson AB, Worley KJ, Lima MF, Wilkins CH. Uncovering Outcome Disparities of ß2 Adrenergic Agonists in Blacks: A Systematic Review. J Natl Med Assoc. 2020 Jul 27. PMID: 32732018.
      Citations:    Fields:    
    2. Arun A, Rayford KJ, Cooley A, Rachakonda G, Villalta F, Pratap S, Lima MF, Sheibani N, Nde PN. Thrombospondin-1 Plays an Essential Role in Yes-Associated Protein Nuclear Translocation during the Early Phase of Trypanosoma cruzi Infection in Heart Endothelial Cells. Int J Mol Sci. 2020 Jul 12; 21(14). PMID: 32664627.
      Citations:    Fields:    
    3. Raghunathan S, Patil S, Baxter E, Benson BA, Bleem LE, Crawford TM, Holder GP, McClintock T, Reichardt CL, Varga TN, Whitehorn N, Ade PAR, Allam S, Anderson AJ, Austermann JE, Avila S, Avva JS, Bacon D, Beall JA, Bender AN, Bianchini F, Bocquet S, Brooks D, Burke DL, Carlstrom JE, Carretero J, Castander FJ, Chang CL, Chiang HC, Citron R, Costanzi M, Crites AT, da Costa LN, Desai S, Diehl HT, Dietrich JP, Dobbs MA, Doel P, Everett S, Evrard AE, Feng C, Flaugher B, Fosalba P, Frieman J, Gallicchio J, García-Bellido J, Gaztanaga E, George EM, Giannantonio T, Gilbert A, Gruendl RA, Gschwend J, Gupta N, Gutierrez G, de Haan T, Halverson NW, Harrington N, Henning JW, Hilton GC, Hollowood DL, Holzapfel WL, Honscheid K, Hrubes JD, Huang N, Hubmayr J, Irwin KD, Jeltema T, Kind MC, Knox L, Kuropatkin N, Lahav O, Lee AT, Li D, Lima M, Lowitz A, Maia MAG, Marshall JL, McMahon JJ, Melchior P, Menanteau F, Meyer SS, Miquel R, Mocanu LM, Mohr JJ, Montgomery J, Moran CC, Nadolski A, Natoli T, Nibarger JP, Noble G, Novosad V, Ogando RLC, Padin S, Plazas AA, Pryke C, Rapetti D, Romer AK, Roodman A, Rosell AC, Rozo E, Ruhl JE, Rykoff ES, Saliwanchik BR, Sanchez E, Sayre JT, Scarpine V, Schaffer KK, Schubnell M, Serrano S, Sevilla-Noarbe I, Sievers C, Smecher G, Smith M, Soares-Santos M, Stark AA, Story KT, Suchyta E, Swanson MEC, Tarle G, Tucker C, Vanderlinde K, Veach T, De Vicente J, Vieira JD, Vikram V, Wang G, Wu WLK, Yefremenko V, Zhang Y. Detection of CMB-Cluster Lensing using Polarization Data from SPTpol. Phys Rev Lett. 2019 Nov 01; 123(18):181301. PMID: 31763885.
      Citations:    Fields:    
    4. Ofili EO, Tchounwou PB, Fernandez-Repollet E, Yanagihara R, Akintobi TH, Lee JE, Malouhi M, Garner ST, Hayes TT, Baker AR, Dent AL, Abdelrahim M, Rollins L, Chang SP, Sy A, Hernandez BY, Bullard PL, Noel RJ, Shiramizu B, Hedges JR, Berry MJ, Bond VC, Lima MF, Mokuau N, Kirken RA, Cruz-Correa M, Sarpong DF, Vadgama J, Yates C, Kahn SA, Soliman KF, Perry G, Pezzano M, Luciano CA, Barnett ME, Oyekan A, Kumar D, Norris KC. The Research Centers in Minority Institutions (RCMI) Translational Research Network: Building and Sustaining Capacity for Multi-Site Basic Biomedical, Clinical and Behavioral Research. Ethn Dis. 2019; 29(Suppl 1):135-144. PMID: 30906162.
      Citations:    Fields:    Translation:Humans
    5. Suman S, Rachakonda G, Mandape SN, Sakhare SS, Villalta F, Pratap S, Lima MF, Nde PN. Phospho-proteomic analysis of primary human colon epithelial cells during the early Trypanosoma cruzi infection phase. PLoS Negl Trop Dis. 2018 09; 12(9):e0006792. PMID: 30222739.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    6. Matthews QL, Farrow AL, Rachakonda G, Gu L, Nde P, Krendelchtchikov A, Pratap S, Sakhare SS, Sabbaj S, Lima MF, Villalta F. Epitope Capsid-Incorporation: New Effective Approach for Vaccine Development for Chagas Disease. Pathog Immun. 2016 Fall-Winter; 1(2):214-233. PMID: 27709126.
    7. Udoko AN, Johnson CA, Dykan A, Rachakonda G, Villalta F, Mandape SN, Lima MF, Pratap S, Nde PN. Early Regulation of Profibrotic Genes in Primary Human Cardiac Myocytes by Trypanosoma cruzi. PLoS Negl Trop Dis. 2016 Jan; 10(1):e0003747. PMID: 26771187.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    8. Farrow AL, Rachakonda G, Gu L, Krendelchtchikova V, Nde PN, Pratap S, Lima MF, Villalta F, Matthews QL. Immunization with Hexon modified adenoviral vectors integrated with gp83 epitope provides protection against Trypanosoma cruzi infection. PLoS Negl Trop Dis. 2014 Aug; 8(8):e3089. PMID: 25144771.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    9. Johnson CA, Rachakonda G, Kleshchenko YY, Nde PN, Madison MN, Pratap S, Cardenas TC, Taylor C, Lima MF, Villalta F. Cellular response to Trypanosoma cruzi infection induces secretion of defensin a-1, which damages the flagellum, neutralizes trypanosome motility, and inhibits infection. Infect Immun. 2013 Nov; 81(11):4139-48. PMID: 23980110.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    10. Nde PN, Lima MF, Johnson CA, Pratap S, Villalta F. Regulation and use of the extracellular matrix by Trypanosoma cruzi during early infection. Front Immunol. 2012; 3:337. PMID: 23133440.
      Citations: 13     Fields:    
    11. Johnson CA, Kleshchenko YY, Ikejiani AO, Udoko AN, Cardenas TC, Pratap S, Duquette MA, Lima MF, Lawler J, Villalta F, Nde PN. Thrombospondin-1 interacts with Trypanosoma cruzi surface calreticulin to enhance cellular infection. PLoS One. 2012; 7(7):e40614. PMID: 22808206.
      Citations: 9     Fields:    Translation:AnimalsCells
    12. Nde PN, Johnson CA, Pratap S, Cardenas TC, Kleshchenko YY, Furtak VA, Simmons KJ, Lima MF, Villalta F. Gene network analysis during early infection of human coronary artery smooth muscle cells by Trypanosoma cruzi and Its gp83 ligand. Chem Biodivers. 2010 May; 7(5):1051-64. PMID: 20491065.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    13. Cardenas TC, Johnson CA, Pratap S, Nde PN, Furtak V, Kleshchenko YY, Lima MF, Villalta F. REGULATION of the EXTRACELLULAR MATRIX INTERACTOME by Trypanosoma cruzi. Open Parasitol J. 2010; 4:72-76. PMID: 21499436.
    14. Villalta F, Scharfstein J, Ashton AW, Tyler KM, Guan F, Mukherjee S, Lima MF, Alvarez S, Weiss LM, Huang H, Machado FS, Tanowitz HB. Perspectives on the Trypanosoma cruzi-host cell receptor interactions. Parasitol Res. 2009 Jun; 104(6):1251-60. PMID: 19283409.
      Citations: 13     Fields:    Translation:HumansAnimals
    15. Villalta F, Madison MN, Kleshchenko YY, Nde PN, Lima MF. Molecular analysis of early host cell infection by Trypanosoma cruzi. Front Biosci. 2008 May 01; 13:3714-34. PMID: 18508467.
      Citations: 10     Fields:    Translation:HumansAnimals
    16. Madison MN, Kleshchenko YY, Nde PN, Simmons KJ, Lima MF, Villalta F. Human defensin alpha-1 causes Trypanosoma cruzi membrane pore formation and induces DNA fragmentation, which leads to trypanosome destruction. Infect Immun. 2007 Oct; 75(10):4780-91. PMID: 17635867.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    17. Augustine SA, Kleshchenko YY, Nde PN, Pratap S, Ager EA, Burns JM, Lima MF, Villalta F. Molecular cloning of a Trypanosoma cruzi cell surface casein kinase II substrate, Tc-1, involved in cellular infection. Infect Immun. 2006 Jul; 74(7):3922-9. PMID: 16790765.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    18. Simmons KJ, Nde PN, Kleshchenko YY, Lima MF, Villalta F. Stable RNA interference of host thrombospondin-1 blocks Trypanosoma cruzi infection. FEBS Lett. 2006 Apr 17; 580(9):2365-70. PMID: 16616140.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    19. Lima MF, Alkowni R, Uyemoto JK, Golino D, Osman F, Rowhani A. Molecular analysis of a California strain of Rupestris stem pitting-associated virus isolated from declining Syrah grapevines. Arch Virol. 2006 Sep; 151(9):1889-94. PMID: 16547827.
      Citations: 4     Fields:    Translation:AnimalsCells
    20. Nde PN, Simmons KJ, Kleshchenko YY, Pratap S, Lima MF, Villalta F. Silencing of the laminin gamma-1 gene blocks Trypanosoma cruzi infection. Infect Immun. 2006 Mar; 74(3):1643-8. PMID: 16495535.
      Citations: 22     Fields:    Translation:HumansAnimals
    21. Kleshchenko YY, Moody TN, Furtak VA, Ochieng J, Lima MF, Villalta F. Human galectin-3 promotes Trypanosoma cruzi adhesion to human coronary artery smooth muscle cells. Infect Immun. 2004 Nov; 72(11):6717-21. PMID: 15501810.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    22. Alexander AD, Villalta F, Lima MF. Transforming growth factor alpha binds to Trypanosoma cruzi amastigotes to induce signaling and cellular proliferation. Infect Immun. 2003 Jul; 71(7):4201-5. PMID: 12819119.
      Citations: 4     Fields:    Translation:AnimalsCells
    23. Ghansah TJ, Ager EC, Freeman-Junior P, Villalta F, Lima MF. Epidermal growth factor binds to a receptor on Trypanosoma cruzi amastigotes inducing signal transduction events and cell proliferation. J Eukaryot Microbiol. 2002 Sep-Oct; 49(5):383-90. PMID: 12425525.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    24. Turner CW, Lima MF, Villalta F. Trypanosoma cruzi uses a 45-kDa mucin for adhesion to mammalian cells. Biochem Biophys Res Commun. 2002 Jan 11; 290(1):29-34. PMID: 11779128.
      Citations: 10     Fields:    Translation:AnimalsCells
    25. Villalta F, Smith CM, Ruiz-Ruano A, Lima MF. A ligand that Trypanosoma cruzi uses to bind to mammalian cells to initiate infection. FEBS Lett. 2001 Sep 21; 505(3):383-8. PMID: 11576533.
      Citations: 19     Fields:    Translation:AnimalsCells
    26. Villalta F, Zhang Y, Bibb KE, Pratap S, Burns JM, Lima MF. Signal transduction in human macrophages by gp83 ligand of Trypanosoma cruzi: trypomastigote gp83 ligand up-regulates trypanosome entry through protein kinase C activation. Mol Cell Biol Res Commun. 1999 Jul; 2(1):64-70. PMID: 10527894.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    27. Villalta F, Zhang Y, Bibb KE, Kappes JC, Lima MF. The cysteine-cysteine family of chemokines RANTES, MIP-1alpha, and MIP-1beta induce trypanocidal activity in human macrophages via nitric oxide. Infect Immun. 1998 Oct; 66(10):4690-5. PMID: 9746565.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    28. Villalta F, Zhang Y, Bibb KE, Burns JM, Lima MF. Signal transduction in human macrophages by gp83 ligand of Trypanosoma cruzi: trypomastigote gp83 ligand up-regulates trypanosome entry through the MAP kinase pathway. Biochem Biophys Res Commun. 1998 Aug 10; 249(1):247-52. PMID: 9705866.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    29. Lima MF, Zhang Y, Villalta F. Beta-chemokines that inhibit HIV-1 infection of human macrophages stimulate uptake and promote destruction of Trypanosoma cruzi by human macrophages. Cell Mol Biol (Noisy-le-grand). 1997 Nov; 43(7):1067-76. PMID: 9449540.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    30. Villalta F, Smith CM, Burns JM, Chaudhuri G, Lima MF. Fab' fragments of a mAb to a member of family 2 of trans-sialidases of Trypanosoma cruzi block trypanosome invasion of host cells and neutralize infection by passive immunization. Ann N Y Acad Sci. 1996 Oct 25; 797:242-5. PMID: 8993367.
      Citations: 5     Fields:    Translation:Animals
    31. Villalta F, Ruiz-Ruano A, Valentine AA, Lima MF. Purification of a 74-kilodalton surface glycoprotein from heart myoblasts that inhibits binding and entry of Trypanosoma cruzi into heart cells. Mol Biochem Parasitol. 1993 Oct; 61(2):217-30. PMID: 8264726.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    32. Villalta F, Lima MF, Howard SA, Zhou L, Ruiz-Ruano A. Purification of a Trypanosoma cruzi trypomastigote 60-kilodalton surface glycoprotein that primes and activates murine lymphocytes. Infect Immun. 1992 Aug; 60(8):3025-32. PMID: 1639469.
      Citations: 3     Fields:    Translation:AnimalsCells
    33. Villalta F, Lima MF, Ruiz-Ruano A, Zhou L. Attachment of Trypanosoma cruzi to host cells: a monoclonal antibody recognizes a trypomastigote stage-specific epitope on the gp 83 required for parasite attachment. Biochem Biophys Res Commun. 1992 Jan 15; 182(1):6-13. PMID: 1370617.
      Citations: 11     Fields:    Translation:AnimalsCells
    34. Ruiz-Ruano A, Villalta F, Lima MF. Changes in polypeptide expression following Trypanosoma cruzi differentiation from trypomastigotes to amastigotes. Biochem Int. 1991 Sep; 25(1):101-8. PMID: 1772436.
      Citations:    Fields:    Translation:AnimalsCells
    35. Villalta F, Lima MF, Zhou L. Purification of Trypanosoma cruzi surface proteins involved in adhesion to host cells. Biochem Biophys Res Commun. 1990 Oct 30; 172(2):925-31. PMID: 2241980.
      Citations: 5     Fields:    Translation:AnimalsCells
    36. Lima MF, Villalta F. Trypanosoma cruzi receptors for human transferrin and their role. Mol Biochem Parasitol. 1990 Jan 15; 38(2):245-52. PMID: 2183049.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    37. Lima MF, Villalta F. Trypanosoma cruzi trypomastigote clones differentially express a parasite cell adhesion molecule. Mol Biochem Parasitol. 1989 Mar 01; 33(2):159-70. PMID: 2657421.
      Citations: 28     Fields:    Translation:AnimalsCells
    38. Lima MF, Villalta F. Host-cell attachment by Trypanosoma cruzi: identification of an adhesion molecule. Biochem Biophys Res Commun. 1988 Aug 30; 155(1):256-62. PMID: 3046614.
      Citations: 11     Fields:    Translation:HumansAnimals
    39. Lima MF, Beltz LA, Kierszenbaum F. Trypanosoma cruzi: a specific surface marker for the amastigote form. J Protozool. 1988 Feb; 35(1):108-10. PMID: 2835480.
      Citations:    Fields:    Translation:AnimalsCells
    40. Lima MF, Kierszenbaum F. Lactoferrin effects of phagocytic cell function. II. The presence of iron is required for the lactoferrin molecule to stimulate intracellular killing by macrophages but not to enhance the uptake of particles and microorganisms. J Immunol. 1987 Sep 01; 139(5):1647-51. PMID: 3114372.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    41. Lima MF, Kierszenbaum F. Lactoferrin effects on the interaction of blood forms of Trypanosoma cruzi with mononuclear phagocytes. Int J Parasitol. 1987 Aug; 17(6):1205-8. PMID: 3308727.
      Citations:    Fields:    Translation:AnimalsCells
    42. Kierszenbaum F, Lima MF, Wirth JJ. Effects of antiserum to Trypanosoma cruzi on the uptake and rate of killing of vector-borne, metacyclic forms of the parasite by macrophages. Int J Parasitol. 1985 Aug; 15(4):409-13. PMID: 2993180.
      Citations: 3     Fields:    Translation:AnimalsCells
    43. Lima MF, Kierszenbaum F. Lactoferrin effects on phagocytic cell function. I. Increased uptake and killing of an intracellular parasite by murine macrophages and human monocytes. J Immunol. 1985 Jun; 134(6):4176-83. PMID: 3886800.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    44. Lima MF, Kierszenbaum F. Effects of treatment of trypomastigote forms of Trypanosoma cruzi or host cells with ethidium bromide on cell infection and intracellular fate of the parasite. J Parasitol. 1984 Dec; 70(6):911-7. PMID: 6396395.
      Citations: 1     Fields:    Translation:AnimalsCells
    45. Lima MF, Kierszenbaum F. Lysis of vector-transmissible, metacyclic forms of Trypanosoma cruzi by avian serum. J Parasitol. 1984 Feb; 70(1):155-6. PMID: 6429306.
      Citations: 3     Fields:    Translation:Animals
    46. Kierszenbaum F, Lima MF. Susceptibility of insect-borne, metacyclic forms of Trypanosoma cruzi to antibody-mediated mechanisms of destruction. Am J Trop Med Hyg. 1983 Nov; 32(6):1236-41. PMID: 6418013.
      Citations: 6     Fields:    Translation:AnimalsCells
    47. Lima MF, Kierszenbaum F. Biochemical requirements for intracellular invasion by Trypanosoma cruzi: protein synthesis. J Protozool. 1982 Nov; 29(4):566-70. PMID: 6757413.
      Citations: 6     Fields:    Translation:AnimalsCells
    48. Szarfman A, Terranova VP, Rennard SI, Foidart JM, de Fatima Lima M, Scheinman JI, Martin GR. Antibodies to laminin in Chagas' disease. J Exp Med. 1982 Apr 01; 155(4):1161-71. PMID: 6801186.
      Citations: 37     Fields:    Translation:HumansAnimals
    49. Peralta JM, Gill K, Cordeiro Lima MF, Coura JR. Leucocyte migration inhibition response to tissue antigens in asymptomatic individuals infected with Trypanosoma cruzi. Clin Exp Immunol. 1981 Sep; 45(3):621-6. PMID: 6802533.
      Citations:    Fields:    Translation:HumansAnimalsCells
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