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Amosy M'Koma

AddressMMC, 1005 Dr. D. B. Todd Jr. Boulevard
VICC, Vanderbilt-Ingram Cancer Center
Nashville TN 37208
Phone615-327-6796
Fax615-327-6442
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    Collapse Biography 
    Collapse education and training
    Kharkov Medical Institute, UKRAINEMD1984Medicine
    Karolinska Hospital, Huddinge, SWEDENResidency1990Surgery
    Karolinska Nobel Institute, SWEDENLicentiate1999Surgery
    Karolinska Nobel Institute, SWEDENPhD2001Surgery
    Mayo Clinic, Rochester, MN, USARes Fellow2004Surgery, Colon & Rectal
    Vanderbilt Univ Medical Center, USAPostDoc2007Surgery, Urologic & Cancer Biology
    Collapse awards and honors
    2012 - 2012AACR Minority Serving Institution Faculty Scholar in Cancer Research, American Association for Cancer Research
    2011 - 2011AACR Minority Serving Institution Faculty Scholar in Cancer Research, American Association for Cancer Research
    2011 - 2016The Early Detection Research Network (EDRN), Data Management Center (DMCC), National Institute of Health/NCI
    2009 - 2009The New Jersey Society of Colon and Rectal Surgeons, Best Basic Science Presentation Poster , American Society of Colon and Rectal Surgeons
    2009 - 2010Research Foundation’s 2009 LPG Grant, American Society of Colon and Rectal Surgeons
    2009 - 2016Affiliated Scientific Investigator, American Society of Colon and Rectal Surgeons
    2005 - 2007Institutional Research & Academic Career Development (IRACDA), National Institute of Health / NIGMS
    2010 - 2013Clinical and Translational Research (VICTR), NIH/CTSA Vanderbilt Institute
    1999 - 2003Swedish Committee of Inquiry into HIV/AIDS (Statens offentliga utredningar, S 2002:11), Swedish Government
    1999 - 2003Partenariat Européen entre communautés africaines, European Union, DGV
    1999 - 2002Migration and Health issues, Swedish Institute of Public Health
    2014 - 2016 Membership Committee: Recommends member categories and criteria to the Executive Council worldwide, American Society of Colon and Rectal Surgeons
    2015 - 2015Recognition of Research, “World Journal of Surgical Procedures” Published by Baishideng Publishing Group Inc.
    2016 - 2016The New England Society of Colon and Rectal Surgeons, Best Clinical Podium Presentation, American Society of Colon and Rectal Surgeons
    2013 - 20155R21 DK095186, National Institute of Health/NIDDK
    2014 - 2020Vice-Chair-Institutional Review Board (IRB), Meharry Medical College
    2020 - 2021Chair - Institutional Review Board (IRB), Meharry Medical College
    2020US Patent - Methods for Diagnosing & Treating IBD (16/571,034,2020), Meharry Medical College
    2020US Patent - Targeted DEFA5 antibody and assay methods for diagnosing & treating IBD (WO2018237064A1), Meharry Medical College
    2019 - 2022ASCRS IBD Committee: The Committee facilitates and promotes adoption of best practices, The American Society of Colon and Rectal Surgerons

    Collapse Overview 
    Collapse overview
    My laboratory is specialized in inflammatory bowel disease (IBD), ulcerative colitis (UC) and Crohn’s colitis (CC) and IBD-associated colorectal cancer (CRC) research, more focused on the biopathophysiology of IBD. My particular keen specialty is on diagnostic methodologies and surgical management of IBD, specifically as they relate to the physiology of restorative proctocolectomy (RPC) and ileal pouch anal anastomosis (IPAA). In years I have been interested in investigating the biochemical variable events following surgical treatment of the colitides and familial adenomatous polyposis (FAP). The current research efforts in collaboration with Dr. Richard Caprioli are directed towards developing strategic methodologies based on MALDI MS, proteomics approaches to identify fingerprints that can discriminate inflammatory colitides. An accurate diagnosis prior to initiating medical therapy or performing colectomy is of paramount importance in terms of evidenced personalized medical therapy, surgical intervention and prognosis, as well as delineation of IBD by non-invasive, easier, affordable, accurate and faster screening. This project performs proteomic analyses of UC and CC, using human colon mucosal and submucosal layers in order to identify proteins that are unique and characteristic of different IBD phenotype. Based on our current data, using MALDI MS technology, we have identified several protein spectral peaks of interest that may delineate the inflammatory colitides in endoscopic biopsies. In the future, we will explore the use of one or more of these proteins as a serum biomarker if the protein(s) uncovered is/are secretory and transposable. Over the past years we have established a translational research program in biomarker discoveries focused on Early Detection of IBD associated colorectal malignancy. While maintaining a close collaborative relationship with several other investigators and laboratories at Vanderbilt University, I have now set up a translational research laboratory, The Laboratory of Inflammatory Bowel Disease Research (LIBDR), as a faculty member at Meharry Medical College School of Medicine, Department of Biochemistry and Cancer Biology, Division of Biomedical Sciences to continue these objectives.

    Collapse Research 
    Collapse research activities and funding
    R21DK095186     (M'KOMA, AMOSY EPHREIM)Aug 1, 2013 - Jul 31, 2015
    NIH/NIDDK
    Differentiating Ulcerative Colitis and Crohns Colitis Through Proteomic Patterns
    Role: Principal Investigator

    Collapse Featured Content 
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. James SD, Hawkins AT, Um JW, Ballard BR, Smoot DT, M'Koma AE. The MYTHS of De novo Crohn's Disease After Restorative Proc-tocolectomy with Ileal Pouch-anal Anastomosis for Ulcerative colitis. 2020; 2(3):1-10. View Publication.
    2. Herman AM, Hawkins AT, James SD, Ballard BR, M'Koma AE. Inflammatory Bowel Disease On-Line Web-Based Guide to Health Professionals and Patients in Developing and African Nations. 2020; 2(3):1-11. View Publication.
    3. James SD, Hawkins AT, M'Koma AE. Adenocarcinoma at the Ileostomy Site After a Proctocolectomy for Ulcerative Colitis and/or Familial Adenomatous Polyposis: An Overview. 2018; 6(64):30-40. View Publication.
    4. Hawkins AT, Um JW, M'Koma AE. Adaptive Returns of Deficient Systemic Plasma Immunoglobulin G Levels as Rehabilitation Biomarker After Emergency Colectomy for Fulminant Ulcerative Colitis. Clin Med Insights Gastroenterol. 2017; 10:1179552217746692. PMID: 29276421.
      Citations:    
    5. Williams AD, Korolkova OY, Sakwe AM, Geiger TM, James SD, Muldoon RL, Herline AJ, Goodwin JS, Izban MG, Washington MK, Smoot DT, Ballard BR, Gazouli M, M'Koma AE. Correction: Human alpha defensin 5 is a candidate biomarker to delineate inflammatory bowel disease. PLoS One. 2017; 12(12):e0189551. PMID: 29211779.
      Citations:    Fields:    
    6. Amosy E. M'Koma. Inflammatory Bowel Disease. State-of-the-Art Performance Improvements After Restorative Proctocolectomy for Ulcerative Colitis: Thirty-Year-Benchmark Evaluation. 2017; 1-45. View Publication.
    7. Williams AD, Korolkova OY, Sakwe AM, Geiger TM, James SD, Muldoon RL, Herline AJ, Goodwin JF, Izban MG, Washington MK, Smoot DT, Ballard BR, Gazouli M, M'Koma AE. . Original Resarch. Human Alpha Defensin-5 is a Candidate Biomarker to Delineate Inflammatory Bowel Disease. 2017; 8(12):e017910.
    8. M'Koma AE. Editorial. Editorial Policies and Skills to Solving Diagnostic Delay in Inflammatory Bowel Disease. 2017; 1(1):1. View Publication.
    9. Williams AD, Korolkova OY, Sakwe AM, Geiger TM, James SD, Muldoon RL, Herline AJ, Goodwin JS, Izban MG, Washington MK, Smoot DT, Ballard BR, Gazouli M, M'Koma AE. Human alpha defensin 5 is a candidate biomarker to delineate inflammatory bowel disease. PLoS One. 2017; 12(8):e0179710. PMID: 28817680.
      Citations: 3     Fields:    Translation:Humans
    10. Hawkins AT, Um JW, M'Koma AE. Adaptive Returns of Deficient Systemic Plasma Immunoglobulin G Levels as Rehabilitation Biomarker After Emergency Colectomy for Fulminant Ulcerative Colitis. Original Article. 2017; 1179552217746692. View Publication.
    11. Williams AD, M'Koma AE. Clinics in Surgery. Delineation of inflammatory bowel disease by molecular biometrics: verification versus validation. 2017; (2):1408. View Publication.
    12. Ballard BR, M'Koma AE. Gastrointestinal endoscopy biopsy derived proteomic patterns predict indeterminate colitis into ulcerative colitis and Crohn’s colitis. World J Gastrointest Endosc. 2015; 7(7):670-674. View Publication.
    13. Ballard BR, M'Koma AE. Gastrointestinal endoscopy biopsy derived proteomic patterns predict indeterminate colitis into ulcerative colitis and Crohn's colitis. World J Gastrointest Endosc. 2015 Jun 25; 7(7):670-4. PMID: 26140094.
      Citations:    
    14. Korolkova OY, Myers JN, Pellom ST, Wang L, M'Koma AE. Characterization of Serum Cytokine Profile in Predominantly Colonic Inflammatory Bowel Disease to Delineate Ulcerative and Crohn's Colitides. Clin Med Insights Gastroenterol. 2015; 8:29-44. PMID: 26078592.
      Citations:    
    15. Korolkova OY, Myers JN, Pellom ST, Wang L, M'Koma AE. Characterization of Serum Cytokine Profile in Predominantly Colonic Inflammatory Bowel Disease to Delineate Ulcerative and Crohn's Colitides. Clin Med Insights Gastroenterol. 2015; 8:29-44. View Publication.
    16. M'Koma AE. Diagnosis of inflammatory bowel disease: Potential role of molecular biometrics. e-Book: World Clinical Inflammatory Bowel Disease. 2015; 1-1215. View Publication.
    17. M'Koma AE. Mucosal Derived Proteomic Patterns Predict Indeterminate into Ulcerative and Crohn’s Colitides. 3rd International Conference on Predictive, Preventive and Personalized Medicine & Molecular Diagnostics. 2015. View Publication.
    18. Vaiopoulou A, Gazouli M, Papadopoulou A, Anagnostopoulos AK, Karamanolis G, Theodoropoulos GE, M'Koma A, Tsangaris GT. Serum protein profiling of adults and children with Crohn disease. J Pediatr Gastroenterol Nutr. 2015 Jan; 60(1):42-7. PMID: 25250685.
      Citations: 5     Fields:    Translation:Humans
    19. M'Koma AE. Diagnosis of inflammatory bowel disease: Potential role of molecular biometrics. World J Gastrointest Surg. 2014 Nov 27; 6(11):208-19. PMID: 25429322.
      Citations:    
    20. M'Koma AE. Diagnosis of inflammatory bowel disease: Potential role of molecular biometrics. World J Gastrointest Surg. 2014; 6(11):208-219. View Publication.
    21. Myers JN, Schäffer MW, Korolkova OY, Williams AD, Gangula PR, M'Koma AE. Implications of the colonic deposition of free hemoglobin-a chain: a previously unknown tissue by-product in inflammatory bowel disease. Inflamm Bowel Dis. 2014 Sep; 20(9):1530-47. PMID: 25078150.
      Citations: 5     Fields:    Translation:Humans
    22. M'Koma AE, Moses HL, Adunyah SE. Inflammatory bowel disease-associated colorectal cancer: proctocolectomy and mucosectomy do not necessarily eliminate pouch-related cancer incidences. Int J Colorectal Dis. 2014; 5(26):533-552. View Publication.
    23. M'Koma AE. Inflammatory Bowel Disease: An Expanding Global Health Problem. Clin Med Insights. 2013; 6:33-47. View Publication.
    24. M'Koma AE. Inflammatory bowel disease: an expanding global health problem. Clin Med Insights Gastroenterol. 2013; 6:33-47. PMID: 24833941.
      Citations:    
    25. M'Koma AE, Herline AJ, Adunyah SE. Subsequent Adenomas of Ileal Pouch and Anorectal Segment after Prophylactic Surgery for Familial Adenomatous Polyposis. World Journal of Colorectal Surgery. 2013; 3(2):1. View Publication.
    26. Seeley EH, Washington MK, Caprioli RM, M'Koma AE. Proteomic patterns of colonic mucosal tissues delineate Crohn's colitis and ulcerative colitis. Proteomics Clin Appl. 2013; 7-8(7):541-9. View Publication.
    27. Seeley EH, Washington MK, Caprioli RM, M'Koma AE. Proteomic patterns of colonic mucosal tissues delineate Crohn's colitis and ulcerative colitis. Proteomics Clin Appl. 2013 Aug; 7(7-8):541-9. PMID: 23382084.
      Citations: 17     Fields:    Translation:Humans
    28. Smith JC, Schäffer MW, Ballard BR, Smoot DT, Herline AJ, Adunyah SE, M'Koma AE. Adenocarcinomas after Prophylactic Surgery for Familial Adenomatous Polyposis. Journal of Cancer Research. 2013; 4(1):260-270. View Publication.
    29. M'Koma AE, Herline AJ, Adunyah SE. Subsequent Adenomas of Ileal Pouch and Anorectal Segment after Prophylactic Surgery for Familial Adenomatous Polyposis. World J Colorectal Surg. 2013; 3(2). PMID: 24817992.
      Citations:    
    30. M'Koma AE. Letter to Editor. Adv Enzyme Res. 2013; 1(4):77-78. PMID: 25664328.
      Citations:    
    31. Smith JC, Schäffer MW, Ballard BR, Smoot DT, Herline AJ, Adunyah SE, M'Koma AE. Adenocarcinomas After Prophylactic Surgery For Familial Adenomatous Polyposis. J Cancer Ther. 2013; 4(1):260-270. PMID: 23875116.
      Citations:    
    32. Um JW, M'Koma AE. Dysplasie und Adenokarzinome im Ileum-Pouch nach restaurativer Proctokolectomie wegen Colitis ulcerosa. Coloproctology. 2011; 33(5): 273-282. View Publication.
    33. M'Koma AE, Moses HL, Adunyah SE. Inflammatory bowel disease-associated colorectal cancer: proctocolectomy and mucosectomy do not necessarily eliminate pouch-related cancer incidences. Int J Colorectal Dis. 2011 May; 26(5):533-52. PMID: 21311893.
      Citations: 14     Fields:    Translation:HumansPHPublic Health
    34. Um JW, M'Koma AE. Pouch-related dysplasia and adenocarcinoma following restorative proctocolectomy for ulcerative colitis. Tech Coloproctol. 2011 Mar; 15(1):7-16. PMID: 21287223.
      Citations: 6     Fields:    Translation:Humans
    35. M'Koma AE, Seeley EH, Washington MK, Schwartz DA, Muldoon RL, Herline AJ, Wise PE, Caprioli RM. Proteomic profiling of mucosal and submucosal colonic tissues yields protein signatures that differentiate the inflammatory colitides. Inflamm Bowel Dis. 2011 Apr; 17(4):875-83. PMID: 20806340.
      Citations: 29     Fields:    Translation:Humans
    36. M'Koma AE. Biochemical Laboratory Data Following Restorative Proctocolectomy: Observations on Essential Biochemical Data Profile in Connection with Restorative Proctocolectomy in Humans. LAP Lambert Academic Publishing. 2010; 140. View Publication.
    37. M'Koma AE, Wise PE, Seeley EH, Schwartz DA, Washington MK, Muldoon RL, El-Rifai WM, Herline AJ. Gene Expression of Colonic Submucosa Differs Between the Inflammatory Colitides. Annual Congress - The American Society of Colon and Rectal Surgeons. 2010; 117.
    38. M'Koma AE, Wise PE, Seeley EH, Washington MK, Schwartz DA, Muldoon RL, Herline AJ, Caprioli RM. Human Alpha-Defensins are Differentially Expressed Between the Inflammatory Colitides. Gastroenterology. 2010; 138:S-525.
    39. M'Koma AE, Wise PE, Schwartz DA, Muldoon RL, Herline AJ. Prevalence and outcome of anemia after restorative proctocolectomy: a clinical literature review. Dis Colon Rectum. 2009 Apr; 52(4):726-39. PMID: 19404082.
      Citations: 6     Fields:    Translation:Humans
    40. M'Koma AE, Seeley EH, Wise PE, Washington MK, Schwartz DA, Caprioli RM, Muldoon RL, Herline AJ. Proteomic Patterns of Colonic Submucosa Discriminates Inflammatory Colitides. Annual Congress - The American Society of Colon and Rectal Surgeons. 2009; 166.
    41. M'Koma AE, Seeley EH, Wise PE, Washington MK, Schwartz DA, Herline AJ, Muldoon RL, Caprioli RM. Proteomic analysis of colonic submucosa differentiates Crohn's and ulcerative colitis. Annual Congress - Digestive Disease Week. 2009; P600:M1096. View Publication.
    42. Blum DL, Koyama T, M'Koma AE, Iturregui JM, Martinez-Ferrer M, Uwamariya C, Smith JA, Clark PE, Bhowmick NA. Chemokine markers predict biochemical recurrence of prostate cancer following prostatectomy. Clin Cancer Res. 2008 Dec 01; 14(23):7790-7. PMID: 19047106.
      Citations: 18     Fields:    Translation:Humans
    43. M'Koma AE, Wise PE, Muldoon RL, Schwartz DA, Washington MK, Herline AJ. Evolution of the restorative proctocolectomy and its effects on gastrointestinal hormones. Int J Colorectal Dis. 2007 Oct; 22(10):1143-63. PMID: 17576578.
      Citations: 10     Fields:    Translation:Humans
    44. M'Koma AE, Blum DL, Norris JL, Koyama T, Billheimer D, Motley S, Ghiassi M, Ferdowsi N, Bhowmick I, Chang SS, Fowke JH, Caprioli RM, Bhowmick NA. Detection of pre-neoplastic and neoplastic prostate disease by MALDI profiling of urine. Biochem Biophys Res Commun. 2007 Feb 16; 353(3):829-34. PMID: 17194448.
      Citations: 21     Fields:    Translation:Humans
    45. M'Koma AE, Longo WE. Postoperative liver enzyme abnormalities are related to staged restorative proctocolectomy. Int J Colorectal Dis. 2007 Mar; 22(3):283-8. PMID: 16583192.
      Citations: 2     Fields:    Translation:Humans
    46. M'Koma AE. Serum biochemical evaluation of patients with functional pouches ten to 20 years after restorative proctocolectomy. Int J Colorectal Dis. 2006 Oct; 21(7):711-20. PMID: 16437210.
      Citations: 9     Fields:    Translation:Humans
    47. M'Koma AE. Observations on Essential Biochemical Data Profile in Connection with Restorative Proctocolectomy in Humans. 2001. View Publication.
    48. M'Koma AE, Lindquist K, Liljeqvist L. A study of plasma immunoglobulins profile in connection with restorative proctocolectomy. Int J Surg Investig. 2000; 2(2):125-31. PMID: 12678510.
      Citations: 3     Fields:    Translation:Humans
    49. M'Koma AE, Lindquist K, Liljeqvist L. Observations in the blood lipid profile in patients undergoing restorative proctocolectomy. Int J Surg Investig. 2000; 2(3):227-35. PMID: 12678523.
      Citations: 3     Fields:    Translation:Humans
    50. M'Koma AE, Lindquist K, Liljeqvist L. Effect of restorative proctocolectomy on gastric acid secretion and serum gastrin levels: a prospective study. Dis Colon Rectum. 1999 Mar; 42(3):398-402. PMID: 10223764.
      Citations: 4     Fields:    Translation:Humans
    51. Amosy E. M'Koma . Original Resarch. Observations on Biochemical Data in Connection with Restorative Proctocolectomy [An analysis with specific reference to lipoproteins and gastric acids]. 1999; 8(12):e017910. View Publication.
    52. M'Koma AE. Follow-up results of hematology data before and after restorative proctocolectomy. Clinical outcome. Dis Colon Rectum. 1994 Sep; 37(9):932-7. PMID: 8076494.
      Citations: 10     Fields:    Translation:Humans
    53. M'Koma AE, Lindquist K, Liljeqvist L. Biochemical laboratory data in patients before and after restorative proctocolectomy. A study on 83 patients with a follow-up of 36 months. Ann Chir. 1994; 48(6):525-34. PMID: 7847701.
      Citations: 5     Fields:    Translation:Humans
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