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Amos Sakwe

Faculty RankAssistant Professor
InstitutionMeharry Medical College
DepartmentBiochem, Cancer Biology, Neuroscience & Pharmacology
AddressMeharry medical College
Department of Biochem, Cancer Biology, Neuroscience & Pharmacology
1005 Dr. DB Todd Jr. Blvd
Nashville TN 37208
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    Collapse Research 
    Collapse research activities and funding
    SC2CA170244     (SAKWE, AMOS MALLE)Mar 1, 2012 - Feb 29, 2016
    The role of annexin A6 in breast cancer metastasis
    Role: Principal Investigator

    SC1CA211030     (SAKWE, AMOS MALLE)Aug 16, 2016 - Jul 31, 2021
    Role: Principal Investigator

    SC1GM139814     (SAKWE, AMOS MALLE)Sep 1, 2021 - Jul 31, 2025
    Mechanisms of Annexin A6 Mediated Basal-like Breast Cancer Progression
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Davis JS, Sakwe AM, Ramesh A, Lindsey ML, Woods L. How to be a GREAT mentor. Adv Physiol Educ. 2023 Sep 01; 47(3):584-588. PMID: 37345850.
      Citations: 1     Fields:    Translation:Humans
    2. Virgous C, Lyons L, Sakwe A, Nayyar T, Goodwin S, Hildreth J, Osteen K, Bruner-Tran K, Alawode O, Bourne P, Hills ER, Archibong AE. Resumption of Spermatogenesis and Fertility Post Withdrawal of Hydroxyurea Treatment. Int J Mol Sci. 2023 May 27; 24(11). PMID: 37298325.
      Citations: 1     Fields:    Translation:Animals
    3. Williams SD, Smith TM, Stewart LV, Sakwe AM. Hypoxia-Inducible Expression of Annexin A6 Enhances the Resistance of Triple-Negative Breast Cancer Cells to EGFR and AR Antagonists. Cells. 2022 09 27; 11(19). PMID: 36230969.
      Citations: 1     Fields:    Translation:HumansCells
    4. Ochieng J, Korolkova OY, Li G, Jin R, Chen Z, Matusik RJ, Adunyah S, Sakwe AM, Ogunkua O. Fetuin-A Promotes 3-Dimensional Growth in LNCaP Prostate Cancer Cells by Sequestering Extracellular Vesicles to Their Surfaces to Act as Signaling Platforms. Int J Mol Sci. 2022 Apr 05; 23(7). PMID: 35409390.
      Citations: 2     Fields:    Translation:HumansCells
    5. Beasley HK, Widatalla SE, Whalen DS, Williams SD, Korolkova OY, Namba C, Pratap S, Ochieng J, Sakwe AM. Identification of MAGEC2/CT10 as a High Calcium-Inducible Gene in Triple-Negative Breast Cancer. Front Endocrinol (Lausanne). 2022; 13:816598. PMID: 35355564.
      Citations:    Fields:    Translation:HumansCells
    6. Williams SD, Sakwe AM. Reduced Expression of Annexin A6 Induces Metabolic Reprogramming That Favors Rapid Fatty Acid Oxidation in Triple-Negative Breast Cancer Cells. Cancers (Basel). 2022 Feb 22; 14(5). PMID: 35267416.
    7. Actkins KV, Beasley HK, Faucon AB, Davis LK, Sakwe AM. Calcium-Sensing Receptor Polymorphisms at rs1801725 Are Associated with Increased Risk of Secondary Malignancies. J Pers Med. 2021 Jul 06; 11(7). PMID: 34357109.
    8. Rana T, Korolkova OY, Rachakonda G, Williams AD, Hawkins AT, James SD, Sakwe AM, Hui N, Wang L, Yu C, Goodwin JS, Izban MG, Offodile RS, Washington MK, Ballard BR, Smoot DT, Shi XZ, Forbes DS, Shanker A, M'Koma AE. Linking bacterial enterotoxins and alpha defensin 5 expansion in the Crohn's colitis: A new insight into the etiopathogenetic and differentiation triggers driving colonic inflammatory bowel disease. PLoS One. 2021; 16(3):e0246393. PMID: 33690604.
      Citations: 9     Fields:    Translation:HumansCells
    9. Thomas PL, Nangami G, Rana T, Evans A, Williams SD, Crowell D, Shanker A, Sakwe AM, Ochieng J. The rapid endocytic uptake of fetuin-A by adherent tumor cells is mediated by Toll-like receptor 4 (TLR4). FEBS Open Bio. 2020 12; 10(12):2722-2732. PMID: 33073533.
      Citations:    Fields:    Translation:HumansCells
    10. Korolkova OY, Widatalla SE, Williams SD, Whalen DS, Beasley HK, Ochieng J, Grewal T, Sakwe AM. Diverse Roles of Annexin A6 in Triple-Negative Breast Cancer Diagnosis, Prognosis and EGFR-Targeted Therapies. Cells. 2020 08 07; 9(8). PMID: 32784650.
      Citations: 14     Fields:    Translation:HumansCells
    11. Korolkova OY, Widatalla SE, Whalen DS, Nangami GN, Abimbola A, Williams SD, Beasley HK, Reisenbichler E, Washington MK, Ochieng J, Mayer IA, Lehmann BD, Sakwe AM. Reciprocal expression of Annexin A6 and RasGRF2 discriminates rapidly growing from invasive triple negative breast cancer subsets. PLoS One. 2020; 15(4):e0231711. PMID: 32298357.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    12. Widatalla SE, Korolkova OY, Whalen DS, Goodwin JS, Williams KP, Ochieng J, Sakwe AM. Lapatinib-induced annexin A6 upregulation as an adaptive response of triple-negative breast cancer cells to EGFR tyrosine kinase inhibitors. Carcinogenesis. 2019 08 22; 40(8):998-1009. PMID: 30590459.
      Citations: 16     Fields:    Translation:HumansCells
    13. Whalen DS, Widatalla SE, Korolkova OY, Nangami GS, Beasley HK, Williams SD, Virgous C, Lehmann BD, Ochieng J, Sakwe AM. Implication of calcium activated RasGRF2 in Annexin A6-mediated breast tumor cell growth and motility. Oncotarget. 2019 Jan 04; 10(2):133-151. PMID: 30719209.
      Citations: 9     Fields:    
    14. Ochieng J, Nangami G, Sakwe A, Rana T, Ingram S, Goodwin JS, Moye C, Lammers P, Adunyah SE. Extracellular histones are the ligands for the uptake of exosomes and hydroxyapatite-nanoparticles by tumor cells via syndecan-4. FEBS Lett. 2018 10; 592(19):3274-3285. PMID: 30179249.
      Citations: 16     Fields:    Translation:HumansCells
    15. Ochieng J, Nangami G, Sakwe A, Moye C, Alvarez J, Whalen D, Thomas P, Lammers P. Impact of Fetuin-A (AHSG) on Tumor Progression and Type 2 Diabetes. Int J Mol Sci. 2018 Jul 29; 19(8). PMID: 30060600.
      Citations: 22     Fields:    Translation:HumansAnimals
    16. Burroughs AF, Eluhu S, Whalen D, Goodwin JS, Sakwe AM, Arinze IJ. PML-Nuclear Bodies Regulate the Stability of the Fusion Protein Dendra2-Nrf2 in the Nucleus. Cell Physiol Biochem. 2018; 47(2):800-816. PMID: 29807365.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    17. Williams AD, Korolkova OY, Sakwe AM, Geiger TM, James SD, Muldoon RL, Herline AJ, Goodwin JS, Izban MG, Washington MK, Smoot DT, Ballard BR, Gazouli M, M'Koma AE. Correction: Human alpha defensin 5 is a candidate biomarker to delineate inflammatory bowel disease. PLoS One. 2017; 12(12):e0189551. PMID: 29211779.
      Citations:    Fields:    
    18. Williams AD, Korolkova OY, Sakwe AM, Geiger TM, James SD, Muldoon RL, Herline AJ, Goodwin JS, Izban MG, Washington MK, Smoot DT, Ballard BR, Gazouli M, M'Koma AE. Human alpha defensin 5 is a candidate biomarker to delineate inflammatory bowel disease. PLoS One. 2017; 12(8):e0179710. PMID: 28817680.
      Citations: 19     Fields:    Translation:Humans
    19. Wang L, Widatalla SE, Whalen DS, Ochieng J, Sakwe AM. Association of calcium sensing receptor polymorphisms at rs1801725 with circulating calcium in breast cancer patients. BMC Cancer. 2017 Aug 02; 17(1):511. PMID: 28764683.
      Citations: 10     Fields:    Translation:Humans
    20. Nangami GN, Sakwe AM, Izban MG, Rana T, Lammers PE, Thomas P, Chen Z, Ochieng J. Fetuin-A (alpha 2HS glycoprotein) modulates growth, motility, invasion, and senescence in high-grade astrocytomas. Cancer Med. 2016 12; 5(12):3532-3543. PMID: 27882696.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    21. Nangami G, Koumangoye R, Shawn Goodwin J, Sakwe AM, Marshall D, Higginbotham J, Ochieng J. Fetuin-A associates with histones intracellularly and shuttles them to exosomes to promote focal adhesion assembly resulting in rapid adhesion and spreading in breast carcinoma cells. Exp Cell Res. 2014 Nov 01; 328(2):388-400. PMID: 25194507.
      Citations: 22     Fields:    Translation:HumansCells
    22. Koumangoye RB, Nangami GN, Thompson PD, Agboto VK, Ochieng J, Sakwe AM. Reduced annexin A6 expression promotes the degradation of activated epidermal growth factor receptor and sensitizes invasive breast cancer cells to EGFR-targeted tyrosine kinase inhibitors. Mol Cancer. 2013 Dec 19; 12(1):167. PMID: 24354805.
      Citations: 30     Fields:    Translation:HumansCells
    23. Thompson PD, Sakwe A, Koumangoye R, Yarbrough WG, Ochieng J, Marshall DR. Alpha-2 Heremans Schmid Glycoprotein (AHSG) modulates signaling pathways in head and neck squamous cell carcinoma cell line SQ20B. Exp Cell Res. 2014 Feb 15; 321(2):123-32. PMID: 24332981.
      Citations: 11     Fields:    Translation:HumansCells
    24. Nangami GN, Watson K, Parker-Johnson K, Okereke KO, Sakwe A, Thompson P, Frimpong N, Ochieng J. Fetuin-A (a2HS-glycoprotein) is a serum chemo-attractant that also promotes invasion of tumor cells through Matrigel. Biochem Biophys Res Commun. 2013 Sep 06; 438(4):660-5. PMID: 23933250.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    25. Watson K, Koumangoye R, Thompson P, Sakwe AM, Patel T, Pratap S, Ochieng J. Fetuin-A triggers the secretion of a novel set of exosomes in detached tumor cells that mediate their adhesion and spreading. FEBS Lett. 2012 Sep 21; 586(19):3458-63. PMID: 22980907.
      Citations: 21     Fields:    Translation:HumansCells
    26. Jagannathan M, Sakwe AM, Nguyen T, Frappier L. The MCM-associated protein MCM-BP is important for human nuclear morphology. J Cell Sci. 2012 Jan 01; 125(Pt 1):133-43. PMID: 22250201.
      Citations: 16     Fields:    Translation:HumansCells
    27. Koumangoye RB, Sakwe AM, Goodwin JS, Patel T, Ochieng J. Detachment of breast tumor cells induces rapid secretion of exosomes which subsequently mediate cellular adhesion and spreading. PLoS One. 2011; 6(9):e24234. PMID: 21915303.
      Citations: 106     Fields:    Translation:HumansCells
    28. Sakwe AM, Koumangoye R, Guillory B, Ochieng J. Annexin A6 contributes to the invasiveness of breast carcinoma cells by influencing the organization and localization of functional focal adhesions. Exp Cell Res. 2011 Apr 01; 317(6):823-37. PMID: 21185831.
      Citations: 41     Fields:    Translation:HumansCells
    29. Sakwe AM, Koumangoye R, Goodwin SJ, Ochieng J. Fetuin-A ({alpha}2HS-glycoprotein) is a major serum adhesive protein that mediates growth signaling in breast tumor cells. J Biol Chem. 2010 Dec 31; 285(53):41827-35. PMID: 20956534.
      Citations: 31     Fields:    Translation:HumansCells
    30. Guillory B, Sakwe AM, Saria M, Thompson P, Adhiambo C, Koumangoye R, Ballard B, Binhazim A, Cone C, Jahanen-Dechent W, Ochieng J. Lack of fetuin-A (alpha2-HS-glycoprotein) reduces mammary tumor incidence and prolongs tumor latency via the transforming growth factor-beta signaling pathway in a mouse model of breast cancer. Am J Pathol. 2010 Nov; 177(5):2635-44. PMID: 20847285.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    31. Ochieng J, Pratap S, Khatua AK, Sakwe AM. Anchorage-independent growth of breast carcinoma cells is mediated by serum exosomes. Exp Cell Res. 2009 Jul 01; 315(11):1875-88. PMID: 19327352.
      Citations: 44     Fields:    Translation:HumansCells
    32. Aguda AH, Sakwe AM, Rask L, Robinson RC. Expression, crystallization and preliminary crystallographic data analysis of filamin A repeats 14-16. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Apr 01; 63(Pt 4):291-3. PMID: 17401197.
      Citations:    Fields:    Translation:HumansCells
    33. Sakwe AM, Nguyen T, Athanasopoulos V, Shire K, Frappier L. Identification and characterization of a novel component of the human minichromosome maintenance complex. Mol Cell Biol. 2007 Apr; 27(8):3044-55. PMID: 17296731.
      Citations: 33     Fields:    Translation:HumansCells
    34. Sakwe AM, Rask L, Gylfe E. Protein kinase C modulates agonist-sensitive release of Ca2+ from internal stores in HEK293 cells overexpressing the calcium sensing receptor. J Biol Chem. 2005 Feb 11; 280(6):4436-41. PMID: 15572354.
      Citations: 7     Fields:    Translation:HumansCells
    35. Sakwe AM, Larsson M, Rask L. Involvement of protein kinase C-alpha and -epsilon in extracellular Ca(2+) signalling mediated by the calcium sensing receptor. Exp Cell Res. 2004 Jul 15; 297(2):560-73. PMID: 15212956.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    36. Larsson M, Hj?lm G, Sakwe AM, Engstr?m A, H?glund AS, Larsson E, Robinson RC, Sundberg C, Rask L. Selective interaction of megalin with postsynaptic density-95 (PSD-95)-like membrane-associated guanylate kinase (MAGUK) proteins. Biochem J. 2003 Jul 15; 373(Pt 2):381-91. PMID: 12713445.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    37. Sakwe AM, Engstr?m A, Larsson M, Rask L. Biosynthesis and secretion of parathyroid hormone are sensitive to proteasome inhibitors in dispersed bovine parathyroid cells. J Biol Chem. 2002 May 17; 277(20):17687-95. PMID: 11884387.
      Citations: 2     Fields:    Translation:AnimalsCells
    38. Sakwe AM, Evehe MS, Titanji VP. In vitro production and characterization of excretory/secretory products of Onchocerca volvulus. Parasite. 1997 Dec; 4(4):351-8. PMID: 9587603.
      Citations: 3     Fields:    Translation:Animals
    39. Sakwe AM, Titanji VP. Evidence for increased hydroxylation of pyrrolidone amino acid residues in the cuticle of mature Onchocerca volvulus. Biochim Biophys Acta. 1997 May 24; 1360(3):196-202. PMID: 9197461.
      Citations:    Fields:    Translation:AnimalsCells
    40. Titanji VP, Mbacham WF, Sakwe A. Identification of different radiolabelled antigens of the developmental stages of Onchocerca volvulus. Acta Trop. 1990 Jul; 47(5-6):307-21. PMID: 1978531.
      Citations:    Fields:    Translation:HumansAnimals
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