RCMI Coordinating Center (RCMI CC) Header Logo

Sanika Chirwa

Faculty RankProfessor
InstitutionMeharry Medical College
DepartmentBiochem, Cancer Biology, Neuroscience & Pharmacology
AddressBiochemistry, Cancer Biology, Biochem, Cancer Biology, Neuroscience & Pharmacology
Meharry Medical College
1005 D. B. Todd Jr. Boulevard
Nashville TN 37208
vCardDownload vCard
    Other Positions
    TitleAdjunct Professor
    InstitutionVanderbilt University

    Collapse Overview 
    Collapse overview
    Dr. Sanika S. Chirwa is a tenured professor of neuroscience and pharmacology at Meharry Medical College and adjunct professor of pharmacology at Vanderbilt University. He has a strong background in pharmacy, medicine, and biomedical science obtained from the Faculty of Pharmaceutical Sciences and Faculty of Medicine at the University of British Columbia in Canada between 1976 and 1988. As a postdoctoral scholar between 1989 and 1992 at the Brain Research Institute of the University of California Los Angeles, he trained in sleep physiology. Presently, Dr. Chirwa is heavily engaged in the training of professional and research students at all levels of their development. He is also an active investigator and his research projects comprises both basic science and clinical research as follows. The basic research is focusing on understanding the neural networks and synaptic plasticity mechanisms responsible for memory encoding and recall in the brain, and how these neural functions are altered by drugs of abuse – e.g. methamphetamine. New project is focusing on determining in the guinea pig model the mechanisms and long-term consequences of prenatal exposure to methamphetamine on neurocognitive functions and behaviors in offspring across the life span. The clinical studies are investigating causal links between sleep deprivation and several clinical complications including adverse pregnancy outcomes (e.g. gestational diabetes, preeclampsia, preterm and hemorrhage), epilepsy, and Alzheimer’s disease. New studies in development include spearheading the development of a novel high-throughput multidrug mass spectrometry assay to simultaneously quantify multiple drugs widely prescribed to HIV-infected adults. This platform will be used to evaluate and discover how unexpected but clinically significant drug-drug interactions affect many HIV-infected patients as a consequence of polypharmacy for HIV and comorbidities.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. M'Koma AE, Ware JN, Nabaweesi RK, Chirwa SS. Managing Pregnancy and Nursing Affecting African American Women with Inflammatory Bowel Disease: Clinical Outcomes and Parenthood. Med Res Arch. 2023 Jun; 11(6). PMID: 37492395.
    2. Uzhachenko R, Shimamoto A, Chirwa SS, Ivanov SV, Ivanova AV, Shanker A. Mitochondrial Fus1/Tusc2 and cellular Ca2+ homeostasis: tumor suppressor, anti-inflammatory and anti-aging implications. Cancer Gene Ther. 2022 10; 29(10):1307-1320. PMID: 35181743.
      Citations: 3     Fields:    Translation:Humans
    3. Desta Z, Gammal RS, Gong L, Whirl-Carrillo M, Gaur AH, Sukasem C, Hockings J, Myers A, Swart M, Tyndale RF, Masimirembwa C, Iwuchukwu OF, Chirwa S, Lennox J, Gaedigk A, Klein TE, Haas DW. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2B6 and Efavirenz-Containing Antiretroviral Therapy. Clin Pharmacol Ther. 2019 10; 106(4):726-733. PMID: 31006110.
      Citations: 58     Fields:    Translation:HumansCells
    4. Chirwa S, Nwabuisi CR, Ladson GM, Korley L, Whitty JE, Atkinson R, Clark JT. Poor Sleep Quality Is Associated with Higher Hemoglobin A1c in Pregnant Women: A Pilot Observational Study. Int J Environ Res Public Health. 2018 10 18; 15(10). PMID: 30340366.
      Citations: 9     Fields:    Translation:Humans
    5. Leger P, Chirwa S, Nwogu JN, Turner M, Richardson DM, Baker P, Leonard M, Erdem H, Olson L, Haas DW. Race/ethnicity difference in the pharmacogenetics of bilirubin-related atazanavir discontinuation. Pharmacogenet Genomics. 2018 Jan; 28(1):1-6. PMID: 29117017.
      Citations: 3     Fields:    Translation:Humans
    6. Leger P, Chirwa S, Turner M, Richardson DM, Baker P, Leonard M, Erdem H, Olson L, Haas DW. Pharmacogenetics of efavirenz discontinuation for reported central nervous system symptoms appears to differ by race. Pharmacogenet Genomics. 2016 10; 26(10):473-80. PMID: 27509478.
      Citations: 9     Fields:    Translation:Humans
    7. Munkombwe D, Muungo TL, Michelo C, Kelly P, Chirwa S, Filteau S. Lipid-based nutrient supplements containing vitamins and minerals attenuate renal electrolyte loss in HIV/AIDS patients starting antiretroviral therapy: A randomized controlled trial in Zambia. Clin Nutr ESPEN. 2016 06; 13:e8-e14. PMID: 28531643.
      Citations: 4     Fields:    Translation:Humans
    8. Lee KN, Chirwa S. Blocking Dopaminergic Signaling Soon after Learning Impairs Memory Consolidation in Guinea Pigs. PLoS One. 2015; 10(8):e0135578. PMID: 26275140.
      Citations: 4     Fields:    Translation:AnimalsCells
    9. Nyongesa A, Oduma J, al'Absi M, Chirwa S. Immunohistochemical localization of anterior pituitary cell types of vervet monkey (Chlorocebus aethiops) following sub-chronic cathinone exposure. J Ethnopharmacol. 2015 Nov 04; 174:168-77. PMID: 26277490.
      Citations: 2     Fields:    Translation:Animals
    10. Lee KN, Pellom ST, Oliver E, Chirwa S. Characterization of the guinea pig animal model and subsequent comparison of the behavioral effects of selective dopaminergic drugs and methamphetamine. Synapse. 2014 May; 68(5):221-33. PMID: 24436154.
      Citations: 5     Fields:    Translation:Animals
    11. Swant J, Goodwin JS, North A, Ali AA, Gamble-George J, Chirwa S, Khoshbouei H. a-Synuclein stimulates a dopamine transporter-dependent chloride current and modulates the activity of the transporter. J Biol Chem. 2011 Dec 23; 286(51):43933-43943. PMID: 21990355.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    12. Hood DB, Ramesh A, Khoshbouei H, Chirwa S, Archibong A. In: Gupta RC (Editor), Reproductive and Developmental Toxicology. Developmental toxicity of polycyclic aromatic hydrocarbons. 2011.
    13. Swant J, Chirwa S, Stanwood G, Khoshbouei H. Methamphetamine reduces LTP and increases baseline synaptic transmission in the CA1 region of mouse hippocampus. PLoS One. 2010 Jun 30; 5(6):e11382. PMID: 20614033.
      Citations: 37     Fields:    Translation:AnimalsCells
    14. Onaivi ES, Ishiguro H, Gong JP, Patel S, Meozzi PA, Myers L, Perchuk A, Mora Z, Tagliaferro PA, Gardner E, Brusco A, Akinshola BE, Liu QR, Chirwa SS, Hope B, Lujilde J, Inada T, Iwasaki S, Macharia D, Teasenfitz L, Arinami T, Uhl GR. Functional expression of brain neuronal CB2 cannabinoid receptors are involved in the effects of drugs of abuse and in depression. Ann N Y Acad Sci. 2008 Oct; 1139:434-49. PMID: 18991891.
      Citations: 74     Fields:    Translation:HumansAnimals
    15. Williams S, Mmbaga N, Chirwa S. Dopaminergic D1 receptor agonist SKF 38393 induces GAP-43 expression and long-term potentiation in hippocampus in vivo. Neurosci Lett. 2006 Jul 10; 402(1-2):46-50. PMID: 16675111.
      Citations: 9     Fields:    Translation:Animals
    16. Chirwa S, Aduonum A, Pizarro J, Reasor J, Kawai Y, Gonzalez M, McAdory BS, Onaivi E, Barea-Rodriguez EJ. Dopaminergic DA1 signaling couples growth-associated protein-43 and long-term potentiation in guinea pig hippocampus. Brain Res Bull. 2005 Jan 15; 64(5):433-40. PMID: 15607831.
      Citations: 6     Fields:    Translation:Animals
    17. Onaivi ES, Ishiguro H, Zhang PW, Lin Z, Akanshola BE, Leonard CM, Chirwa SS, Uhl GR. In: Onaivi ES. (Editor), Endocannabinoids: The brain and body’s marijuana and beyond. Endocannaboid receptor genetics and marijuana use. 2005; 57-117.
    18. Onaivi ES, Ali SF, Chirwa SS, Zwiller J, Thiriet N, Akinshola BE, Ishiguro H. Ibogaine signals addiction genes and methamphetamine alteration of long-term potentiation. Ann N Y Acad Sci. 2002 Jun; 965:28-46. PMID: 12105083.
      Citations: 9     Fields:    Translation:HumansAnimals
    19. Chirwa S, Mack J, Park R, Dennis K, Aduonum A. An in vivo model for investigating bilateral synaptic plasticity across CA3/CA1 synapses in guinea pig dorsal hippocampus. J Neurosci Methods. 2001 Sep 30; 110(1-2):25-30. PMID: 11564521.
      Citations: 2     Fields:    Translation:AnimalsCells
    20. Chase MH, Engelhardt JK, Adinolfi AM, Chirwa SS. Age-dependent changes in cat masseter nerve: an electrophysiological and morphological study. Brain Res. 1992 Jul 24; 586(2):279-88. PMID: 1521161.
      Citations: 8     Fields:    Translation:AnimalsCells
    21. Morishita W, Xie Z, Chirwa SS, May PB, Sastry BR. Blockade of hippocampal long-term potentiation by saccharin. Neuroscience. 1992; 47(1):21-31. PMID: 1349732.
      Citations:    Fields:    Translation:AnimalsCells
    22. Chirwa SS, Stafford-Segert I, Soja PJ, Chase MH. Strychnine antagonizes jaw-closer motoneuron IPSPs induced by reticular stimulation during active sleep. Brain Res. 1991 May 03; 547(2):323-6. PMID: 1884208.
      Citations: 3     Fields:    Translation:AnimalsCells
    23. Chirwa SS, MacLeod BA, Day B. Intraarticular bupivacaine (Marcaine) after arthroscopic meniscectomy: a randomized double-blind controlled study. Arthroscopy. 1989; 5(1):33-5. PMID: 2650701.
      Citations: 28     Fields:    Translation:HumansCTClinical Trials
    24. Sastry BR, Chirwa SS, May PB, Maretic H. Substances released during tetanic stimulation of rabbit neocortex induce neurite growth in PC-12 cells and long-term potentiation in guinea pig hippocampus. Neurosci Lett. 1988 Aug 15; 91(1):101-5. PMID: 3173780.
      Citations: 1     Fields:    Translation:AnimalsCells
    25. Chirwa SS, Sastry BR. Asynchronous synaptic responses in hippocampal CA1 neurons during synaptic long-term potentiation. Neurosci Lett. 1988 Jul 08; 89(3):355-60. PMID: 3419633.
      Citations: 2     Fields:    Translation:AnimalsCells
    26. Sastry BR, Goh JW, May PB, Chirwa SS. The involvement of nonspiking cells in long-term potentiation of synaptic transmission in the hippocampus. Can J Physiol Pharmacol. 1988 Jun; 66(6):841-4. PMID: 2844374.
      Citations: 4     Fields:    Translation:AnimalsCells
    27. Sastry BR, Chirwa SS, May PBY, Maretic H, Pillai G, Kao EYH , Sidhu SD. In: H. I. Haas, G. Buzsaki. (Ed). Synaptic plasticity in the hippocampus. Are nerve growth factors involved in long-term synaptic potentiation in the hippocampus and spatial memory. 1988; 102-105.
    28. Saint DA, Quastel DM, Chirwa S. Effect of a volatile anesthetic upon presynaptic excitability in mammalian hippocampus. Can J Physiol Pharmacol. 1986 Feb; 64(2):221-3. PMID: 3697837.
      Citations: 2     Fields:    Translation:AnimalsCells
    29. Sastry BR, Chirwa SS, Goh JW, Maretic H, Pandanaboina MM. Verapamil counteracts depression but not long-lasting potentiation of the hippocampal population spike. Life Sci. 1984 Mar 12; 34(11):1075-86. PMID: 6700370.
      Citations: 3     Fields:    Translation:AnimalsCells
    Chirwa's Networks
    Click the
    buttons for more information and interactive visualizations!
    Concepts (181)
    Co-Authors (6)
    Similar People (60)
    Same Department Expand Description
    RCMI CC is supported by the National Institute on Minority Health and Health Disparities, National Institutes of Health (NIH), through Grant Number U24MD015970. The contents of this site are solely the responsibility of the authors and do not necessarily represent the official views of the NIH

    For technical support please contact support