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Rajesh Singh

Faculty RankAssociate Professor
InstitutionMorehouse School of Medicine
DepartmentMicrobiology, Biochemistry, & Immunology
Address720 Westveiw Drive, SW
Atlanta GA 30310
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    SC1CA193758     (SINGH, RAJESH)Sep 1, 2014 - Aug 31, 2021
    Targeted Nanotherapy for prostate cancer
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kinnel B, Singh SK, Oprea-Ilies G, Singh R. Targeted Therapy and Mechanisms of Drug Resistance in Breast Cancer. Cancers (Basel). 2023 Feb 19; 15(4). PMID: 36831661.
    2. Singh SK, Singh R. Nanotherapy: targeting the tumour microenvironment. Nat Rev Cancer. 2022 05; 22(5):258. PMID: 35236941.
      Citations: 2     Fields:    Translation:Humans
    3. Adebayo OO, Dammer EB, Dill CD, Adebayo AO, Oseni SO, Griffen TL, Ohandjo AQ, Yan F, Jain S, Barwick BG, Singh R, Boise LH, Lillard JW. Multivariant Transcriptome Analysis Identifies Modules and Hub Genes Associated with Poor Outcomes in Newly Diagnosed Multiple Myeloma Patients. Cancers (Basel). 2022 Apr 29; 14(9). PMID: 35565356.
    4. Singh SK, Singh R. Cytokines and Chemokines in Cancer Cachexia and Its Long-Term Impact on COVID-19. Cells. 2022 02 08; 11(3). PMID: 35159388.
      Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
    5. Haynes T, Oprea-Ilies G, Manne U, Singh R, Singh S, Mir H. The interplay of pineal hormones and socioeconomic status leading to colorectal cancer disparity. Transl Oncol. 2022 Feb; 16:101330. PMID: 34990909.
    6. Singh SK, Singh R. Surface Plasmon Resonance, a Novel Technique for Sensing Cancer Biomarker: Folate Receptor and Nanoparticles Interface. Methods Mol Biol. 2022; 2413:211-228. PMID: 35044668.
      Citations:    Fields:    Translation:Humans
    7. McFadden M, Singh SK, Oprea-Ilies G, Singh R. Nano-Based Drug Delivery and Targeting to Overcome Drug Resistance of Ovarian Cancers. Cancers (Basel). 2021 Oct 31; 13(21). PMID: 34771642.
    8. Singh SK, Singh S, Singh R. Targeting novel coronavirus SARS-CoV-2 spike protein with phytoconstituents of Momordica charantia. J Ovarian Res. 2021 Sep 27; 14(1):126. PMID: 34579761.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    9. Singh SK, Apata T, Singh S, McFadden M, Singh R. Clinical Implication of Metformin in Relation to Diabetes Mellitus and Ovarian Cancer. Biomedicines. 2021 Aug 16; 9(8). PMID: 34440224.
    10. Mir H, Kapur N, Gales DN, Sharma PK, Oprea-Ilies G, Johnson AT, Singh R, Singh S. CXCR6-CXCL16 Axis Promotes Breast Cancer by Inducing Oncogenic Signaling. Cancers (Basel). 2021 Jul 16; 13(14). PMID: 34298782.
    11. Singh SK, Gordetsky JB, Bae S, Acosta EP, Lillard JW, Singh R. Selective Targeting of the Hedgehog Signaling Pathway by PBM Nanoparticles in Docetaxel-Resistant Prostate Cancer. Cells. 2020 08 27; 9(9). PMID: 32867229.
      Citations: 11     Fields:    Translation:HumansCells
    12. Darling HS, Viswanath S, Singh R, Ranjan S, Pathi N, Rathore A, Pathak A, Sud R. A clinico-epidemiological, pathological, and molecular study of lung cancer in Northwestern India. J Cancer Res Ther. 2020 Jul-Sep; 16(4):771-779. PMID: 32930117.
      Citations: 1     Fields:    Translation:Humans
    13. Singh SK, Mishra MK, Rivers BM, Gordetsky JB, Bae S, Singh R. Biological and Clinical Significance of the CCR5/CCL5 Axis in Hepatocellular Carcinoma. Cancers (Basel). 2020 Apr 05; 12(4). PMID: 32260550.
    14. Noel B, Singh SK, Lillard JW, Singh R. Role of natural compounds in preventing and treating breast cancer. Front Biosci (Schol Ed). 2020 03 01; 12(1):137-160. PMID: 32114452.
      Citations: 10     Fields:    Translation:HumansAnimals
    15. Singh SK, Singh R. Liver cancer incidence and mortality: Disparities based on age, ethnicity, health and nutrition, molecular factors, and geography. Cancer Health Disparities. 2020 Mar; 4:e1-e10. PMID: 34164612.
    16. Anwanwan D, Singh SK, Singh S, Saikam V, Singh R. Challenges in liver cancer and possible treatment approaches. Biochim Biophys Acta Rev Cancer. 2020 01; 1873(1):188314. PMID: 31682895.
      Citations: 257     Fields:    Translation:Humans
    17. Singh SK, Apata T, Gordetsky JB, Singh R. Docetaxel Combined with Thymoquinone Induces Apoptosis in Prostate Cancer Cells via Inhibition of the PI3K/AKT Signaling Pathway. Cancers (Basel). 2019 Sep 18; 11(9). PMID: 31540423.
    18. Singh SK, Mishra MK, Singh R. Hypoxia-inducible factor-1a induces CX3CR1 expression and promotes the epithelial to mesenchymal transition (EMT) in ovarian cancer cells. J Ovarian Res. 2019 May 10; 12(1):42. PMID: 31077234.
      Citations: 17     Fields:    Translation:HumansCells
    19. Singh SK, Lillard JW, Singh R. Reversal of drug resistance by planetary ball milled (PBM) nanoparticle loaded with resveratrol and docetaxel in prostate cancer. Cancer Lett. 2018 07 28; 427:49-62. PMID: 29678549.
      Citations: 28     Fields:    Translation:HumansCells
    20. Singh SK, Mishra MK, Eltoum IA, Bae S, Lillard JW, Singh R. CCR5/CCL5 axis interaction promotes migratory and invasiveness of pancreatic cancer cells. Sci Rep. 2018 01 22; 8(1):1323. PMID: 29358632.
      Citations: 70     Fields:    Translation:HumansCells
    21. Garg SK, Campbell JP, Anugwom C, Wadhwa V, Singh R, Gupta N, Sanaka MR. Incidence and Predictors of Readmissions in Acute Pancreatitis: A Nationwide Analysis. Pancreas. 2018 01; 47(1):46-54. PMID: 29215534.
      Citations: 13     Fields:    Translation:Humans
    22. Singh R, Mishra MK, Aggarwal H. Inflammation, Immunity, and Cancer. Mediators Inflamm. 2017; 2017:6027305. PMID: 29234189.
      Citations: 74     Fields:    Translation:HumansAnimals
    23. Akpalu D, Newman G, Brice M, Powell M, Singh R, Quarshie A, Ofili E, Fonger J, Chronos N, Feldman D. Matrix Signaling Subsequent to a?Myocardial Infarction: A Proteomic Profile of Tissue Factor Microparticles. JACC Basic Transl Sci. 2017 Oct; 2(5):529-542. PMID: 30062169.
    24. Singh SK, Singh S, Lillard JW, Singh R. Drug delivery approaches for breast cancer. Int J Nanomedicine. 2017; 12:6205-6218. PMID: 28883730.
      Citations: 47     Fields:    Translation:Humans
    25. Singh SK, Banerjee S, Acosta EP, Lillard JW, Singh R. Resveratrol induces cell cycle arrest and apoptosis with docetaxel in prostate cancer cells via a p53/ p21WAF1/CIP1 and p27KIP1 pathway. Oncotarget. 2017 Mar 07; 8(10):17216-17228. PMID: 28212547.
      Citations: 78     Fields:    Translation:HumansCells
    26. Banerjee S, Singh SK, Chowdhury I, Lillard JW, Singh R. Combinatorial effect of curcumin with docetaxel modulates apoptotic and cell survival molecules in prostate cancer. Front Biosci (Elite Ed). 2017 03 01; 9(2):235-245. PMID: 28199187.
      Citations: 32     Fields:    Translation:HumansCells
    27. Singh SK, Lillard JW, Singh R. Molecular basis for prostate cancer racial disparities. Front Biosci (Landmark Ed). 2017 01 01; 22(3):428-450. PMID: 27814623.
      Citations: 11     Fields:    Translation:Humans
    28. Singh R, Kapur N, Mir H, Singh N, Lillard JW, Singh S. CXCR6-CXCL16 axis promotes prostate cancer by mediating cytoskeleton rearrangement via Ezrin activation and av?3 integrin clustering. Oncotarget. 2016 Feb 09; 7(6):7343-53. PMID: 26799186.
      Citations: 32     Fields:    Translation:HumansCells
    29. Mir H, Kapur N, Singh R, Sonpavde G, Lillard JW, Singh S. Andrographolide inhibits prostate cancer by targeting cell cycle regulators, CXCR3 and CXCR7 chemokine receptors. Cell Cycle. 2016; 15(6):819-26. PMID: 27029529.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    30. Omosun Y, McKeithen D, Ryans K, Kibakaya C, Blas-Machado U, Li D, Singh R, Inoue K, Xiong ZG, Eko F, Black C, Igietseme J, He Q. Interleukin-10 modulates antigen presentation by dendritic cells through regulation of NLRP3 inflammasome assembly during Chlamydia infection. Infect Immun. 2015 Dec; 83(12):4662-72. PMID: 26371131.
      Citations: 18     Fields:    Translation:AnimalsCells
    31. Mir H, Singh R, Kloecker GH, Lillard JW, Singh S. CXCR6 expression in non-small cell lung carcinoma supports metastatic process via modulating metalloproteinases. Oncotarget. 2015 Apr 30; 6(12):9985-98. PMID: 25888629.
      Citations: 16     Fields:    Translation:HumansCells
    32. Batra M, Sharma R, Chandra V, Aggarwal M, Agarwal U, Gupta P, Singh RP, Tomar S. In silico and proteomic analysis of protein methyltransferase CheR from Bacillus subtilis. Int J Biol Macromol. 2015; 77:168-80. PMID: 25799883.
      Citations: 1     Fields:    Translation:Cells
    33. Gupta P, Sharma PK, Mir H, Singh R, Singh N, Kloecker GH, Lillard JW, Singh S. CCR9/CCL25 expression in non-small cell lung cancer correlates with aggressive disease and mediates key steps of metastasis. Oncotarget. 2014 Oct 30; 5(20):10170-9. PMID: 25296976.
      Citations: 28     Fields:    Translation:HumansCells
    34. Singh R, Gupta P, Kloecker GH, Singh S, Lillard JW. Expression and clinical significance of CXCR5/CXCL13 in human non-small cell lung carcinoma. Int J Oncol. 2014 Dec; 45(6):2232-40. PMID: 25271023.
      Citations: 40     Fields:    Translation:HumansCells
    35. Singh R, Gupta P, Sharma PK, Ades EW, Hollingshead SK, Singh S, Lillard JW. Prediction and characterization of helper T-cell epitopes from pneumococcal surface adhesin A. Immunology. 2014 Apr; 141(4):514-30. PMID: 24138116.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    36. El-Haibi CP, Sharma P, Singh R, Gupta P, Taub DD, Singh S, Lillard JW. Differential G protein subunit expression by prostate cancer cells and their interaction with CXCR5. Mol Cancer. 2013 Jun 18; 12:64. PMID: 23773523.
      Citations: 26     Fields:    Translation:HumansCells
    37. Akama T, Virtucio C, Dong C, Kimura R, Zhang YK, Nieman JA, Sharma R, Lu X, Sales M, Singh R, Wu A, Fan XQ, Liu L, Plattner JJ, Jarnagin K, Freund YR. Structure-activity relationships of 6-(aminomethylphenoxy)-benzoxaborole derivatives as anti-inflammatory agent. Bioorg Med Chem Lett. 2013 Mar 15; 23(6):1680-3. PMID: 23411072.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    38. Hernandez V, Cr?pin T, Palencia A, Cusack S, Akama T, Baker SJ, Bu W, Feng L, Freund YR, Liu L, Meewan M, Mohan M, Mao W, Rock FL, Sexton H, Sheoran A, Zhang Y, Zhang YK, Zhou Y, Nieman JA, Anugula MR, Keramane el M, Savariraj K, Reddy DS, Sharma R, Subedi R, Singh R, O'Leary A, Simon NL, De Marsh PL, Mushtaq S, Warner M, Livermore DM, Alley MR, Plattner JJ. Discovery of a novel class of boron-based antibacterials with activity against gram-negative bacteria. Antimicrob Agents Chemother. 2013 Mar; 57(3):1394-403. PMID: 23295920.
      Citations: 70     Fields:    Translation:HumansAnimalsCells
    39. Freund YR, Akama T, Alley MR, Antunes J, Dong C, Jarnagin K, Kimura R, Nieman JA, Maples KR, Plattner JJ, Rock F, Sharma R, Singh R, Sanders V, Zhou Y. Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center. FEBS Lett. 2012 Sep 21; 586(19):3410-4. PMID: 22841723.
      Citations: 22     Fields:    Translation:HumansCells
    40. Borgegard T, Jur?us A, Olsson F, Rosqvist S, Sabirsh A, Rotticci D, Paulsen K, Klintenberg R, Yan H, Waldman M, Stromberg K, Nord J, Johansson J, Regner A, Parpal S, Malinowsky D, Radesater AC, Li T, Singh R, Eriksson H, Lundkvist J. First and second generation ?-secretase modulators (GSMs) modulate amyloid-? (A?) peptide production through different mechanisms. J Biol Chem. 2012 Apr 06; 287(15):11810-9. PMID: 22334705.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    41. El-Haibi CP, Singh R, Gupta P, Sharma PK, Greenleaf KN, Singh S, Lillard JW. Antibody Microarray Analysis of Signaling Networks Regulated by Cxcl13 and Cxcr5 in Prostate Cancer. J Proteomics Bioinform. 2012; 5(8):177-184. PMID: 24009409.
    42. Singh R, Singh S, Briles DE, Taub DD, Hollingshead SK, Lillard JW. CCL5-independent helper T lymphocyte responses to immuno-dominant pneumococcal surface protein A epitopes. Vaccine. 2012 Feb 01; 30(6):1181-90. PMID: 22178100.
      Citations: 1     Fields:    Translation:AnimalsCells
    43. Moktar A, Singh R, Vadhanam MV, Ravoori S, Lillard JW, Gairola CG, Gupta RC. Cigarette smoke condensate-induced oxidative DNA damage and its removal in human cervical cancer cells. Int J Oncol. 2011 Oct; 39(4):941-7. PMID: 21720711.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    44. El-Haibi CP, Singh R, Sharma PK, Singh S, Lillard JW. CXCL13 mediates prostate cancer cell proliferation through JNK signalling and invasion through ERK activation. Cell Prolif. 2011 Aug; 44(4):311-9. PMID: 21645150.
      Citations: 41     Fields:    Translation:HumansCells
    45. Singh R, Lillard JW, Singh S. Chemokines: key players in cancer progression and metastasis. Front Biosci (Schol Ed). 2011 06 01; 3(4):1569-82. PMID: 21622291.
      Citations: 32     Fields:    Translation:Humans
    46. Singh R, Stockard CR, Grizzle WE, Lillard JW, Singh S. Expression and histopathological correlation of CCR9 and CCL25 in ovarian cancer. Int J Oncol. 2011 Aug; 39(2):373-81. PMID: 21637913.
      Citations: 29     Fields:    Translation:HumansCells
    47. Shankar E, Vykhovanets EV, Vykhovanets OV, Maclennan GT, Singh R, Bhaskaran N, Shukla S, Gupta S. High-fat diet activates pro-inflammatory response in the prostate through association of Stat-3 and NF-?B. Prostate. 2012 Feb; 72(3):233-43. PMID: 21604287.
      Citations: 31     Fields:    Translation:AnimalsCells
    48. Johnson-Holiday C, Singh R, Johnson EL, Grizzle WE, Lillard JW, Singh S. CCR9-CCL25 interactions promote cisplatin resistance in breast cancer cell through Akt activation in a PI3K-dependent and FAK-independent fashion. World J Surg Oncol. 2011 May 03; 9:46. PMID: 21539750.
      Citations: 25     Fields:    Translation:HumansCells
    49. Johnson-Holiday C, Singh R, Johnson E, Singh S, Stockard CR, Grizzle WE, Lillard JW. CCL25 mediates migration, invasion and matrix metalloproteinase expression by breast cancer cells in a CCR9-dependent fashion. Int J Oncol. 2011 May; 38(5):1279-85. PMID: 21344163.
      Citations: 44     Fields:    Translation:HumansCells
    50. Johnson EL, Singh R, Singh S, Johnson-Holiday CM, Grizzle WE, Partridge EE, Lillard JW. CCL25-CCR9 interaction modulates ovarian cancer cell migration, metalloproteinase expression, and invasion. World J Surg Oncol. 2010 Jul 22; 8:62. PMID: 20649989.
      Citations: 22     Fields:    Translation:HumansCells
    51. Johnson EL, Singh R, Johnson-Holiday CM, Grizzle WE, Partridge EE, Lillard JW, Singh S. CCR9 interactions support ovarian cancer cell survival and resistance to cisplatin-induced apoptosis in a PI3K-dependent and FAK-independent fashion. J Ovarian Res. 2010 Jun 17; 3:15. PMID: 20565782.
      Citations: 20     Fields:    
    52. El Haibi CP, Sharma PK, Singh R, Johnson PR, Suttles J, Singh S, Lillard JW. PI3Kp110-, Src-, FAK-dependent and DOCK2-independent migration and invasion of CXCL13-stimulated prostate cancer cells. Mol Cancer. 2010 Apr 22; 9:85. PMID: 20412587.
      Citations: 30     Fields:    Translation:HumansCells
    53. VanCleave TT, Moore JH, Benford ML, Brock GN, Kalbfleisch T, Baumgartner RN, Lillard JW, Kittles RA, Kidd LC. Interaction among variant vascular endothelial growth factor (VEGF) and its receptor in relation to prostate cancer risk. Prostate. 2010 Mar 01; 70(4):341-52. PMID: 19908237.
      Citations: 25     Fields:    Translation:Humans
    54. Singh R, Singh S, Sharma PK, Singh UP, Briles DE, Hollingshead SK, Lillard JW. Helper T cell epitope-mapping reveals MHC-peptide binding affinities that correlate with T helper cell responses to pneumococcal surface protein A. PLoS One. 2010 Feb 25; 5(2):e9432. PMID: 20195541.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    55. Singh S, Singh R, Singh UP, Rai SN, Novakovic KR, Chung LW, Didier PJ, Grizzle WE, Lillard JW. Clinical and biological significance of CXCR5 expressed by prostate cancer specimens and cell lines. Int J Cancer. 2009 Nov 15; 125(10):2288-95. PMID: 19610059.
      Citations: 40     Fields:    Translation:HumansCells
    56. Singh S, Singh R, Sharma PK, Singh UP, Rai SN, Chung LW, Cooper CR, Novakovic KR, Grizzle WE, Lillard JW. Serum CXCL13 positively correlates with prostatic disease, prostate-specific antigen and mediates prostate cancer cell invasion, integrin clustering and cell adhesion. Cancer Lett. 2009 Sep 28; 283(1):29-35. PMID: 19375853.
      Citations: 47     Fields:    Translation:HumansCells
    57. Singh R, Lillard JW. Nanoparticle-based targeted drug delivery. Exp Mol Pathol. 2009 Jun; 86(3):215-23. PMID: 19186176.
      Citations: 466     Fields:    Translation:HumansAnimals
    58. Singh R, Singh S, Lillard JW. Past, present, and future technologies for oral delivery of therapeutic proteins. J Pharm Sci. 2008 Jul; 97(7):2497-523. PMID: 17918721.
      Citations: 28     Fields:    Translation:Cells
    59. Singh UP, Singh R, Singh S, Karls RK, Quinn FD, Taub DD, Lillard JW. CXCL10+ T cells and NK cells assist in the recruitment and activation of CXCR3+ and CXCL11+ leukocytes during Mycobacteria-enhanced colitis. BMC Immunol. 2008 Jun 04; 9:25. PMID: 18533024.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    60. Singh UP, Singh S, Singh R, Cong Y, Taub DD, Lillard JW. CXCL10-producing mucosal CD4+ T cells, NK cells, and NKT cells are associated with chronic colitis in IL-10(-/-) mice, which can be abrogated by anti-CXCL10 antibody inhibition. J Interferon Cytokine Res. 2008 Jan; 28(1):31-43. PMID: 18370870.
      Citations: 31     Fields:    Translation:AnimalsCells
    61. Zuba-Surma EK, Kucia M, Abdel-Latif A, Dawn B, Hall B, Singh R, Lillard JW, Ratajczak MZ. Morphological characterization of very small embryonic-like stem cells (VSELs) by ImageStream system analysis. J Cell Mol Med. 2008 Jan-Feb; 12(1):292-303. PMID: 18031297.
      Citations: 49     Fields:    Translation:AnimalsCells
    62. Singh UP, Venkataraman C, Singh R, Lillard JW. CXCR3 axis: role in inflammatory bowel disease and its therapeutic implication. Endocr Metab Immune Disord Drug Targets. 2007 Jun; 7(2):111-23. PMID: 17584151.
      Citations: 48     Fields:    Translation:HumansAnimals
    63. Singh UP, Singh S, Singh R, Karls RK, Quinn FD, Potter ME, Lillard JW. Influence of Mycobacterium avium subsp. paratuberculosis on colitis development and specific immune responses during disease. Infect Immun. 2007 Aug; 75(8):3722-8. PMID: 17502388.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    64. Palaniappan R, Singh S, Singh UP, Singh R, Ades EW, Briles DE, Hollingshead SK, Royal W, Sampson JS, Stiles JK, Taub DD, Lillard JW. CCL5 modulates pneumococcal immunity and carriage. J Immunol. 2006 Feb 15; 176(4):2346-56. PMID: 16455992.
      Citations: 20     Fields:    Translation:AnimalsCells
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