RCMI Coordinating Center (RCMI CC) Header Logo

Shailesh Singh

Title
Faculty RankProfessor
InstitutionMorehouse School of Medicine
DepartmentMicrobiology, Biochemistry, & Immunology
Address720 Westveiw Drive, SW
Hugh Gloster building
Atlanta GA 30310
Phone4047565784
vCardDownload vCard

    Collapse Research 
    Collapse research activities and funding
    R21CA169716     (SINGH, SHAILESH)Apr 1, 2013 - Mar 31, 2015
    NIH/NCI
    Prostate Cancer Chemoprevention using a Natural Agent
    Role: Principal Investigator

    SC1CA180212     (SINGH, SHAILESH)Apr 1, 2013 - Mar 31, 2018
    NIH/NCI
    Role of CCL25-CCR9 in Prostate Cancer
    Role: Principal Investigator

    U01CA179701     (SINGH, SHAILESH)Sep 1, 2013 - Aug 30, 2018
    NIH/NCI
    Role of chemokine receptor in disparities associated with prostate cancer progres
    Role: Principal Investigator

    R41MD010320     (SINGH, SHAILESH)Aug 1, 2015 - Jul 31, 2016
    NIH/NIMHD
    Anti-CXCL13 mAb to mitigate prostate cancer health disparities
    Role: Principal Investigator

    R41CA214080     (SINGH, SHAILESH)Jan 1, 2017 - Dec 31, 2017
    NIH/NCI
    Anti-CCL25 mAb to treat castration resistant prostate cancer
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. King Thomas J, Mir H, Kapur N, Singh S. Racial Differences in Immunological Landscape Modifiers Contributing to Disparity in Prostate Cancer. Cancers (Basel). 2019 Nov 25; 11(12). PMID: 31769418.
      Citations:    
    2. Saunders IT, Mir H, Kapur N, Singh S. Emodin inhibits colon cancer by altering BCL-2 family proteins and cell survival pathways. Cancer Cell Int. 2019; 19:98. PMID: 31011292.
      Citations:    
    3. Kapur N, Mir H, Sonpavde GP, Jain S, Bae S, Lillard JW, Singh S. Prostate cancer cells hyper-activate CXCR6 signaling by cleaving CXCL16 to overcome effect of docetaxel. Cancer Lett. 2019 07 10; 454:1-13. PMID: 30974114.
      Citations: 1     Fields:    Translation:HumansCells
    4. Thomas JK, Mir H, Kapur N, Bae S, Singh S. CC chemokines are differentially expressed in Breast Cancer and are associated with disparity in overall survival. Sci Rep. 2019 03 08; 9(1):4014. PMID: 30850664.
      Citations: 7     Fields:    Translation:Humans
    5. Mir H, Kaur G, Kapur N, Bae S, Lillard JW, Singh S. Higher CXCL16 exodomain is associated with aggressive ovarian cancer and promotes the disease by CXCR6 activation and MMP modulation. Sci Rep. 2019 02 21; 9(1):2527. PMID: 30792527.
      Citations: 2     Fields:    Translation:HumansCells
    6. Carriere PP, Kapur N, Mir H, Ward AB, Singh S. Cinnamtannin B-1 inhibits cell survival molecules and induces apoptosis in colon cancer. Int J Oncol. 2018 Oct; 53(4):1442-1454. PMID: 30066888.
      Citations: 1     Fields:    Translation:HumansCells
    7. Ward AB, Mir H, Kapur N, Gales DN, Carriere PP, Singh S. Quercetin inhibits prostate cancer by attenuating cell survival and inhibiting anti-apoptotic pathways. World J Surg Oncol. 2018 Jun 14; 16(1):108. PMID: 29898731.
      Citations: 13     Fields:    Translation:HumansCells
    8. King J, Mir H, Singh S. Association of Cytokines and Chemokines in Pathogenesis of Breast Cancer. Prog Mol Biol Transl Sci. 2017; 151:113-136. PMID: 29096891.
      Citations: 6     Fields:    Translation:Humans
    9. Kapur N, Mir H, Clark Iii CE, Krishnamurti U, Beech DJ, Lillard JW, Singh S. CCR6 expression in colon cancer is associated with advanced disease and supports epithelial-to-mesenchymal transition. Br J Cancer. 2016 06 14; 114(12):1343-51. PMID: 27149649.
      Citations: 12     Fields:    Translation:HumansCells
    10. Singh R, Kapur N, Mir H, Singh N, Lillard JW, Singh S. CXCR6-CXCL16 axis promotes prostate cancer by mediating cytoskeleton rearrangement via Ezrin activation and avß3 integrin clustering. Oncotarget. 2016 Feb 09; 7(6):7343-53. PMID: 26799186.
      Citations: 20     Fields:    Translation:HumansCells
    11. Mir H, Kapur N, Singh R, Sonpavde G, Lillard JW, Singh S. Andrographolide inhibits prostate cancer by targeting cell cycle regulators, CXCR3 and CXCR7 chemokine receptors. . 2016; 15(6):819-26. PMID: 27029529.
      Citations:    
    12. Dickinson-Copeland CM, Wilson NO, Liu M, Driss A, Salifu H, Adjei AA, Wilson M, Gyan B, Oduro D, Badu K, Botchway F, Anderson W, Bond V, Bacanamwo M, Singh S, Stiles JK. Heme-Mediated Induction of CXCL10 and Depletion of CD34+ Progenitor Cells Is Toll-Like Receptor 4 Dependent. PLoS One. 2015; 10(11):e0142328. PMID: 26555697.
      Citations: 9     Fields:    Translation:HumansCells
    13. Mir H, Singh R, Kloecker GH, Lillard JW, Singh S. CXCR6 expression in non-small cell lung carcinoma supports metastatic process via modulating metalloproteinases. Oncotarget. 2015 Apr 30; 6(12):9985-98. PMID: 25888629.
      Citations: 9     Fields:    Translation:HumansCells
    14. Gupta P, Sharma PK, Mir H, Singh R, Singh N, Kloecker GH, Lillard JW, Singh S. CCR9/CCL25 expression in non-small cell lung cancer correlates with aggressive disease and mediates key steps of metastasis. Oncotarget. 2014 Oct 30; 5(20):10170-9. PMID: 25296976.
      Citations: 20     Fields:    Translation:HumansCells
    15. Singh R, Gupta P, Kloecker GH, Singh S, Lillard JW. Expression and clinical significance of CXCR5/CXCL13 in human non-small cell lung carcinoma. Int J Oncol. 2014 Dec; 45(6):2232-40. PMID: 25271023.
      Citations: 14     Fields:    Translation:HumansCells
    16. Yahirun JJ, Hamplová D. CHILDREN'S UNION STATUS AND CONTACT WITH MOTHERS: A CROSS-NATIONAL STUDY. Demogr Res. 2014 Jan-Jun; 30:1413-1444. PMID: 22178100.
      Citations: 1     Fields:    Translation:AnimalsCells
    17. Singh R, Gupta P, Sharma PK, Ades EW, Hollingshead SK, Singh S, Lillard JW. Prediction and characterization of helper T-cell epitopes from pneumococcal surface adhesin A. Immunology. 2014 Apr; 141(4):514-30. PMID: 24138116.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    18. El-Haibi CP, Sharma P, Singh R, Gupta P, Taub DD, Singh S, Lillard JW. Differential G protein subunit expression by prostate cancer cells and their interaction with CXCR5. Mol Cancer. 2013 Jun 18; 12:64. PMID: 23773523.
      Citations: 12     Fields:    Translation:HumansCells
    19. El-Haibi CP, Singh R, Gupta P, Sharma PK, Greenleaf KN, Singh S, Lillard JW. Antibody Microarray Analysis of Signaling Networks Regulated by Cxcl13 and Cxcr5 in Prostate Cancer. J Proteomics Bioinform. 2012; 5(8):177-184. PMID: 24009409.
      Citations:    
    20. Singh R, Lillard JW, Singh S. Chemokines: key players in cancer progression and metastasis. Front Biosci (Schol Ed). 2011 Jun 01; 3:1569-82. PMID: 21622291.
      Citations: 21     Fields:    Translation:Humans
    21. Singh R, Stockard CR, Grizzle WE, Lillard JW, Singh S. Expression and histopathological correlation of CCR9 and CCL25 in ovarian cancer. Int J Oncol. 2011 Aug; 39(2):373-81. PMID: 21637913.
      Citations: 19     Fields:    Translation:HumansCells
    22. Johnson-Holiday C, Singh R, Johnson EL, Grizzle WE, Lillard JW, Singh S. CCR9-CCL25 interactions promote cisplatin resistance in breast cancer cell through Akt activation in a PI3K-dependent and FAK-independent fashion. World J Surg Oncol. 2011 May 03; 9:46. PMID: 21539750.
      Citations: 19     Fields:    Translation:HumansCells
    23. Johnson-Holiday C, Singh R, Johnson E, Singh S, Stockard CR, Grizzle WE, Lillard JW. CCL25 mediates migration, invasion and matrix metalloproteinase expression by breast cancer cells in a CCR9-dependent fashion. Int J Oncol. 2011 May; 38(5):1279-85. PMID: 21344163.
      Citations: 34     Fields:    Translation:HumansCells
    24. Sharma PK, Singh R, Novakovic KR, Eaton JW, Grizzle WE, Singh S. CCR9 mediates PI3K/AKT-dependent antiapoptotic signals in prostate cancer cells and inhibition of CCR9-CCL25 interaction enhances the cytotoxic effects of etoposide. Int J Cancer. 2010 Nov 01; 127(9):2020-30. PMID: 20127861.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    25. Johnson EL, Singh R, Singh S, Johnson-Holiday CM, Grizzle WE, Partridge EE, Lillard JW. CCL25-CCR9 interaction modulates ovarian cancer cell migration, metalloproteinase expression, and invasion. World J Surg Oncol. 2010 Jul 22; 8:62. PMID: 20649989.
      Citations: 16     Fields:    Translation:HumansCells
    26. Johnson EL, Singh R, Johnson-Holiday CM, Grizzle WE, Partridge EE, Lillard JW, Singh S. CCR9 interactions support ovarian cancer cell survival and resistance to cisplatin-induced apoptosis in a PI3K-dependent and FAK-independent fashion. J Ovarian Res. 2010 Jun 17; 3:15. PMID: 20565782.
      Citations: 14     Fields:    
    27. El Haibi CP, Sharma PK, Singh R, Johnson PR, Suttles J, Singh S, Lillard JW. PI3Kp110-, Src-, FAK-dependent and DOCK2-independent migration and invasion of CXCL13-stimulated prostate cancer cells. Mol Cancer. 2010 Apr 22; 9:85. PMID: 20412587.
      Citations: 16     Fields:    Translation:HumansCells
    28. Singh R, Singh S, Sharma PK, Singh UP, Briles DE, Hollingshead SK, Lillard JW. Helper T cell epitope-mapping reveals MHC-peptide binding affinities that correlate with T helper cell responses to pneumococcal surface protein A. PLoS One. 2010 Feb 25; 5(2):e9432. PMID: 20195541.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    29. Singh S, Singh R, Singh UP, Rai SN, Novakovic KR, Chung LW, Didier PJ, Grizzle WE, Lillard JW. Clinical and biological significance of CXCR5 expressed by prostate cancer specimens and cell lines. Int J Cancer. 2009 Nov 15; 125(10):2288-95. PMID: 19610059.
      Citations: 28     Fields:    Translation:HumansCells
    30. Singh S, Singh R, Sharma PK, Singh UP, Rai SN, Chung LW, Cooper CR, Novakovic KR, Grizzle WE, Lillard JW. Serum CXCL13 positively correlates with prostatic disease, prostate-specific antigen and mediates prostate cancer cell invasion, integrin clustering and cell adhesion. Cancer Lett. 2009 Sep 28; 283(1):29-35. PMID: 19375853.
      Citations: 32     Fields:    Translation:HumansCells
    31. Singh S, Bond VC, Powell M, Singh UP, Bumpers HL, Grizzle WE, Lillard JW. CXCR4-gp120-IIIB interactions induce caspase-mediated apoptosis of prostate cancer cells and inhibit tumor growth. . 2009 Jan; 8(1):178-84. PMID: 19139127.
      Citations:    
    32. Sakthivel SK, Singh UP, Singh S, Taub DD, Novakovic KR, Lillard JW. CXCL10 blockade protects mice from cyclophosphamide-induced cystitis. J Immune Based Ther Vaccines. 2008 Oct 28; 6:6. PMID: 18957084.
      Citations:    
    33. Sakthivel SK, Singh UP, Singh S, Taub DD, Igietseme JU, Lillard JW. CCL5 regulation of mucosal chlamydial immunity and infection. BMC Microbiol. 2008 Aug 13; 8:136. PMID: 18700040.
      Citations: 12     Fields:    Translation:AnimalsCells
    34. Singh R, Singh S, Lillard JW. Past, present, and future technologies for oral delivery of therapeutic proteins. J Pharm Sci. 2008 Jul; 97(7):2497-523. PMID: 17918721.
      Citations: 18     Fields:    Translation:Cells
    35. Singh UP, Singh R, Singh S, Karls RK, Quinn FD, Taub DD, Lillard JW. CXCL10+ T cells and NK cells assist in the recruitment and activation of CXCR3+ and CXCL11+ leukocytes during Mycobacteria-enhanced colitis. BMC Immunol. 2008 Jun 04; 9:25. PMID: 18533024.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    36. Singh UP, Singh S, Singh R, Cong Y, Taub DD, Lillard JW. CXCL10-producing mucosal CD4+ T cells, NK cells, and NKT cells are associated with chronic colitis in IL-10(-/-) mice, which can be abrogated by anti-CXCL10 antibody inhibition. J Interferon Cytokine Res. 2008 Jan; 28(1):31-43. PMID: 18370870.
      Citations: 28     Fields:    Translation:AnimalsCells
    37. Singh UP, Singh S, Singh R, Karls RK, Quinn FD, Potter ME, Lillard JW. Influence of Mycobacterium avium subsp. paratuberculosis on colitis development and specific immune responses during disease. Infect Immun. 2007 Aug; 75(8):3722-8. PMID: 17502388.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    38. Larkins TL, Nowell M, Singh S, Sanford GL. Inhibition of cyclooxygenase-2 decreases breast cancer cell motility, invasion and matrix metalloproteinase expression. BMC Cancer. 2006 Jul 10; 6:181. PMID: 16831226.
      Citations: 51     Fields:    Translation:HumansCells
    39. Palaniappan R, Singh S, Singh UP, Singh R, Ades EW, Briles DE, Hollingshead SK, Royal W, Sampson JS, Stiles JK, Taub DD, Lillard JW. CCL5 modulates pneumococcal immunity and carriage. J Immunol. 2006 Feb 15; 176(4):2346-56. PMID: 16455992.
      Citations: 16     Fields:    Translation:AnimalsCells
    40. Sarfo BY, Armah HB, Irune I, Adjei AA, Olver CS, Singh S, Lillard JW, Stiles JK. Plasmodium yoelii 17XL infection up-regulates RANTES, CCR1, CCR3 and CCR5 expression, and induces ultrastructural changes in the cerebellum. Malar J. 2005 Dec 16; 4:63. PMID: 16359553.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    41. He Q, Moore TT, Eko FO, Lyn D, Ananaba GA, Martin A, Singh S, James L, Stiles J, Black CM, Igietseme JU. Molecular basis for the potency of IL-10-deficient dendritic cells as a highly efficient APC system for activating Th1 response. J Immunol. 2005 Apr 15; 174(8):4860-9. PMID: 15814713.
      Citations: 20     Fields:    Translation:AnimalsCells
    42. Palaniappan R, Singh S, Singh UP, Sakthivel SK, Ades EW, Briles DE, Hollingshead SK, Paton JC, Sampson JS, Lillard JW. Differential PsaA-, PspA-, PspC-, and PdB-specific immune responses in a mouse model of pneumococcal carriage. Infect Immun. 2005 Feb; 73(2):1006-13. PMID: 15664944.
      Citations: 19     Fields:    Translation:AnimalsCells
    43. Singh S, Singh UP, Stiles JK, Grizzle WE, Lillard JW. Expression and functional role of CCR9 in prostate cancer cell migration and invasion. Clin Cancer Res. 2004 Dec 15; 10(24):8743-50. PMID: 15623660.
      Citations: 41     Fields:    Translation:HumansCells
    44. Singh S, Singh UP, Grizzle WE, Lillard JW. CXCL12-CXCR4 interactions modulate prostate cancer cell migration, metalloproteinase expression and invasion. Lab Invest. 2004 Dec; 84(12):1666-76. PMID: 15467730.
      Citations: 88     Fields:    Translation:HumansCells
    45. Singh UP, Singh S, Ravichandran P, Taub DD, Lillard JW. Viral macrophage-inflammatory protein-II: a viral chemokine that differentially affects adaptive mucosal immunity compared with its mammalian counterparts. J Immunol. 2004 Nov 01; 173(9):5509-16. PMID: 15494499.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    46. Singh UP, Singh S, Boyaka PN, McGhee JR, Lillard JW. Granulocyte chemotactic protein-2 mediates adaptive immunity in part through IL-8Rbeta interactions. J Leukoc Biol. 2004 Dec; 76(6):1240-7. PMID: 15356099.
      Citations: 2     Fields:    Translation:AnimalsCells
    47. Singh UP, Singh S, Iqbal N, Weaver CT, McGhee JR, Lillard JW. IFN-gamma-inducible chemokines enhance adaptive immunity and colitis. J Interferon Cytokine Res. 2003 Oct; 23(10):591-600. PMID: 14585199.
      Citations: 27     Fields:    Translation:AnimalsCells
    48. Singh UP, Singh S, Taub DD, Lillard JW. Inhibition of IFN-gamma-inducible protein-10 abrogates colitis in IL-10-/- mice. J Immunol. 2003 Aug 01; 171(3):1401-6. PMID: 12874231.
      Citations: 49     Fields:    Translation:AnimalsCells
    49. Lillard JW, Singh UP, Boyaka PN, Singh S, Taub DD, McGhee JR. MIP-1alpha and MIP-1beta differentially mediate mucosal and systemic adaptive immunity. Blood. 2003 Feb 01; 101(3):807-14. PMID: 12393512.
      Citations: 31     Fields:    Translation:AnimalsCells
    Singh's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (276)
    Explore
    _
    Co-Authors (8)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _
    RCMI CC is supported by the National Institute on Minority Health and Health Disparities, National Institutes of Health (NIH), through Grant Number U24MD015970. The contents of this site are solely the responsibility of the authors and do not necessarily represent the official views of the NIH

    For technical support please contact support