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Shailesh Singh

Title
Faculty RankProfessor
InstitutionMorehouse School of Medicine
DepartmentMicrobiology, Biochemistry, & Immunology
Address720 Westveiw Drive, SW
Hugh Gloster building
Atlanta GA 30310
Phone4047565784
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    Collapse Research 
    Collapse research activities and funding
    R21CA169716     (SINGH, SHAILESH)Apr 1, 2013 - Sep 30, 2016
    NIH
    Prostate Cancer Chemoprevention using a Natural Agent
    Role: Principal Investigator
    SC1CA180212     (SINGH, SHAILESH)Apr 1, 2013 - Mar 31, 2021
    NIH
    Role of CCL25-CCR9 in Prostate Cancer
    Role: Principal Investigator
    U01CA179701     (SINGH, SHAILESH)Sep 1, 2013 - Aug 30, 2019
    NIH
    Role of chemokine receptor in disparities associated with prostate cancer progres
    Role: Principal Investigator
    R41MD010320     (SINGH, SHAILESH)Aug 1, 2015 - Jul 31, 2018
    NIH
    Anti-CXCL13 mAb to mitigate prostate cancer health disparities
    Role: Principal Investigator
    R41CA214080     (SINGH, SHAILESH)Jan 1, 2017 - Dec 31, 2018
    NIH
    Anti-CCL25 mAb to treat castration resistant prostate cancer
    Role: Principal Investigator
    R01CA256724     (SINGH, SHAILESH)Jul 1, 2022 - Dec 31, 2027
    NIH
    The interplay of social and molecular determinants in lung cancer disparity
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kaur P, Singh SK, Mishra MK, Singh S, Singh R. Promising Combinatorial Therapeutic Strategies against Non-Small Cell Lung Cancer. Cancers (Basel). 2024 Jun 12; 16(12). PMID: 38927911.
      Citations:    
    2. Brock BA, Mir H, Flenaugh EL, Oprea-Ilies G, Singh R, Singh S. Social and Biological Determinants in Lung Cancer Disparity. Cancers (Basel). 2024 Jan 31; 16(3). PMID: 38339362.
      Citations:    
    3. Mir H, Singh S. Neutrophils: a roadblock for immunotherapy. Nat Rev Cancer. 2022 07; 22(7):378-379. PMID: 35292762.
      Citations: 4     Fields:    Translation:HumansCells
    4. Upadhyaya HD, Wang L, Prakash CS, Liu Y, Gao L, Meng R, Seetharam K, Gowda CLL, Ganesamurthy K, Singh SK, Kumar R, Li J, Wang YH. Genome-wide association mapping identifies an SNF4 ortholog that impacts biomass and sugar yield in sorghum and sugarcane. J Exp Bot. 2022 06 02; 73(11):3584-3596. PMID: 35290448.
      Citations: 3     Fields:    Translation:Animals
    5. Haynes T, Oprea-Ilies G, Manne U, Singh R, Singh S, Mir H. The interplay of pineal hormones and socioeconomic status leading to colorectal cancer disparity. Transl Oncol. 2022 Feb; 16:101330. PMID: 34990909.
      Citations:    
    6. Singh SK, Singh S, Singh R. Targeting novel coronavirus SARS-CoV-2 spike protein with phytoconstituents of Momordica charantia. J Ovarian Res. 2021 Sep 27; 14(1):126. PMID: 34579761.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    7. Mir H, Kapur N, Gales DN, Sharma PK, Oprea-Ilies G, Johnson AT, Singh R, Singh S. CXCR6-CXCL16 Axis Promotes Breast Cancer by Inducing Oncogenic Signaling. Cancers (Basel). 2021 Jul 16; 13(14). PMID: 34298782.
      Citations:    
    8. Mir H, Singh S. CCL25 Signaling in the Tumor Microenvironment. Adv Exp Med Biol. 2021; 1302:99-111. PMID: 34286444.
      Citations: 3     Fields:    Translation:Cells
    9. King Thomas J, Mir H, Kapur N, Singh S. Racial Differences in Immunological Landscape Modifiers Contributing to Disparity in Prostate Cancer. Cancers (Basel). 2019 Nov 25; 11(12). PMID: 31769418.
      Citations:    
    10. Mondal A, Saha N, Rajput A, Singh SK, Roy B, Husain SM. Chemoenzymatic reduction of citreorosein and its implications on aloe-emodin and rugulosin C (bio)synthesis. Org Biomol Chem. 2019 10 14; 17(38):8711-8715. PMID: 31549123.
      Citations:    Fields:    Translation:AnimalsCells
    11. Saunders IT, Mir H, Kapur N, Singh S. Emodin inhibits colon cancer by altering BCL-2 family proteins and cell survival pathways. Cancer Cell Int. 2019; 19:98. PMID: 31011292.
      Citations:    
    12. Kapur N, Mir H, Sonpavde GP, Jain S, Bae S, Lillard JW, Singh S. Prostate cancer cells hyper-activate CXCR6 signaling by cleaving CXCL16 to overcome effect of docetaxel. Cancer Lett. 2019 07 10; 454:1-13. PMID: 30974114.
      Citations: 16     Fields:    Translation:HumansCells
    13. Thomas JK, Mir H, Kapur N, Bae S, Singh S. CC chemokines are differentially expressed in Breast Cancer and are associated with disparity in overall survival. Sci Rep. 2019 03 08; 9(1):4014. PMID: 30850664.
      Citations: 34     Fields:    Translation:Humans
    14. Mir H, Kaur G, Kapur N, Bae S, Lillard JW, Singh S. Higher CXCL16 exodomain is associated with aggressive ovarian cancer and promotes the disease by CXCR6 activation and MMP modulation. Sci Rep. 2019 02 21; 9(1):2527. PMID: 30792527.
      Citations: 18     Fields:    Translation:HumansCells
    15. Carriere PP, Kapur N, Mir H, Ward AB, Singh S. Cinnamtannin B-1 inhibits cell survival molecules and induces apoptosis in colon cancer. Int J Oncol. 2018 Oct; 53(4):1442-1454. PMID: 30066888.
      Citations: 5     Fields:    Translation:HumansCells
    16. Ward AB, Mir H, Kapur N, Gales DN, Carriere PP, Singh S. Quercetin inhibits prostate cancer by attenuating cell survival and inhibiting anti-apoptotic pathways. World J Surg Oncol. 2018 Jun 14; 16(1):108. PMID: 29898731.
      Citations: 66     Fields:    Translation:HumansCells
    17. Singh S, Vatsa D, Tomar S, Aneja GK, S Arya TV. Cardiac complications in people living with human immunodeficiency virus/acquired immunodeficiency syndrome and their association with CD4+ T-cell count - A cross sectional study. Indian J Sex Transm Dis AIDS. 2018 Jan-Jun; 39(1):23-27. PMID: 30187022.
      Citations:    
    18. King J, Mir H, Singh S. Association of Cytokines and Chemokines in Pathogenesis of Breast Cancer. Prog Mol Biol Transl Sci. 2017; 151:113-136. PMID: 29096891.
      Citations: 27     Fields:    Translation:Humans
    19. Kapur N, Mir H, Clark Iii CE, Krishnamurti U, Beech DJ, Lillard JW, Singh S. CCR6 expression in colon cancer is associated with advanced disease and supports epithelial-to-mesenchymal transition. Br J Cancer. 2016 06 14; 114(12):1343-51. PMID: 27149649.
      Citations: 25     Fields:    Translation:HumansCells
    20. Singh R, Kapur N, Mir H, Singh N, Lillard JW, Singh S. CXCR6-CXCL16 axis promotes prostate cancer by mediating cytoskeleton rearrangement via Ezrin activation and av?3 integrin clustering. Oncotarget. 2016 Feb 09; 7(6):7343-53. PMID: 26799186.
      Citations: 37     Fields:    Translation:HumansCells
    21. Dickinson-Copeland CM, Wilson NO, Liu M, Driss A, Salifu H, Adjei AA, Wilson M, Gyan B, Oduro D, Badu K, Botchway F, Anderson W, Bond V, Bacanamwo M, Singh S, Stiles JK. Correction: Heme-Mediated Induction of CXCL10 and Depletion of CD34+ Progenitor Cells Is Toll-Like Receptor 4 Dependent. PLoS One. 2016; 11(1):e0147460. PMID: 26765684.
      Citations: 1     Fields:    
    22. Mir H, Kapur N, Singh R, Sonpavde G, Lillard JW, Singh S. Andrographolide inhibits prostate cancer by targeting cell cycle regulators, CXCR3 and CXCR7 chemokine receptors. Cell Cycle. 2016; 15(6):819-26. PMID: 27029529.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    23. Dickinson-Copeland CM, Wilson NO, Liu M, Driss A, Salifu H, Adjei AA, Wilson M, Gyan B, Oduro D, Badu K, Botchway F, Anderson W, Bond V, Bacanamwo M, Singh S, Stiles JK. Heme-Mediated Induction of CXCL10 and Depletion of CD34+ Progenitor Cells Is Toll-Like Receptor 4 Dependent. PLoS One. 2015; 10(11):e0142328. PMID: 26555697.
      Citations: 14     Fields:    Translation:HumansCells
    24. Mir H, Singh R, Kloecker GH, Lillard JW, Singh S. CXCR6 expression in non-small cell lung carcinoma supports metastatic process via modulating metalloproteinases. Oncotarget. 2015 Apr 30; 6(12):9985-98. PMID: 25888629.
      Citations: 16     Fields:    Translation:HumansCells
    25. Gupta P, Sharma PK, Mir H, Singh R, Singh N, Kloecker GH, Lillard JW, Singh S. CCR9/CCL25 expression in non-small cell lung cancer correlates with aggressive disease and mediates key steps of metastasis. Oncotarget. 2014 Oct 30; 5(20):10170-9. PMID: 25296976.
      Citations: 28     Fields:    Translation:HumansCells
    26. Singh R, Gupta P, Kloecker GH, Singh S, Lillard JW. Expression and clinical significance of CXCR5/CXCL13 in human non-small cell lung carcinoma. Int J Oncol. 2014 Dec; 45(6):2232-40. PMID: 25271023.
      Citations: 41     Fields:    Translation:HumansCells
    27. Singh R, Gupta P, Sharma PK, Ades EW, Hollingshead SK, Singh S, Lillard JW. Prediction and characterization of helper T-cell epitopes from pneumococcal surface adhesin A. Immunology. 2014 Apr; 141(4):514-30. PMID: 24138116.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    28. Kumar Goyal N, Goel A, Sankhwar SN, Mandal S, Singhai A, Singh S. Cheek metastasis from a bladder tumor: unusual presentation of an aggressive disease. Urologia. 2013 Sep-Dec; 80(4):317-21. PMID: 23813285.
      Citations: 2     Fields:    Translation:Humans
    29. El-Haibi CP, Sharma P, Singh R, Gupta P, Taub DD, Singh S, Lillard JW. Differential G protein subunit expression by prostate cancer cells and their interaction with CXCR5. Mol Cancer. 2013 Jun 18; 12:64. PMID: 23773523.
      Citations: 29     Fields:    Translation:HumansCells
    30. El-Haibi CP, Singh R, Gupta P, Sharma PK, Greenleaf KN, Singh S, Lillard JW. Antibody Microarray Analysis of Signaling Networks Regulated by Cxcl13 and Cxcr5 in Prostate Cancer. J Proteomics Bioinform. 2012; 5(8):177-184. PMID: 24009409.
      Citations:    
    31. Singh R, Singh S, Briles DE, Taub DD, Hollingshead SK, Lillard JW. CCL5-independent helper T lymphocyte responses to immuno-dominant pneumococcal surface protein A epitopes. Vaccine. 2012 Feb 01; 30(6):1181-90. PMID: 22178100.
      Citations:    Fields:    Translation:AnimalsCells
    32. Singh R, Lillard JW, Singh S. Chemokines: key players in cancer progression and metastasis. Front Biosci (Schol Ed). 2011 06 01; 3(4):1569-82. PMID: 21622291.
      Citations: 33     Fields:    Translation:Humans
    33. Singh R, Stockard CR, Grizzle WE, Lillard JW, Singh S. Expression and histopathological correlation of CCR9 and CCL25 in ovarian cancer. Int J Oncol. 2011 Aug; 39(2):373-81. PMID: 21637913.
      Citations: 30     Fields:    Translation:HumansCells
    34. Johnson-Holiday C, Singh R, Johnson EL, Grizzle WE, Lillard JW, Singh S. CCR9-CCL25 interactions promote cisplatin resistance in breast cancer cell through Akt activation in a PI3K-dependent and FAK-independent fashion. World J Surg Oncol. 2011 May 03; 9:46. PMID: 21539750.
      Citations: 25     Fields:    Translation:HumansCells
    35. Johnson-Holiday C, Singh R, Johnson E, Singh S, Stockard CR, Grizzle WE, Lillard JW. CCL25 mediates migration, invasion and matrix metalloproteinase expression by breast cancer cells in a CCR9-dependent fashion. Int J Oncol. 2011 May; 38(5):1279-85. PMID: 21344163.
      Citations: 47     Fields:    Translation:HumansCells
    36. Sharma PK, Singh R, Novakovic KR, Eaton JW, Grizzle WE, Singh S. CCR9 mediates PI3K/AKT-dependent antiapoptotic signals in prostate cancer cells and inhibition of CCR9-CCL25 interaction enhances the cytotoxic effects of etoposide. Int J Cancer. 2010 Nov 01; 127(9):2020-30. PMID: 20127861.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    37. Johnson EL, Singh R, Singh S, Johnson-Holiday CM, Grizzle WE, Partridge EE, Lillard JW. CCL25-CCR9 interaction modulates ovarian cancer cell migration, metalloproteinase expression, and invasion. World J Surg Oncol. 2010 Jul 22; 8:62. PMID: 20649989.
      Citations: 22     Fields:    Translation:HumansCells
    38. Johnson EL, Singh R, Johnson-Holiday CM, Grizzle WE, Partridge EE, Lillard JW, Singh S. CCR9 interactions support ovarian cancer cell survival and resistance to cisplatin-induced apoptosis in a PI3K-dependent and FAK-independent fashion. J Ovarian Res. 2010 Jun 17; 3:15. PMID: 20565782.
      Citations: 20     Fields:    
    39. El Haibi CP, Sharma PK, Singh R, Johnson PR, Suttles J, Singh S, Lillard JW. PI3Kp110-, Src-, FAK-dependent and DOCK2-independent migration and invasion of CXCL13-stimulated prostate cancer cells. Mol Cancer. 2010 Apr 22; 9:85. PMID: 20412587.
      Citations: 31     Fields:    Translation:HumansCells
    40. Singh R, Singh S, Sharma PK, Singh UP, Briles DE, Hollingshead SK, Lillard JW. Helper T cell epitope-mapping reveals MHC-peptide binding affinities that correlate with T helper cell responses to pneumococcal surface protein A. PLoS One. 2010 Feb 25; 5(2):e9432. PMID: 20195541.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    41. Singh S, Singh R, Singh UP, Rai SN, Novakovic KR, Chung LW, Didier PJ, Grizzle WE, Lillard JW. Clinical and biological significance of CXCR5 expressed by prostate cancer specimens and cell lines. Int J Cancer. 2009 Nov 15; 125(10):2288-95. PMID: 19610059.
      Citations: 39     Fields:    Translation:HumansCells
    42. Singh S, Singh R, Sharma PK, Singh UP, Rai SN, Chung LW, Cooper CR, Novakovic KR, Grizzle WE, Lillard JW. Serum CXCL13 positively correlates with prostatic disease, prostate-specific antigen and mediates prostate cancer cell invasion, integrin clustering and cell adhesion. Cancer Lett. 2009 Sep 28; 283(1):29-35. PMID: 19375853.
      Citations: 48     Fields:    Translation:HumansCells
    43. Singh S, Bond VC, Powell M, Singh UP, Bumpers HL, Grizzle WE, Lillard JW. CXCR4-gp120-IIIB interactions induce caspase-mediated apoptosis of prostate cancer cells and inhibit tumor growth. Mol Cancer Ther. 2009 Jan; 8(1):178-84. PMID: 19139127.
      Citations: 6     Fields:    Translation:AnimalsCells
    44. Sakthivel SK, Singh UP, Singh S, Taub DD, Novakovic KR, Lillard JW. CXCL10 blockade protects mice from cyclophosphamide-induced cystitis. J Immune Based Ther Vaccines. 2008 Oct 28; 6:6. PMID: 18957084.
      Citations:    
    45. Sakthivel SK, Singh UP, Singh S, Taub DD, Igietseme JU, Lillard JW. CCL5 regulation of mucosal chlamydial immunity and infection. BMC Microbiol. 2008 Aug 13; 8:136. PMID: 18700040.
      Citations: 16     Fields:    Translation:AnimalsCells
    46. Singh R, Singh S, Lillard JW. Past, present, and future technologies for oral delivery of therapeutic proteins. J Pharm Sci. 2008 Jul; 97(7):2497-523. PMID: 17918721.
      Citations: 31     Fields:    Translation:Cells
    47. Singh UP, Singh R, Singh S, Karls RK, Quinn FD, Taub DD, Lillard JW. CXCL10+ T cells and NK cells assist in the recruitment and activation of CXCR3+ and CXCL11+ leukocytes during Mycobacteria-enhanced colitis. BMC Immunol. 2008 Jun 04; 9:25. PMID: 18533024.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    48. Singh UP, Singh S, Singh R, Cong Y, Taub DD, Lillard JW. CXCL10-producing mucosal CD4+ T cells, NK cells, and NKT cells are associated with chronic colitis in IL-10(-/-) mice, which can be abrogated by anti-CXCL10 antibody inhibition. J Interferon Cytokine Res. 2008 Jan; 28(1):31-43. PMID: 18370870.
      Citations: 30     Fields:    Translation:AnimalsCells
    49. Singh UP, Singh S, Singh R, Karls RK, Quinn FD, Potter ME, Lillard JW. Influence of Mycobacterium avium subsp. paratuberculosis on colitis development and specific immune responses during disease. Infect Immun. 2007 Aug; 75(8):3722-8. PMID: 17502388.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    50. Larkins TL, Nowell M, Singh S, Sanford GL. Inhibition of cyclooxygenase-2 decreases breast cancer cell motility, invasion and matrix metalloproteinase expression. BMC Cancer. 2006 Jul 10; 6:181. PMID: 16831226.
      Citations: 62     Fields:    Translation:HumansCells
    51. Palaniappan R, Singh S, Singh UP, Singh R, Ades EW, Briles DE, Hollingshead SK, Royal W, Sampson JS, Stiles JK, Taub DD, Lillard JW. CCL5 modulates pneumococcal immunity and carriage. J Immunol. 2006 Feb 15; 176(4):2346-56. PMID: 16455992.
      Citations: 21     Fields:    Translation:AnimalsCells
    52. Sarfo BY, Armah HB, Irune I, Adjei AA, Olver CS, Singh S, Lillard JW, Stiles JK. Plasmodium yoelii 17XL infection up-regulates RANTES, CCR1, CCR3 and CCR5 expression, and induces ultrastructural changes in the cerebellum. Malar J. 2005 Dec 16; 4:63. PMID: 16359553.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    53. He Q, Moore TT, Eko FO, Lyn D, Ananaba GA, Martin A, Singh S, James L, Stiles J, Black CM, Igietseme JU. Molecular basis for the potency of IL-10-deficient dendritic cells as a highly efficient APC system for activating Th1 response. J Immunol. 2005 Apr 15; 174(8):4860-9. PMID: 15814713.
      Citations: 24     Fields:    Translation:AnimalsCells
    54. Palaniappan R, Singh S, Singh UP, Sakthivel SK, Ades EW, Briles DE, Hollingshead SK, Paton JC, Sampson JS, Lillard JW. Differential PsaA-, PspA-, PspC-, and PdB-specific immune responses in a mouse model of pneumococcal carriage. Infect Immun. 2005 Feb; 73(2):1006-13. PMID: 15664944.
      Citations: 19     Fields:    Translation:AnimalsCells
    55. Singh S, Singh UP, Stiles JK, Grizzle WE, Lillard JW. Expression and functional role of CCR9 in prostate cancer cell migration and invasion. Clin Cancer Res. 2004 Dec 15; 10(24):8743-50. PMID: 15623660.
      Citations: 50     Fields:    Translation:HumansCells
    56. Singh S, Singh UP, Grizzle WE, Lillard JW. CXCL12-CXCR4 interactions modulate prostate cancer cell migration, metalloproteinase expression and invasion. Lab Invest. 2004 Dec; 84(12):1666-76. PMID: 15467730.
      Citations: 113     Fields:    Translation:HumansCells
    57. Singh UP, Singh S, Ravichandran P, Taub DD, Lillard JW. Viral macrophage-inflammatory protein-II: a viral chemokine that differentially affects adaptive mucosal immunity compared with its mammalian counterparts. J Immunol. 2004 Nov 01; 173(9):5509-16. PMID: 15494499.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    58. Singh UP, Singh S, Boyaka PN, McGhee JR, Lillard JW. Granulocyte chemotactic protein-2 mediates adaptive immunity in part through IL-8Rbeta interactions. J Leukoc Biol. 2004 Dec; 76(6):1240-7. PMID: 15356099.
      Citations: 2     Fields:    Translation:AnimalsCells
    59. Singh UP, Singh S, Iqbal N, Weaver CT, McGhee JR, Lillard JW. IFN-gamma-inducible chemokines enhance adaptive immunity and colitis. J Interferon Cytokine Res. 2003 Oct; 23(10):591-600. PMID: 14585199.
      Citations: 29     Fields:    Translation:AnimalsCells
    60. Singh UP, Singh S, Taub DD, Lillard JW. Inhibition of IFN-gamma-inducible protein-10 abrogates colitis in IL-10-/- mice. J Immunol. 2003 Aug 01; 171(3):1401-6. PMID: 12874231.
      Citations: 60     Fields:    Translation:AnimalsCells
    61. Pandey M, Sharma LB, Singh S, Shukla VK. Erythrocyte membrane fatty acid profile and saturation index in gallbladder carcinogenesis: a case-control study. World J Surg Oncol. 2003 May 07; 1(1):5. PMID: 12793905.
      Citations: 5     Fields:    
    62. Lillard JW, Singh UP, Boyaka PN, Singh S, Taub DD, McGhee JR. MIP-1alpha and MIP-1beta differentially mediate mucosal and systemic adaptive immunity. Blood. 2003 Feb 01; 101(3):807-14. PMID: 12393512.
      Citations: 42     Fields:    Translation:AnimalsCells
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