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Brian Hermann

TitleAssistant Professor
Faculty RankAssistant Professor
InstitutionUniversity of Texas at San Antonio
Address1 UTSA Circle
BSB 2.03.16
San Antonio TX 78249
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    Dr. Hermann’s laboratory studies the basic biology of spermatogonial stem cells (SSCs), which are adult-tissue stem cells responsible for sperm production in the mammalian testis and which are essential for male fertility. Ongoing studies in the lab are focused on 1) determining how these cells are regulated and behave like stem cells, 2) how SSC loss due to sterilizing treatments can be prevented, 3) how SSCs participate in the etiology of male infertility, and 4) how the male germline ages. The lab’s work has potential implications for basic stem cell biology, reproduction, as well as translational significance for treatment and prevention of male infertility. The approaches used in the lab are multidisciplinary, including animal models (rodents, primates), human tissues, an in vitro SSC culture system, an in vivo transplantation assay for stem cells, various wide-field microscopy techniques, as well as conventional and high-throughput molecular biology and genomic approaches.

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Matilionyte G, Forsyth G, Guo J, Rimmer MP, Hermann BP, Anderson RA, Mitchell RT. Granulocyte-colony stimulating factor does not prevent in vitro cisplatin-induced germ cell reduction in immature human and mouse testis. BMC Cancer. 2023 Mar 16; 23(1):251. PMID: 36922758.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Singh A, Hermann BP. Conserved Transcriptome Features Define Prepubertal Primate Spermatogonial Stem Cells as Adark Spermatogonia and Identify Unique Regulators. Int J Mol Sci. 2023 Mar 01; 24(5). PMID: 36902187.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. Fernandez RF, Wilson ES, Diaz V, Mart?nez-Gardeazabal J, Foguth R, Cannon JR, Jackson SN, Hermann BP, Eells JB, Ellis JM. Lipid metabolism in dopaminergic neurons influences light entrainment. J Neurochem. 2023 Feb 23. PMID: 36815399.
      Citations:    Fields:    
    4. Seita Y, Cheng K, McCarrey JR, Yadu N, Cheeseman IH, Bagwell A, Ross CN, Santana Toro I, Yen LH, Vargas S, Navara CS, Hermann BP, Sasaki K. Efficient generation of marmoset primordial germ cell-like cells using induced pluripotent stem cells. Elife. 2023 01 31; 12. PMID: 36719274.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    5. Kirsanov O, Johnson T, Malachowski T, Niedenberger BA, Gilbert EA, Bhowmick D, Ozdinler PH, Gray DA, Fisher-Wellman K, Hermann BP, Geyer CB. Modeling mammalian spermatogonial differentiation and meiotic initiation in vitro. Development. 2022 Nov 15; 149(22). PMID: 36250451.
      Citations:    Fields:    Translation:AnimalsCells
    6. Peart NJ, Johnson TA, Lee S, Sears MJ, Yang F, Quesnel-Valli?res M, Feng H, Recinos Y, Barash Y, Zhang C, Hermann BP, Wang PJ, Geyer CB, Carstens RP. The germ cell-specific RNA binding protein RBM46 is essential for spermatogonial differentiation in mice. PLoS Genet. 2022 09; 18(9):e1010416. PMID: 36129965.
      Citations: 1     Fields:    Translation:AnimalsCells
    7. Fernandez RF, Pereyra AS, Diaz V, Wilson ES, Litwa KA, Mart?nez-Gardeazabal J, Jackson SN, Brenna JT, Hermann BP, Eells JB, Ellis JM. Acyl-CoA synthetase 6 is required for brain docosahexaenoic acid retention and neuroprotection during aging. JCI Insight. 2021 06 08; 6(11). PMID: 34100386.
      Citations: 1     Fields:    Translation:Animals
    8. Suzuki S, McCarrey JR, Hermann BP. Differential RA responsiveness among subsets of mouse late progenitor spermatogonia. Reproduction. 2021 05 05; 161(6):645-655. PMID: 33835049.
      Citations: 3     Fields:    Translation:AnimalsCells
    9. Suzuki S, McCarrey JR, Hermann BP. An mTORC1-dependent switch orchestrates the transition between mouse spermatogonial stem cells and clones of progenitor spermatogonia. Cell Rep. 2021 02 16; 34(7):108752. PMID: 33596419.
      Citations: 8     Fields:    Translation:AnimalsCells
    10. Hwang YS, Suzuki S, Seita Y, Ito J, Sakata Y, Aso H, Sato K, Hermann BP, Sasaki K. Reconstitution of prospermatogonial specification in vitro from human induced pluripotent stem cells. Nat Commun. 2020 11 09; 11(1):5656. PMID: 33168808.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    11. Cheng K, Chen IC, Cheng CE, Mutoji K, Hale BJ, Hermann BP, Geyer CB, Oatley JM, McCarrey JR. Unique Epigenetic Programming Distinguishes Regenerative Spermatogonial Stem Cells in the Developing Mouse Testis. iScience. 2020 Oct 23; 23(10):101596. PMID: 33083754.
    12. Suzuki S, Diaz VD, Hermann BP. What has single-cell RNA-seq taught us about mammalian spermatogenesis? Biol Reprod. 2019 09 01; 101(3):617-634. PMID: 31077285.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    13. Hale BJ, Fernandez RF, Kim SQ, Diaz VD, Jackson SN, Liu L, Brenna JT, Hermann BP, Geyer CB, Ellis JM. Acyl-CoA synthetase 6 enriches seminiferous tubules with the ?-3 fatty acid docosahexaenoic acid and is required for male fertility in the mouse. J Biol Chem. 2019 09 27; 294(39):14394-14405. PMID: 31399511.
      Citations: 11     Fields:    Translation:Animals
    14. Velte EK, Niedenberger BA, Serra ND, Singh A, Roa-DeLaCruz L, Hermann BP, Geyer CB. Differential RA responsiveness directs formation of functionally distinct spermatogonial populations at the initiation of spermatogenesis in the mouse. Development. 2019 05 13; 146(12). PMID: 31023878.
      Citations: 17     Fields:    Translation:AnimalsCells
    15. Hermann BP, Cheng K, Singh A, Roa-De La Cruz L, Mutoji KN, Chen IC, Gildersleeve H, Lehle JD, Mayo M, Westernstr?er B, Law NC, Oatley MJ, Velte EK, Niedenberger BA, Fritze D, Silber S, Geyer CB, Oatley JM, McCarrey JR. The Mammalian Spermatogenesis Single-Cell Transcriptome, from Spermatogonial Stem Cells to Spermatids. Cell Rep. 2018 11 06; 25(6):1650-1667.e8. PMID: 30404016.
      Citations: 182     Fields:    Translation:HumansAnimalsCells
    16. Niedenberger BA, Cook K, Baena V, Serra ND, Velte EK, Agno JE, Litwa KA, Terasaki M, Hermann BP, Matzuk MM, Geyer CB. Dynamic cytoplasmic projections connect mammalian spermatogonia in vivo. Development. 2018 08 13; 145(15). PMID: 29980567.
      Citations: 7     Fields:    Translation:AnimalsCells
    17. Kotzur T, Benavides-Garcia R, Mecklenburg J, Sanchez JR, Reilly M, Hermann BP. Granulocyte colony-stimulating factor (G-CSF) promotes spermatogenic regeneration from surviving spermatogonia after high-dose alkylating chemotherapy. Reprod Biol Endocrinol. 2017 Jan 11; 15(1):7. PMID: 28077131.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    18. Mutoji K, Singh A, Nguyen T, Gildersleeve H, Kaucher AV, Oatley MJ, Oatley JM, Velte EK, Geyer CB, Cheng K, McCarrey JR, Hermann BP. TSPAN8 Expression Distinguishes Spermatogonial Stem Cells in the Prepubertal Mouse Testis. Biol Reprod. 2016 12; 95(6):117. PMID: 27733379.
      Citations: 19     Fields:    Translation:AnimalsCells
    19. Lovelace DL, Gao Z, Mutoji K, Song YC, Ruan J, Hermann BP. The regulatory repertoire of PLZF and SALL4 in undifferentiated spermatogonia. Development. 2016 06 01; 143(11):1893-906. PMID: 27068105.
      Citations: 38     Fields:    Translation:AnimalsCells
    20. Mecklenburg JM, Hermann BP. Mechanisms Regulating Spermatogonial Differentiation. Results Probl Cell Differ. 2016; 58:253-87. PMID: 27300182.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    21. Wechsler ME, Hermann BP, Bizios R. Adult Human Mesenchymal Stem Cell Differentiation at the Cell Population and Single-Cell Levels Under Alternating Electric Current. Tissue Eng Part C Methods. 2016 02; 22(2):155-164. PMID: 26573771.
      Citations: 10     Fields:    
    22. Hermann BP, Mutoji KN, Velte EK, Ko D, Oatley JM, Geyer CB, McCarrey JR. Transcriptional and translational heterogeneity among neonatal mouse spermatogonia. Biol Reprod. 2015 Feb; 92(2):54. PMID: 25568304.
      Citations: 45     Fields:    Translation:AnimalsCells
    23. Benavides-Garcia R, Joachim R, Pina NA, Mutoji KN, Reilly MA, Hermann BP. Granulocyte colony-stimulating factor prevents loss of spermatogenesis after sterilizing busulfan chemotherapy. Fertil Steril. 2015 Jan; 103(1):270-80.e8. PMID: 25439845.
      Citations: 17     Fields:    Translation:Animals
    24. Dovey SL, Valli H, Hermann BP, Sukhwani M, Donohue J, Castro CA, Chu T, Sanfilippo JS, Orwig KE. Eliminating malignant contamination from therapeutic human spermatogonial stem cells. J Clin Invest. 2013 Apr; 123(4):1833-43. PMID: 23549087.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    25. Hermann BP, Sukhwani M, Winkler F, Pascarella JN, Peters KA, Sheng Y, Valli H, Rodriguez M, Ezzelarab M, Dargo G, Peterson K, Masterson K, Ramsey C, Ward T, Lienesch M, Volk A, Cooper DK, Thomson AW, Kiss JE, Penedo MC, Schatten GP, Mitalipov S, Orwig KE. Spermatogonial stem cell transplantation into rhesus testes regenerates spermatogenesis producing functional sperm. Cell Stem Cell. 2012 Nov 02; 11(5):715-26. PMID: 23122294.
      Citations: 137     Fields:    Translation:AnimalsCells
    26. Easley CA, Phillips BT, McGuire MM, Barringer JM, Valli H, Hermann BP, Simerly CR, Rajkovic A, Miki T, Orwig KE, Schatten GP. Direct differentiation of human pluripotent stem cells into haploid spermatogenic cells. Cell Rep. 2012 Sep 27; 2(3):440-6. PMID: 22921399.
      Citations: 101     Fields:    Translation:HumansAnimalsCells
    27. Hermann BP, Sukhwani M, Salati J, Sheng Y, Chu T, Orwig KE. Separating spermatogonia from cancer cells in contaminated prepubertal primate testis cell suspensions. Hum Reprod. 2011 Dec; 26(12):3222-31. PMID: 22016413.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    28. Hermann BP, Phillips BT, Orwig KE. The elusive spermatogonial stem cell marker? Biol Reprod. 2011 Aug; 85(2):221-3. PMID: 21565995.
      Citations: 7     Fields:    Translation:AnimalsCells
    29. Ben-Yehudah A, Easley CA, Hermann BP, Castro C, Simerly C, Orwig KE, Mitalipov S, Schatten G. Systems biology discoveries using non-human primate pluripotent stem and germ cells: novel gene and genomic imprinting interactions as well as unique expression patterns. Stem Cell Res Ther. 2010 Aug 05; 1(3):24. PMID: 20699013.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    30. Hermann BP, Sukhwani M, Hansel MC, Orwig KE. Spermatogonial stem cells in higher primates: are there differences from those in rodents? Reproduction. 2010 Mar; 139(3):479-93. PMID: 19880674.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    31. Hermann BP, Sukhwani M, Simorangkir DR, Chu T, Plant TM, Orwig KE. Molecular dissection of the male germ cell lineage identifies putative spermatogonial stem cells in rhesus macaques. Hum Reprod. 2009 Jul; 24(7):1704-16. PMID: 19336441.
      Citations: 62     Fields:    Translation:AnimalsCells
    32. Hermann BP, Hornbaker K, Rice DA, Sawadogo M, Heckert LL. In vivo regulation of follicle-stimulating hormone receptor by the transcription factors upstream stimulatory factor 1 and upstream stimulatory factor 2 is cell specific. Endocrinology. 2008 Oct; 149(10):5297-306. PMID: 18566134.
      Citations: 14     Fields:    Translation:AnimalsCells
    33. Hermann BP, Sukhwani M, Lin CC, Sheng Y, Tomko J, Rodriguez M, Shuttleworth JJ, McFarland D, Hobbs RM, Pandolfi PP, Schatten GP, Orwig KE. Characterization, cryopreservation, and ablation of spermatogonial stem cells in adult rhesus macaques. Stem Cells. 2007 Sep; 25(9):2330-8. PMID: 17585169.
      Citations: 98     Fields:    Translation:AnimalsCells
    34. Hermann BP, Hornbaker KI, Maran RR, Heckert LL. Distal regulatory elements are required for Fshr expression, in vivo. Mol Cell Endocrinol. 2007 Jan 02; 260-262:49-58. PMID: 17097219.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    35. Hermann BP, Heckert LL. Transcriptional regulation of the FSH receptor: new perspectives. Mol Cell Endocrinol. 2007 Jan 02; 260-262:100-8. PMID: 17084019.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    36. Hermann BP, Heckert LL. Silencing of Fshr occurs through a conserved, hypersensitive site in the first intron. Mol Endocrinol. 2005 Aug; 19(8):2112-31. PMID: 15817654.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
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