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Katherine Serafine

TitleDr.
Faculty RankAssistant Professor
InstitutionUniversity of Texas at El Paso
DepartmentPsychology
Address500 WEST UNIVERSITY
216B Psychology
El Paso TX 79968
Phone9157476566
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    Collapse Overview 
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    Research in Dr. Serafine’s behavioral pharmacology laboratory focuses on the different factors that contribute to individual differences in vulnerability to drug abuse. To investigate these factors, Dr. Serafine uses preclinical models to investigate how factors such as age, sex and diet impact sensitivity to drugs of abuse like cocaine. Drug sensitivity is assessed using behavioral pharmacological models including unconditioned behavior (e.g., locomotion) and more complex behaviors using classical and operant conditioning (e.g., conditioned place preference, drug discrimination, or intravenous self-administration). Students in the laboratory receive hands on training on how to conduct behavioral experiments that help answer important questions about abuse vulnerability. Dr. Serafine’s current research interests include studying how diets high in fat or sugar change individual sensitivity to cocaine and other drugs that act on dopamine systems. Dr. Serafine is also interested in considering differential impact of age, sex and diet on sensitivity to prescription drugs such as antidepressants and drugs used to treat obesity.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Beltran NM, Ramos J, Galindo KI, Echeverri Alegre JI, Cruz B, Hernandez-Casner C, Serafine KM. Intermittent dietary supplementation with fish oil prevents high fat diet-induced enhanced sensitivity to dopaminergic drugs. Behav Pharmacol. 2021 Feb 01; 32(1):9-20. PMID: 33399293.
      Citations:    Fields:    
    2. Charles NE, Strong SJ, Burns LC, Bullerjahn MR, Serafine KM. Increased mood disorder symptoms, perceived stress, and alcohol use among college students during the COVID-19 pandemic. Psychiatry Res. 2021 02; 296:113706. PMID: 33482422.
      Citations:    Fields:    
    3. Ramos J, Hardin EJ, Grant AH, Flores-Robles G, Gonzalez AT, Cruz B, Martinez AK, Beltran NM, Serafine KM. The Effects of Eating a High Fat Diet on Sensitivity of Male and Female Rats to Methamphetamine and Dopamine D1 Receptor Agonist SKF 82958. J Pharmacol Exp Ther. 2020 07; 374(1):6-15. PMID: 32265322.
      Citations:    Fields:    Translation:Animals
    4. Darcey VL, Serafine KM. Omega-3 Fatty Acids and Vulnerability to Addiction: Reviewing Preclinical and Clinical Evidence. Curr Pharm Des. 2020; 26(20):2385-2401. PMID: 32348211.
      Citations:    Fields:    Translation:Humans
    5. Hernandez-Casner C, Woloshchuk CJ, Poisson C, Hussain S, Ramos J, Serafine KM. Dietary supplementation with fish oil reverses high fat diet-induced enhanced sensitivity to the behavioral effects of quinpirole. Behav Pharmacol. 2019 06; 30(4):370-375. PMID: 31085944.
      Citations: 1     Fields:    Translation:Animals
    6. Cruz B, Flores RJ, Uribe KP, Espinoza EJ, Spencer CT, Serafine KM, Nazarian A, O'Dell LE. Insulin modulates the strong reinforcing effects of nicotine and changes in insulin biomarkers in a rodent model of diabetes. Neuropsychopharmacology. 2019 05; 44(6):1141-1151. PMID: 30647447.
      Citations: 2     Fields:    Translation:Animals
    7. Ramos J, Hernandez-Casner C, Cruz B, Serafine KM. Sex differences in high fat diet-induced impairments to striatal Akt signaling and enhanced sensitivity to the behavioral effects of dopamine D2/D3 receptor agonist quinpirole. Physiol Behav. 2019 05 01; 203:25-32. PMID: 29154786.
      Citations: 4     Fields:    Translation:AnimalsCells
    8. Hernandez-Casner C, Ramos J, Serafine KM. Dietary supplementation with fish oil prevents high fat diet-induced enhancement of sensitivity to the behavioral effects of quinpirole. Behav Pharmacol. 2017 09; 28(6):477-484. PMID: 28574870.
      Citations: 2     Fields:    Translation:Animals
    9. Serafine KM, Rice KC, France CP. Characterization of the discriminative stimulus effects of lorcaserin in rats. J Exp Anal Behav. 2016 09; 106(2):107-16. PMID: 27640338.
      Citations: 4     Fields:    Translation:Animals
    10. Serafine KM, Labay C, France CP. Dietary supplementation with fish oil prevents high fat diet-induced enhancement of sensitivity to the locomotor stimulating effects of cocaine in adolescent female rats. Drug Alcohol Depend. 2016 Aug 01; 165:45-52. PMID: 27242289.
      Citations: 6     Fields:    Translation:Animals
    11. Serafine KM, Rice KC, France CP. Directly Observable Behavioral Effects of Lorcaserin in Rats. J Pharmacol Exp Ther. 2015 Dec; 355(3):381-5. PMID: 26384326.
      Citations: 11     Fields:    Translation:Animals
    12. Serafine KM, Bentley TA, Kilborn DJ, Koek W, France CP. Drinking sucrose or saccharin enhances sensitivity of rats to quinpirole-induced yawning. Eur J Pharmacol. 2015 Oct 05; 764:529-536. PMID: 26189020.
      Citations: 1     Fields:    Translation:Animals
    13. Serafine KM, Bentley TA, Koek W, France CP. Eating high fat chow, but not drinking sucrose or saccharin, enhances the development of sensitization to the locomotor effects of cocaine in adolescent female rats. Behav Pharmacol. 2015 Apr; 26(3):321-5. PMID: 25485647.
      Citations: 7     Fields:    Translation:Animals
    14. Serafine KM, Bentley TA, Grenier AE, France CP. Eating high fat chow and the behavioral effects of direct-acting and indirect-acting dopamine receptor agonists in female rats. Behav Pharmacol. 2014 Aug; 25(4):287-95. PMID: 24949571.
      Citations: 7     Fields:    Translation:Animals
    15. Serafine KM, France CP. Restricted access to standard or high fat chow alters sensitivity of rats to the 5-HT(2A/2C) receptor agonist 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane. Behav Pharmacol. 2014 Feb; 25(1):44-52. PMID: 24346289.
      Citations: 4     Fields:    Translation:Animals
    16. Briscione MA, Serafine KM, Merluzzi AP, Rice KC, Riley AL. The effects of the 5-HT3 receptor antagonist tropisetron on cocaine-induced conditioned taste aversions. Pharmacol Biochem Behav. 2013 Apr; 105:112-7. PMID: 23415734.
      Citations: 2     Fields:    Translation:Animals
    17. Serafine KM, Briscione MA, Rice KC, Riley AL. Dopamine mediates cocaine-induced conditioned taste aversions as demonstrated with cross-drug preexposure to GBR 12909. Pharmacol Biochem Behav. 2012 Aug; 102(2):269-74. PMID: 22579912.
      Citations: 4     Fields:    Translation:Animals
    18. Serafine KM, Briscione MA, Riley AL. The effects of haloperidol on cocaine-induced conditioned taste aversions. Physiol Behav. 2012 Mar 20; 105(5):1161-7. PMID: 22212241.
      Citations: 6     Fields:    Translation:Animals
    19. Serafine KM, Riley AL. Preexposure to cocaine attenuates aversions induced by both cocaine and fluoxetine: Implications for the basis of cocaine-induced conditioned taste aversions. Pharmacol Biochem Behav. 2010 Apr; 95(2):230-4. PMID: 20122955.
      Citations: 6     Fields:    Translation:Animals
    20. Serafine KM, Riley AL. Possible role of norepinephrine in cocaine-induced conditioned taste aversions. Pharmacol Biochem Behav. 2009 Mar; 92(1):111-6. PMID: 19027784.
      Citations: 7     Fields:    Translation:Animals
    21. Roma PG, Rinker JA, Serafine KM, Chen SA, Barr CS, Cheng K, Rice KC, Riley AL. Genetic and early environmental contributions to alcohol's aversive and physiological effects. Pharmacol Biochem Behav. 2008 Nov; 91(1):134-9. PMID: 18639579.
      Citations: 6     Fields:    Translation:Animals
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