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Charles T. Spencer

Faculty RankAssistant Professor
InstitutionUniversity of Texas at El Paso
DepartmentBiological Sciences
Address500 W University Ave
Bioscience Research Building 5.148
El Paso TX 79968
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    Collapse Biography 
    Collapse awards and honors
    2012Travel Award for presentation at Immunology 2012, AAI
    2013Professional Development Symposium, ASCB Minority Affairs Committee
    2015 - 2016Faculty Research and Educational Development program, ASCB
    2015Travel Award for presentation at Immunology 2015, AAI
    2016Faculty Research and Educational Development Travel award, ASCB
    2016Travel Award for presentation at Immunology 2016, AAI

    Collapse Overview 
    Collapse overview
    NKT cells are a subset of white blood cells that regulate immune response to bacterial, viral and parasitic infections. They also prevent unwanted immune responses that cause autoimmune diseases such as type I diabetes and multiple sclerosis. Therefore, the objective of the experiments described here is to gain insight into the mechanism(s) by which NKT cells regulate immune responses to infections such as Francisella spp. including Francisella tularensis, F. holarctica, and F. novicida, a relative of F. tularensis which causes tularemic-like disease in mice, Mycobacterium tublerculosis the eitiological agent of tuberculosis, and Listeria monocytogenes (Lm), a common intestinal pathogen that causes food poisoning.

    All of these bacteria survive in cells of the immune system and are thereby protected from much of the immune response. In order to eliminate this infection, small molecules of the immune system called cytokines must be released into the system to activate the cells where these bacteria survive. NKT cells are capable of releasing numerous cytokines as well as causing or preventing the release of cytokines from other cells. Over-production of cytokines is detrimential to the host so fine control over cytokines is necessary for health. NKT cells appear to be central to this level of control.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Portillo C, Adinoff B, Spencer CT, Field CA. The association of allostasis with alcohol use: A case-control study in males with and without alcohol use disorder. Alcohol. 2023 Nov; 112:9-16. PMID: 37454744.
      Citations:    Fields:    
    2. Cruz B, Casta?eda K, Aranda M, Hinojosa CA, Castro-Gutierrez R, Flores RJ, Spencer CT, Vozella V, Roberto M, Gadad BS, Roychowdhury S, O'Dell LE. Alcohol self-administration and nicotine withdrawal alter biomarkers of stress and inflammation and prefrontal cortex changes in G? subunits. Am J Drug Alcohol Abuse. 2023 05 04; 49(3):321-332. PMID: 36206520.
      Citations: 1     Fields:    Translation:Animals
    3. Spencer CT, Ramos Muniz MG, Setzu NR, Sanchez Guillen MA. Francisella tularensis Infection of Mice as a Model of Sepsis. Methods Mol Biol. 2021; 2321:75-100. PMID: 34048009.
      Citations: 1     Fields:    Translation:AnimalsCells
    4. Cleetus CM, Alvarez Primo F, Fregoso G, Lalitha Raveendran N, Noveron JC, Spencer CT, Ramana CV, Joddar B. Alginate Hydrogels with Embedded ZnO Nanoparticles for Wound Healing Therapy. Int J Nanomedicine. 2020; 15:5097-5111. PMID: 32764939.
      Citations: 31     Fields:    Translation:Cells
    5. Cruz B, Flores RJ, Uribe KP, Espinoza EJ, Spencer CT, Serafine KM, Nazarian A, O'Dell LE. Insulin modulates the strong reinforcing effects of nicotine and changes in insulin biomarkers in a rodent model of diabetes. Neuropsychopharmacology. 2019 05; 44(6):1141-1151. PMID: 30647447.
      Citations: 5     Fields:    Translation:Animals
    6. Spencer CT, Vasconcelos JR, Thornburg NJ, Zimmer SL. Advances in Emerging and Neglected Infectious Diseases 2018. Biomed Res Int. 2018; 2018:4619282. PMID: 30112390.
      Citations:    Fields:    Translation:HumansAnimals
    7. Ramos Muniz MG, Palfreeman M, Setzu N, Sanchez MA, Saenz Portillo P, Garza KM, Gosselink KL, Spencer CT. Obesity Exacerbates the Cytokine Storm Elicited by Francisella tularensis Infection of Females and Is Associated with Increased Mortality. Biomed Res Int. 2018; 2018:3412732. PMID: 30046592.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    8. Spencer CT, Vasconcelos JR. Advances in Emerging and Neglected Infectious Diseases. Biomed Res Int. 2017; 2017:1467693. PMID: 28321401.
      Citations:    Fields:    Translation:Humans
    9. Duarte TT, Spencer CT. Personalized Proteomics: The Future of Precision Medicine. Proteomes. 2016; 4(4). PMID: 27882306.
    10. Xia M, Hesser DC, De P, Sakala IG, Spencer CT, Kirkwood JS, Abate G, Chatterjee D, Dobos KM, Hoft DF. A Subset of Protective ?9d2 T Cells Is Activated by Novel Mycobacterial Glycolipid Components. Infect Immun. 2016 09; 84(9):2449-62. PMID: 27297390.
      Citations: 17     Fields:    Translation:AnimalsCells
    11. Nune KC, Somani MC, Spencer CT & Misra RDK. Materials Technology. Cellular response of Staphylococcus aureus to nanostructured metallic biomedical devices: surface binding and mechanism of disruption of colonization. 2016; 1-10. View Publication.
    12. Abate G, Spencer CT, Hamzabegovic F, Blazevic A, Xia M, Hoft DF. Mycobacterium-Specific ?9d2 T Cells Mediate Both Pathogen-Inhibitory and CD40 Ligand-Dependent Antigen Presentation Effects Important for Tuberculosis Immunity. Infect Immun. 2016 02; 84(2):580-9. PMID: 26644385.
      Citations: 10     Fields:    Translation:HumansCells
    13. Spencer CT, Bezbradica JS, Ramos MG, Arico CD, Conant SB, Gilchuk P, Gray JJ, Zheng M, Niu X, Hildebrand W, Link AJ, Joyce S. Viral infection causes a shift in the self peptide repertoire presented by human MHC class I molecules. Proteomics Clin Appl. 2015 Dec; 9(11-12):1035-52. PMID: 26768311.
      Citations: 8     Fields:    Translation:HumansCells
    14. Gilchuk P, Spencer CT, Conant SB, Hill T, Gray JJ, Niu X, Zheng M, Erickson JJ, Boyd KL, McAfee KJ, Oseroff C, Hadrup SR, Bennink JR, Hildebrand W, Edwards KM, Crowe JE, Williams JV, Buus S, Sette A, Schumacher TN, Link AJ, Joyce S. Discovering naturally processed antigenic determinants that confer protective T cell immunity. J Clin Invest. 2013 May; 123(5):1976-87. PMID: 23543059.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    15. Spencer CT, Dragovic SM, Conant SB, Gray JJ, Zheng M, Samir P, Niu X, Moutaftsi M, Van Kaer L, Sette A, Link AJ, Joyce S. Sculpting MHC class II-restricted self and non-self peptidome by the class I Ag-processing machinery and its impact on Th-cell responses. Eur J Immunol. 2013 May; 43(5):1162-72. PMID: 23386199.
      Citations: 6     Fields:    Translation:AnimalsCells
    16. Spencer CT, Abate G, Sakala IG, Xia M, Truscott SM, Eickhoff CS, Linn R, Blazevic A, Metkar SS, Peng G, Froelich CJ, Hoft DF. Granzyme A produced by ?(9)d(2) T cells induces human macrophages to inhibit growth of an intracellular pathogen. PLoS Pathog. 2013 Jan; 9(1):e1003119. PMID: 23326234.
      Citations: 55     Fields:    Translation:HumansCells
    17. Gordy LE, Bezbradica JS, Flyak AI, Spencer CT, Dunkle A, Sun J, Stanic AK, Boothby MR, He YW, Zhao Z, Van Kaer L, Joyce S. IL-15 regulates homeostasis and terminal maturation of NKT cells. J Immunol. 2011 Dec 15; 187(12):6335-45. PMID: 22084435.
      Citations: 98     Fields:    Translation:AnimalsCells
    18. Hoft DF, Babusis E, Worku S, Spencer CT, Lottenbach K, Truscott SM, Abate G, Sakala IG, Edwards KM, Creech CB, Gerber MA, Bernstein DI, Newman F, Graham I, Anderson EL, Belshe RB. Live and inactivated influenza vaccines induce similar humoral responses, but only live vaccines induce diverse T-cell responses in young children. J Infect Dis. 2011 Sep 15; 204(6):845-53. PMID: 21846636.
      Citations: 157     Fields:    Translation:HumansCellsPHPublic Health
    19. Spencer CT, Gilchuk P, Dragovic SM, Joyce S. Minor histocompatibility antigens: presentation principles, recognition logic and the potential for a healing hand. Curr Opin Organ Transplant. 2010 Aug; 15(4):512-25. PMID: 20616723.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    20. Lee K, Gudapati P, Dragovic S, Spencer C, Joyce S, Killeen N, Magnuson MA, Boothby M. Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways. Immunity. 2010 Jun 25; 32(6):743-53. PMID: 20620941.
      Citations: 275     Fields:    Translation:AnimalsCells
    21. Spencer CT, Abate G, Blazevic A, Hoft DF. Only a subset of phosphoantigen-responsive gamma9delta2 T cells mediate protective tuberculosis immunity. J Immunol. 2008 Oct 01; 181(7):4471-84. PMID: 18802050.
      Citations: 60     Fields:    Translation:HumansCells
    22. Hamdouchi C, Zhong B, Mendoza J, Collins E, Jaramillo C, De Diego JE, Robertson D, Spencer CD, Anderson BD, Watkins SA, Zhang F, Brooks HB. Structure-based design of a new class of highly selective aminoimidazo[1,2-a]pyridine-based inhibitors of cyclin dependent kinases. Bioorg Med Chem Lett. 2005 Apr 01; 15(7):1943-7. PMID: 15780638.
      Citations: 5     Fields:    Translation:HumansCells
    23. Zhu G, Conner SE, Zhou X, Shih C, Li T, Anderson BD, Brooks HB, Campbell RM, Considine E, Dempsey JA, Faul MM, Ogg C, Patel B, Schultz RM, Spencer CD, Teicher B, Watkins SA. Synthesis, structure-activity relationship, and biological studies of indolocarbazoles as potent cyclin D1-CDK4 inhibitors. J Med Chem. 2003 May 22; 46(11):2027-30. PMID: 12747775.
      Citations: 17     Fields:    Translation:HumansCells
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    RCMI CC is supported by the National Institute on Minority Health and Health Disparities, National Institutes of Health (NIH), through Grant Number U24MD015970. The contents of this site are solely the responsibility of the authors and do not necessarily represent the official views of the NIH

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