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George Negrete

InstitutionUniversity of Texas at San Antonio
Address1 UTSA Circle
San Antonio TX 78249
Phone(210) 458-5448
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    My laboratory is engaged in two research areas: 1) the preparation of novel, amino-acid derived lipids for diverse applications including experimental antibiotics for human, animal, and plant diseases, and for imbuing lipid nanoparticles with desirable properties for drug delivery; and 2), the synthesis of perylene dyes for biophotonic and photo-harvesting applications. While investigating these topics, my group and I are intensely interested in student training at all levels.

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Betts-Obregon BS, Salinas M, Oladunni D, Negrete GR, Tsin AT. Chemical Modification of Ginsenoside on Cell Viability and Cytokine Secretion. Curr Aging Sci. 2017; 10(1):68-75. PMID: 27659265.
      Citations:    Fields:    Translation:HumansCells
    2. Farooqi MJ, Penick MA, Negrete GR, Brancaleon L. Human serum albumin as vehicle for the solubilization of perylene diimides in aqueous solutions. Int J Biol Macromol. 2017 Jan; 94(Pt A):246-257. PMID: 27720966.
      Citations: 1     Fields:    Translation:HumansCells
    3. Ishikawa AA, Salazar JV, Salinas M, Gaitani CM, Nurkiewicz T, Negrete GR, Garcia CD. Self-Assembled Nanospheres for Encapsulation and Aerosolization of Rifampicin. RSC Adv. 2016 Jan 01; 6(16):12959-12963. PMID: 26998252.
    4. Farooqi MJ, Penick MA, Burch J, Negrete GR, Brancaleon L. Characterization of novel perylene diimides containing aromatic amino acid side chains. Spectrochim Acta A Mol Biomol Spectrosc. 2016 Jan 15; 153:124-31. PMID: 26298679.
      Citations: 1     Fields:    
    5. Mfuh AM, Mahindaratne MP, Yñigez-Gutierrez AE, Ramos Dominguez JR, Bedell JT, Garcia CD, Negrete GR. Acid-responsive nanospheres from an asparagine-derived amphiphile. RSC Adv. 2015; 5:8585-8590. PMID: 25914807.
    6. Farooqi MJ, Penick MA, Negrete GR, Brancaleon L. Interaction of human serum albumin with novel 3,9-disubstituted perylenes. Protein J. 2013 Aug; 32(6):493-504. PMID: 23975144.
      Citations: 3     Fields:    Translation:HumansCells
    7. Chumbimuni-Torres KY, Coronado RE, Mfuh AM, Castro-Guerrero C, Silva MF, Negrete GR, Bizios R, Garcia CD. Adsorption of Proteins to Thin-Films of PDMS and Its Effect on the Adhesion of Human Endothelial Cells. RSC Adv. 2011 Sep 21; 1(4):706-714. PMID: 25068038.
    8. Mfuh AM, Mahindaratne MP, Quintero MV, Lakner FJ, Bao A, Goins BA, Phillips WT, Negrete GR. Novel asparagine-derived lipid enhances distearoylphosphatidylcholine bilayer resistance to acidic conditions. Langmuir. 2011 Apr 19; 27(8):4447-55. PMID: 21413760.
      Citations: 3     Fields:    
    9. Fuini JF, Surampudi AB, Penick MA, Mahindaratne MP, Negrete GR, Brancaleon L. The photophysical Characterisation of Novel 3,9-Dialkyloxy- and Diacyloxyperylenes. Dyes Pigm. 2011 Feb 01; 88(2):204-211. PMID: 25473140.
    10. Smith TD, Mahindaratne MP, Penick MA, Negrete GR, Daniels LM, Tiekink ER. 4,10-Diall-yloxy-1,2,3,6b,7,8,9,12b-octa-hydro-perylene. Acta Crystallogr Sect E Struct Rep Online. 2009 Dec 09; 66(Pt 1):o96. PMID: 21580191.
    11. Kundu SK, Mahindaratne MP, Quinõnes B, Negrete GR, Tiekink ER. (2S,4S)-3-Acryloyl-6-oxo-2-phenyl-perhydro-pyrimidine-4-carboxylic acid. Acta Crystallogr Sect E Struct Rep Online. 2009 Dec 04; 66(Pt 1):o3. PMID: 21580137.
    12. Penick MA, Mahindaratne MP, Gutierrez RD, Smith TD, Tiekink ER, Negrete GR. Tandem Friedel-Crafts annulation to novel perylene analogues. J Org Chem. 2008 Aug 15; 73(16):6378-81. PMID: 18630879.
      Citations: 3     Fields:    Translation:Cells
    13. Zeng X, Negrete GA, Kasmer C, Yang WW, Gearhart PJ. Absence of DNA polymerase eta reveals targeting of C mutations on the nontranscribed strand in immunoglobulin switch regions. J Exp Med. 2004 Apr 05; 199(7):917-24. PMID: 15051760.
      Citations: 31     Fields:    Translation:HumansCells
    14. Bao A, Goins B, Klipper R, Negrete G, Phillips WT. 186Re-liposome labeling using 186Re-SNS/S complexes: in vitro stability, imaging, and biodistribution in rats. J Nucl Med. 2003 Dec; 44(12):1992-9. PMID: 14660726.
      Citations: 23     Fields:    Translation:Animals
    15. Bao A, Goins B, Klipper R, Negrete G, Phillips WT. Direct 99mTc labeling of pegylated liposomal doxorubicin (Doxil) for pharmacokinetic and non-invasive imaging studies. J Pharmacol Exp Ther. 2004 Feb; 308(2):419-25. PMID: 14610219.
      Citations: 29     Fields:    Translation:Animals
    16. Bao A, Goins B, Klipper R, Negrete G, Mahindaratne M, Phillips WT. A novel liposome radiolabeling method using 99mTc-"SNS/S" complexes: in vitro and in vivo evaluation. J Pharm Sci. 2003 Sep; 92(9):1893-904. PMID: 12950007.
      Citations: 19     Fields:    Translation:Animals
    17. Westfall DA, Flores RR, Negrete GR, Martinez AO, Haro LS. High-resolution polyacrylamide gel electrophoresis of carbohydrates derivatized with a visible dye. Anal Biochem. 1998 Dec 15; 265(2):232-7. PMID: 9882397.
      Citations:    Fields:    
    18. Song Q, Negrete GR, Wolfe AR, Wang K, Meehan T. Synthesis and characterization of bay region halohydrins derived from Benzo[a]pyrene diol epoxide and their role as intermediates in halide-catalyzed cis adduct formation. Chem Res Toxicol. 1998 Sep; 11(9):1057-66. PMID: 9760280.
      Citations:    Fields:    Translation:Cells
    19. Meehan T, Wolfe AR, Negrete GR, Song Q. Benzo[a]pyrene diol epoxide-DNA cis adduct formation through a trans chlorohydrin intermediate. Proc Natl Acad Sci U S A. 1997 Mar 04; 94(5):1749-54. PMID: 9050850.
      Citations: 1     Fields:    Translation:Cells
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