"Phosphofructokinase-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An allosteric enzyme that regulates glycolysis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-1,6-bisphosphate. D-tagatose- 6-phosphate and sedoheptulose-7-phosphate also are acceptors. UTP, CTP, and ITP also are donors. In human phosphofructokinase-1, three types of subunits have been identified. They are PHOSPHOFRUCTOKINASE-1, MUSCLE TYPE; PHOSPHOFRUCTOKINASE-1, LIVER TYPE; and PHOSPHOFRUCTOKINASE-1, TYPE C; found in platelets, brain, and other tissues.
| Descriptor ID |
D010732
|
| MeSH Number(s) |
D08.811.913.696.620.225.850.500
|
| Concept/Terms |
Phosphofructokinase-1- Phosphofructokinase-1
- Phosphofructokinase 1
- 6-Phosphofructokinase
- 6 Phosphofructokinase
- Fructose-6-phosphate 1-Phosphotransferase
- 6-Phosphofructo-1-kinase
- Fructose-6-P 1-Kinase
|
Below are MeSH descriptors whose meaning is more general than "Phosphofructokinase-1".
Below are MeSH descriptors whose meaning is more specific than "Phosphofructokinase-1".
This graph shows the total number of publications written about "Phosphofructokinase-1" by people in this website by year, and whether "Phosphofructokinase-1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 1995 | 3 | 0 | 3 |
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Below are the most recent publications written about "Phosphofructokinase-1" by people in Profiles.
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Auzat I, Byrnes WM, Garel JR, Chang SH. Role of residue 161 in the allosteric transitions of two bacterial phosphofructokinases. Biochemistry. 1995 May 30; 34(21):7062-8.
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Zhu X, Byrnes M, Nelson JW, Chang SH. Role of glycine 212 in the allosteric behavior of phosphofructokinase from Bacillus stearothermophilus. Biochemistry. 1995 Feb 28; 34(8):2560-5.
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Byrnes WM, Hu W, Younathan ES, Chang SH. A chimeric bacterial phosphofructokinase exhibits cooperativity in the absence of heterotropic regulation. J Biol Chem. 1995 Feb 24; 270(8):3828-35.
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Byrnes M, Zhu X, Younathan ES, Chang SH. Kinetic characteristics of phosphofructokinase from Bacillus stearothermophilus: MgATP nonallosterically inhibits the enzyme. Biochemistry. 1994 Mar 22; 33(11):3424-31.
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Li J, Zhu X, Byrnes M, Nelson JW, Chang SH. Site-directed mutagenesis of rabbit muscle phosphofructokinase cDNA. Mutations at glutamine 200 affect the allosteric properties of the enzyme. J Biol Chem. 1993 Nov 25; 268(33):24599-606.
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Li J, Chen Z, Lu L, Byrnes M, Chang SH. Sequence diversity in the 5' untranslated region of rabbit muscle phosphofructokinase mRNA. Biochem Biophys Res Commun. 1990 Aug 16; 170(3):1056-60.