Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux.

Lee RE, Hurdle JG, Liu J, Bruhn DF, Matt T, Scherman MS, Vaddady PK, Zheng Z, Qi J, Akbergenov R, Das S, Madhura DB, Rathi C, Trivedi A, Villellas C, Lee RB, Waidyarachchi SL, Sun D, McNeil MR, Ainsa JA, Boshoff HI, Gonzalez-Juarrero M, Meibohm B, B?ttger EC, Lenaerts AJ. Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux. Nat Med. 2014 Feb; 20(2):152-158.

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subject areas

Amides
Animals
Antitubercular Agents
ATP-Binding Cassette Transporters
Bacterial Proteins
Drug Design
Drug Resistance, Multiple, Bacterial
Mice
Models, Molecular
Mycobacterium tuberculosis
Ribosomes
Spectinomycin
Structure-Activity Relationship
Tuberculosis, Multidrug-Resistant

authors with profiles

Dianqing Sun, PhD

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