"Hemicholinium 3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A potent inhibitor of the high affinity uptake system for CHOLINE. It has less effect on the low affinity uptake system. Since choline is one of the components of ACETYLCHOLINE, treatment with hemicholinium can deplete acetylcholine from cholinergic terminals. Hemicholinium 3 is commonly used as a research tool in animal and in vitro experiments.
| Descriptor ID |
D006426
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| MeSH Number(s) |
D02.092.877.435 D02.675.276.435
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Hemicholinium 3".
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This graph shows the total number of publications written about "Hemicholinium 3" by people in this website by year, and whether "Hemicholinium 3" was a major or minor topic of these publications.
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Below are the most recent publications written about "Hemicholinium 3" by people in Profiles.
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Ivy MT, Newkirk RF, Wang Y, Townsel JG. A novel choline cotransporter sequestration compartment in cholinergic neurons revealed by selective endosomal ablation. J Neurochem. 2010 Mar; 112(5):1295-304.
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Ivy MT, Newkirk RF, Karim MR, Mtshali CM, Townsel JG. Hemicholinium-3 mustard reveals two populations of cycling choline cotransporters in Limulus. Neuroscience. 2001; 102(4):969-78.
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Ford BD, Ivy MT, Mtshali CP, Townsel JG. The involvement of protein kinase C in the regulation of choline cotransport in Limulus. Comp Biochem Physiol A Mol Integr Physiol. 1999 Jul; 123(3):255-61.
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Torrence-Campbell C, Gates H, Effiong U, Sweet S, Townsel JG. An improved invertebrate synaptosomal preparation with cholinergic properties. J Neurosci Methods. 1991 Jul; 38(2-3):161-9.
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Ivy MT, Townsel JG. A comparative study of high affinity choline uptake and choline utilization in cholinergic and non-cholinergic tissues. Comp Biochem Physiol C Comp Pharmacol Toxicol. 1987; 86(1):111-20.
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Ivy MT, Sukumar R, Townsel JG. The characterization of a sodium-dependent high affinity choline uptake system unassociated with acetylcholine biosynthesis. Comp Biochem Physiol C Comp Pharmacol Toxicol. 1985; 81(2):351-7.