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Mitchell B Schaffler, PhD

TitleProfessor
Faculty RankProfessor
InstitutionCity College, CUNY
DepartmentBiomedical Engineering
Address160 Convent Ave
New York NY 10031
Phone+12126505070
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    R29AR041210     (SCHAFFLER, MITCHELL B)Sep 15, 1992 - Aug 31, 1997
    NIH
    MICRODAMAGE AND BONE REMODELING IN STRESS FRACTURE
    Role: Principal Investigator
    R01AR041210     (SCHAFFLER, MITCHELL B)Sep 15, 1992 - Feb 28, 2021
    NIH
    Ostecocyte Intergrity and Bone Remodeling
    Role: Principal Investigator
    R01AR057139     (WEINBAUM, SHELDON)Sep 6, 2010 - Aug 31, 2016
    NIH
    Structural, Molecular, and Functional Specialization in Osteocyte Mechanosensing
    Role: Co-Principal Investigator
    R21AR060445     (SCHAFFLER, MITCHELL B)Jan 1, 2011 - Dec 31, 2013
    NIH
    Diffuse microdamage in bone: Direct repair without remodeling
    Role: Principal Investigator
    R01AR070547     (SCHAFFLER, MITCHELL B ;SPRAY, DAVID C)Jul 11, 2018 - Apr 30, 2024
    NIH
    Structural, Molecular and Functional Specialization in Osteocyte Mechanosensing
    Role: Principal Investigator
    R01AG056397     (SCHAFFLER, MITCHELL B;YAKAR, SHOSHANA)Sep 15, 2018 - Apr 30, 2024
    NIH
    Diverse effects of somatopause and aging on the skeleton
    Role: Principal Investigator
    R01AR081381     (SCHAFFLER, MITCHELL B)Sep 5, 2023 - Mar 31, 2029
    NIH
    Renewed bone remodeling after pausing long-term bisphosphonate use: Does it replace regions of impaired bone quality and restore mechanical integrity?
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Poudel SB, Ruff RR, He Z, Dixit M, Yildirim G, Jayarathne H, Manchanayake DH, Basta-Pljakic J, Duran-Ortiz S, Schaffler MB, Kopchick JJ, Sadagurski M, Yakar S. The impact of inactivation of the GH/IGF axis during aging on healthspan. Geroscience. 2025 Jun; 47(3):3027-3042. PMID: 39535693.
      Citations: 1     Fields:    Translation:Animals
    2. Poudel SB, Frikha-Benayed D, Ruff RR, Yildirim G, Dixit M, Korstanje R, Robinson L, Miller RA, Harrison DE, Strong JR, Schaffler MB, Yakar S. Targeting mitochondrial dysfunction using methylene blue or mitoquinone to improve skeletal aging. Aging (Albany NY). 2024 03 25; 16(6):4948-4964. PMID: 38535998.
      Citations: 2     Fields:    Translation:Animals
    3. Lewis KJ, Boorman-Padgett JF, Castaneda M, Spray DC, Thi MM, Schaffler MB. A Fluorescent Intravital Imaging Approach to Study Load-Induced Calcium Signaling Dynamics in Mouse Osteocytes. J Vis Exp. 2023 02 24; (192). PMID: 36912542.
      Citations: 3     Fields:    Translation:AnimalsCells
    4. Dixit M, Louis LD, Basta-Pljakic J, Yildirim G, Poudel SB, Kumararaja F, List EO, Duran SO, Kopchick JJ, Ruff RR, Schaffler MB, Yakar S. Lifelong Excess in GH Elicits Sexually Dimorphic Effects on Skeletal Morphology and Bone Mechanical Properties. J Bone Miner Res. 2022 11; 37(11):2201-2214. PMID: 36069368.
      Citations: 1     Fields:    Translation:Animals
    5. Dixit M, Duran-Ortiz S, Yildirim G, Poudel SB, Louis LD, Bartke A, Schaffler MB, Kopchick JJ, Yakar S. Induction of somatopause in adult mice compromises bone morphology and exacerbates bone loss during aging. Aging Cell. 2021 12; 20(12):e13505. PMID: 34811875.
      Citations: 7     Fields:    Translation:Animals
    6. Lewis KJ, Cabahug-Zuckerman P, Boorman-Padgett JF, Basta-Pljakic J, Louie J, Stephen S, Spray DC, Thi MM, Seref-Ferlengez Z, Majeska RJ, Weinbaum S, Schaffler MB. Estrogen depletion on In vivo osteocyte calcium signaling responses to mechanical loading. Bone. 2021 11; 152:116072. PMID: 34171514.
      Citations: 14     Fields:    Translation:AnimalsCells
    7. Coffman AA, Basta-Pljakic J, Guerra RM, Ebetino FH, Lundy MW, Majeska RJ, Schaffler MB. Reply to: A Bisphosphonate With a Low Hydroxyapatite Binding Affinity Prevents Bone Loss in Mice After Ovariectomy and Reverses Rapidly With Treatment Cessation. JBMR Plus. 2021 Jul; 5(7):e10492. PMID: 34258501.
      Citations:    
    8. Dixit M, Liu Z, Poudel SB, Yildirim G, Zhang YZ, Mehta S, Murik O, Altarescu G, Kobayashi Y, Shimizu E, Schaffler MB, Yakar S. Skeletal Response to Insulin in the Naturally Occurring Type 1 Diabetes Mellitus Mouse Model. JBMR Plus. 2021 May; 5(5):e10483. PMID: 33977201.
      Citations:    
    9. Coffman AA, Basta-Pljakic J, Guerra RM, Ebetino FH, Lundy MW, Majeska RJ, Schaffler MB. A Bisphosphonate With a Low Hydroxyapatite Binding Affinity Prevents Bone Loss in Mice After Ovariectomy and Reverses Rapidly With Treatment Cessation. JBMR Plus. 2021 Apr; 5(4):e10476. PMID: 33869992.
      Citations:    
    10. McCutcheon S, Majeska RJ, Spray DC, Schaffler MB, Vazquez M. Apoptotic Osteocytes Induce RANKL Production in Bystanders via Purinergic Signaling and Activation of Pannexin Channels. J Bone Miner Res. 2020 05; 35(5):966-977. PMID: 31910292.
      Citations: 23     Fields:    Translation:AnimalsCells
    11. He Z, Leong DJ, Xu L, Hardin JA, Majeska RJ, Schaffler MB, Thi MM, Yang L, Goldring MB, Cobelli NJ, Sun HB. CITED2 mediates the cross-talk between mechanical loading and IL-4 to promote chondroprotection. Ann N Y Acad Sci. 2019 04; 1442(1):128-137. PMID: 30891766.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    12. Leong DJ, Choudhury M, Hanstein R, Hirsh DM, Kim SJ, Majeska RJ, Schaffler MB, Hardin JA, Spray DC, Goldring MB, Cobelli NJ, Sun HB. Correction to: Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse posttraumatic osteoarthritis model. Arthritis Res Ther. 2019 Jan 03; 21(1):1. PMID: 30606217.
      Citations: 3     Fields:    
    13. Liu Z, Solesio ME, Schaffler MB, Frikha-Benayed D, Rosen CJ, Werner H, Kopchick JJ, Pavlov EV, Abramov AY, Yakar S. Mitochondrial Function Is Compromised in Cortical Bone Osteocytes of Long-Lived Growth Hormone Receptor Null Mice. J Bone Miner Res. 2019 01; 34(1):106-122. PMID: 30216544.
      Citations: 27     Fields:    Translation:AnimalsCells
    14. Seref-Ferlengez Z, Urban-Maldonado M, Sun HB, Schaffler MB, Suadicani SO, Thi MM. Role of pannexin 1 channels in load-induced skeletal response. Ann N Y Acad Sci. 2019 04; 1442(1):79-90. PMID: 29952014.
      Citations: 10     Fields:    Translation:AnimalsCells
    15. Cabahug-Zuckerman P, Stout RF, Majeska RJ, Thi MM, Spray DC, Weinbaum S, Schaffler MB. Potential role for a specialized ?3 integrin-based structure on osteocyte processes in bone mechanosensation. J Orthop Res. 2018 02; 36(2):642-652. PMID: 29087614.
      Citations: 38     Fields:    Translation:AnimalsCells
    16. Liu Z, Han T, Werner H, Rosen CJ, Schaffler MB, Yakar S. Reduced Serum IGF-1 Associated With Hepatic Osteodystrophy Is a Main Determinant of Low Cortical but Not Trabecular Bone Mass. J Bone Miner Res. 2018 01; 33(1):123-136. PMID: 28902430.
      Citations: 21     Fields:    Translation:AnimalsCells
    17. Lewis KJ, Frikha-Benayed D, Louie J, Stephen S, Spray DC, Thi MM, Seref-Ferlengez Z, Majeska RJ, Weinbaum S, Schaffler MB. Osteocyte calcium signals encode strain magnitude and loading frequency in vivo. Proc Natl Acad Sci U S A. 2017 10 31; 114(44):11775-11780. PMID: 29078317.
      Citations: 52     Fields:    Translation:AnimalsCells
    18. McCutcheon S, Majeska R, Schaffler M, Vazquez M. A multiscale fluidic device for the study of dendrite-mediated cell to cell communication. Biomed Microdevices. 2017 Aug 08; 19(3):71. PMID: 28791515.
      Citations: 5     Fields:    Translation:Cells
    19. Liu Z, Han T, Fishman S, Butler J, Zimmermann T, Tremblay F, Harbison C, Agrawal N, Kopchick JJ, Schaffler MB, Yakar S. Ablation of Hepatic Production of the Acid-Labile Subunit in Bovine-GH Transgenic Mice: Effects on Organ and Skeletal Growth. Endocrinology. 2017 08 01; 158(8):2556-2571. PMID: 28475811.
      Citations: 7     Fields:    Translation:AnimalsCells
    20. Kaya S, Basta-Pljakic J, Seref-Ferlengez Z, Majeska RJ, Cardoso L, Bromage TG, Zhang Q, Flach CR, Mendelsohn R, Yakar S, Fritton SP, Schaffler MB. Lactation-Induced Changes in the Volume of Osteocyte Lacunar-Canalicular Space Alter Mechanical Properties in Cortical Bone Tissue. J Bone Miner Res. 2017 04; 32(4):688-697. PMID: 27859586.
      Citations: 57     Fields:    Translation:AnimalsCells
    21. Kennedy OD, Lendhey M, Mauer P, Philip A, Basta-Pljakic J, Schaffler MB. Microdamage induced by in vivo Reference Point Indentation in mice is repaired by osteocyte-apoptosis mediated remodeling. Bone. 2017 02; 95:192-198. PMID: 27919734.
      Citations: 8     Fields:    Translation:AnimalsCells
    22. Dolan EB, Tallon D, Cheung WY, Schaffler MB, Kennedy OD, McNamara LM. Thermally induced osteocyte damage initiates pro-osteoclastogenic gene expression in vivo. J R Soc Interface. 2016 06; 13(119). PMID: 27335224.
      Citations:    Fields:    Translation:AnimalsCells
    23. Frikha-Benayed D, Basta-Pljakic J, Majeska RJ, Schaffler MB. Regional differences in oxidative metabolism and mitochondrial activity among cortical bone osteocytes. Bone. 2016 09; 90:15-22. PMID: 27260646.
      Citations: 22     Fields:    Translation:AnimalsCells
    24. Seref-Ferlengez Z, Maung S, Schaffler MB, Spray DC, Suadicani SO, Thi MM. P2X7R-Panx1 Complex Impairs Bone Mechanosignaling under High Glucose Levels Associated with Type-1 Diabetes. PLoS One. 2016; 11(5):e0155107. PMID: 27159053.
      Citations: 37     Fields:    Translation:AnimalsCells
    25. Cabahug-Zuckerman P, Frikha-Benayed D, Majeska RJ, Tuthill A, Yakar S, Judex S, Schaffler MB. Osteocyte Apoptosis Caused by Hindlimb Unloading is Required to Trigger Osteocyte RANKL Production and Subsequent Resorption of Cortical and Trabecular Bone in Mice Femurs. J Bone Miner Res. 2016 07; 31(7):1356-65. PMID: 26852281.
      Citations: 94     Fields:    Translation:AnimalsCells
    26. Cheung WY, Fritton JC, Morgan SA, Seref-Ferlengez Z, Basta-Pljakic J, Thi MM, Suadicani SO, Spray DC, Majeska RJ, Schaffler MB. Pannexin-1 and P2X7-Receptor Are Required for Apoptotic Osteocytes in Fatigued Bone to Trigger RANKL Production in Neighboring Bystander Osteocytes. J Bone Miner Res. 2016 Apr; 31(4):890-9. PMID: 26553756.
      Citations: 49     Fields:    Translation:AnimalsCells
    27. Liu Z, Kennedy OD, Cardoso L, Basta-Pljakic J, Partridge NC, Schaffler MB, Rosen CJ, Yakar S. DMP-1-mediated Ghr gene recombination compromises skeletal development and impairs skeletal response to intermittent PTH. FASEB J. 2016 Feb; 30(2):635-52. PMID: 26481310.
      Citations: 20     Fields:    Translation:AnimalsCells
    28. Smaldone S, Clayton NP, del Solar M, Pascual G, Cheng SH, Wentworth BM, Schaffler MB, Ramirez F. Fibrillin-1 Regulates Skeletal Stem Cell Differentiation by Modulating TGF? Activity Within the Marrow Niche. J Bone Miner Res. 2016 Jan; 31(1):86-97. PMID: 26189658.
      Citations: 30     Fields:    Translation:AnimalsCells
    29. Seref-Ferlengez Z, Kennedy OD, Schaffler MB. Bone microdamage, remodeling and bone fragility: how much damage is too much damage? Bonekey Rep. 2015; 4:644. PMID: 25848533.
      Citations:    
    30. Cardoso L, Schaffler MB. Changes of elastic constants and anisotropy patterns in trabecular bone during disuse-induced bone loss assessed by poroelastic ultrasound. J Biomech Eng. 2015 Jan; 137(1). PMID: 25412022.
      Citations: 1     Fields:    Translation:Animals
    31. Leong DJ, Choudhury M, Hanstein R, Hirsh DM, Kim SJ, Majeska RJ, Schaffler MB, Hardin JA, Spray DC, Goldring MB, Cobelli NJ, Sun HB. Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse post-traumatic osteoarthritis model. Arthritis Res Ther. 2014 Dec 17; 16(6):508. PMID: 25516005.
      Citations: 40     Fields:    Translation:AnimalsCells
    32. Seref-Ferlengez Z, Basta-Pljakic J, Kennedy OD, Philemon CJ, Schaffler MB. Structural and mechanical repair of diffuse damage in cortical bone in vivo. J Bone Miner Res. 2014 Dec; 29(12):2537-44. PMID: 25042459.
      Citations: 31     Fields:    Translation:Animals
    33. Coughlin TR, Voisin M, Schaffler MB, Niebur GL, McNamara LM. Primary cilia exist in a small fraction of cells in trabecular bone and marrow. Calcif Tissue Int. 2015 Jan; 96(1):65-72. PMID: 25398598.
      Citations: 14     Fields:    Translation:AnimalsCells
    34. Cheung WY, Kennedy OD, Majeska RJ, Schaffler MB. Authors response to letter from Plotkin and Bellido. Calcif Tissue Int. 2014 Oct; 95(4):384. PMID: 25108470.
      Citations:    Fields:    Translation:HumansAnimalsCells
    35. Andarawis-Puri N, Philip A, Laudier D, Schaffler MB, Flatow EL. Temporal effect of in vivo tendon fatigue loading on the apoptotic response explained in the context of number of fatigue loading cycles and initial damage parameters. J Orthop Res. 2014 Sep; 32(9):1097-103. PMID: 24838769.
      Citations: 20     Fields:    Translation:Animals
    36. Kennedy OD, Laudier DM, Majeska RJ, Sun HB, Schaffler MB. Osteocyte apoptosis is required for production of osteoclastogenic signals following bone fatigue in vivo. Bone. 2014 Jul; 64:132-7. PMID: 24709687.
      Citations: 84     Fields:    Translation:AnimalsCells
    37. Kennedy OD, Sun H, Wu Y, Courtland HW, Williams GA, Cardoso L, Basta-Pljakic J, Schaffler MB, Yakar S. Skeletal response of male mice to anabolic hormone therapy in the absence of the Igfals gene. Endocrinology. 2014 Mar; 155(3):987-99. PMID: 24424061.
      Citations: 3     Fields:    Translation:AnimalsCells
    38. Gong Z, Kennedy O, Sun H, Wu Y, Williams GA, Klein L, Cardoso L, Matheny RW, Hubbard GB, Ikeno Y, Farrar RP, Schaffler MB, Adamo ML, Muzumdar RH, Yakar S. Reductions in serum IGF-1 during aging impair health span. Aging Cell. 2014 Jun; 13(3):408-18. PMID: 24341939.
      Citations: 46     Fields:    Translation:Animals
    39. Thi MM, Suadicani SO, Schaffler MB, Weinbaum S, Spray DC. Mechanosensory responses of osteocytes to physiological forces occur along processes and not cell body and require aV?3 integrin. Proc Natl Acad Sci U S A. 2013 Dec 24; 110(52):21012-7. PMID: 24324138.
      Citations: 74     Fields:    Translation:AnimalsCells
    40. Schaffler MB, Cheung WY, Majeska R, Kennedy O. Osteocytes: master orchestrators of bone. Calcif Tissue Int. 2014 Jan; 94(1):5-24. PMID: 24042263.
      Citations: 233     Fields:    Translation:HumansAnimalsCells
    41. Wu Y, Sun H, Basta-Pljakic J, Cardoso L, Kennedy OD, Jasper H, Domen? H, Karabatas L, Guida C, Schaffler MB, Rosen CJ, Yakar S. Serum IGF-1 is insufficient to restore skeletal size in the total absence of the growth hormone receptor. J Bone Miner Res. 2013 Jul; 28(7):1575-86. PMID: 23456957.
      Citations: 23     Fields:    Translation:HumansAnimals
    42. Wu D, Schaffler MB, Weinbaum S, Spray DC. Matrix-dependent adhesion mediates network responses to physiological stimulation of the osteocyte cell process. Proc Natl Acad Sci U S A. 2013 Jul 16; 110(29):12096-101. PMID: 23818616.
      Citations: 24     Fields:    Translation:AnimalsCells
    43. Kennedy OD, Schaffler MB. The roles of osteocyte signaling in bone. J Am Acad Orthop Surg. 2012 Oct; 20(10):670-1. PMID: 23027697.
      Citations: 6     Fields:    Translation:HumansCells
    44. Courtland HW, Kennedy OD, Wu Y, Gao Y, Sun H, Schaffler MB, Yakar S. Low levels of plasma IGF-1 inhibit intracortical bone remodeling during aging. Age (Dordr). 2013 Oct; 35(5):1691-703. PMID: 22976122.
      Citations: 11     Fields:    Translation:AnimalsCells
    45. Schaffler MB, Kennedy OD. Osteocyte signaling in bone. Curr Osteoporos Rep. 2012 Jun; 10(2):118-25. PMID: 22552701.
      Citations: 94     Fields:    Translation:HumansAnimalsCells
    46. Kennedy OD, Herman BC, Laudier DM, Majeska RJ, Sun HB, Schaffler MB. Activation of resorption in fatigue-loaded bone involves both apoptosis and active pro-osteoclastogenic signaling by distinct osteocyte populations. Bone. 2012 May; 50(5):1115-22. PMID: 22342796.
      Citations: 134     Fields:    Translation:AnimalsCells
    47. Lynch ME, Main RP, Xu Q, Schmicker TL, Schaffler MB, Wright TM, van der Meulen MC. Tibial compression is anabolic in the adult mouse skeleton despite reduced responsiveness with aging. Bone. 2011 Sep; 49(3):439-46. PMID: 21642027.
      Citations: 69     Fields:    Translation:Animals
    48. Arteaga-Solis E, Sui-Arteaga L, Kim M, Schaffler MB, Jepsen KJ, Pleshko N, Ramirez F. Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils. Matrix Biol. 2011 Apr; 30(3):188-94. PMID: 21440062.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    49. Lee JY, Zhou Z, Taub PJ, Ramcharan M, Li Y, Akinbiyi T, Maharam ER, Leong DJ, Laudier DM, Ruike T, Torina PJ, Zaidi M, Majeska RJ, Schaffler MB, Flatow EL, Sun HB. BMP-12 treatment of adult mesenchymal stem cells in vitro augments tendon-like tissue formation and defect repair in vivo. PLoS One. 2011 Mar 11; 6(3):e17531. PMID: 21412429.
      Citations: 88     Fields:    Translation:AnimalsCells
    50. Sun HB, Andarawis-Puri N, Li Y, Fung DT, Lee JY, Wang VM, Basta-Pljakic J, Leong DJ, Sereysky JB, Ros SJ, Klug RA, Braman J, Schaffler MB, Jepsen KJ, Flatow EL. Cycle-dependent matrix remodeling gene expression response in fatigue-loaded rat patellar tendons. J Orthop Res. 2010 Oct; 28(10):1380-6. PMID: 20839322.
      Citations: 21     Fields:    Translation:Animals
    51. Zhou Z, Akinbiyi T, Xu L, Ramcharan M, Leong DJ, Ros SJ, Colvin AC, Schaffler MB, Majeska RJ, Flatow EL, Sun HB. Tendon-derived stem/progenitor cell aging: defective self-renewal and altered fate. Aging Cell. 2010 Oct; 9(5):911-5. PMID: 20569237.
      Citations: 112     Fields:    Translation:AnimalsCells
    52. Leong DJ, Li YH, Gu XI, Sun L, Zhou Z, Nasser P, Laudier DM, Iqbal J, Majeska RJ, Schaffler MB, Goldring MB, Cardoso L, Zaidi M, Sun HB. Physiological loading of joints prevents cartilage degradation through CITED2. FASEB J. 2011 Jan; 25(1):182-91. PMID: 20826544.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    53. Lynch ME, Main RP, Xu Q, Walsh DJ, Schaffler MB, Wright TM, van der Meulen MC. Cancellous bone adaptation to tibial compression is not sex dependent in growing mice. J Appl Physiol (1985). 2010 Sep; 109(3):685-91. PMID: 20576844.
      Citations: 59     Fields:    Translation:Animals
    54. Fung DT, Sereysky JB, Basta-Pljakic J, Laudier DM, Huq R, Jepsen KJ, Schaffler MB, Flatow EL. Second harmonic generation imaging and Fourier transform spectral analysis reveal damage in fatigue-loaded tendons. Ann Biomed Eng. 2010 May; 38(5):1741-51. PMID: 20232150.
      Citations: 26     Fields:    Translation:Animals
    55. Leong DJ, Gu XI, Li Y, Lee JY, Laudier DM, Majeska RJ, Schaffler MB, Cardoso L, Sun HB. Matrix metalloproteinase-3 in articular cartilage is upregulated by joint immobilization and suppressed by passive joint motion. Matrix Biol. 2010 Jun; 29(5):420-6. PMID: 20153826.
      Citations: 37     Fields:    Translation:Animals
    56. Fritton JC, Emerton KB, Sun H, Kawashima Y, Mejia W, Wu Y, Rosen CJ, Panus D, Bouxsein M, Majeska RJ, Schaffler MB, Yakar S. Growth hormone protects against ovariectomy-induced bone loss in states of low circulating insulin-like growth factor (IGF-1). J Bone Miner Res. 2010 Feb; 25(2):235-46. PMID: 19619004.
      Citations: 16     Fields:    Translation:AnimalsCells
    57. Gu XI, Leong DJ, Guzman F, Mahamud R, Li YH, Majeska RJ, Schaffler MB, Sun HB, Cardoso L. Development and validation of a motion and loading system for a rat knee joint in vivo. Ann Biomed Eng. 2010 Mar; 38(3):621-31. PMID: 20013312.
      Citations: 8     Fields:    Translation:Animals
    58. Sun Q, Silva EA, Wang A, Fritton JC, Mooney DJ, Schaffler MB, Grossman PM, Rajagopalan S. Sustained release of multiple growth factors from injectable polymeric system as a novel therapeutic approach towards angiogenesis. Pharm Res. 2010 Feb; 27(2):264-71. PMID: 19953308.
      Citations: 51     Fields:    Translation:Animals
    59. Fung DT, Wang VM, Andarawis-Puri N, Basta-Pljakic J, Li Y, Laudier DM, Sun HB, Jepsen KJ, Schaffler MB, Flatow EL. Early response to tendon fatigue damage accumulation in a novel in vivo model. J Biomech. 2010 Jan 19; 43(2):274-9. PMID: 19939387.
      Citations: 66     Fields:    Translation:AnimalsCells
    60. Li W, You L, Schaffler MB, Wang L. The dependency of solute diffusion on molecular weight and shape in intact bone. Bone. 2009 Nov; 45(5):1017-23. PMID: 19647808.
      Citations: 21     Fields:    Translation:AnimalsCells
    61. Cardoso L, Herman BC, Verborgt O, Laudier D, Majeska RJ, Schaffler MB. Osteocyte apoptosis controls activation of intracortical resorption in response to bone fatigue. J Bone Miner Res. 2009 Apr; 24(4):597-605. PMID: 19049324.
      Citations: 146     Fields:    Translation:AnimalsCells
    62. Fung DT, Wang VM, Laudier DM, Shine JH, Basta-Pljakic J, Jepsen KJ, Schaffler MB, Flatow EL. Subrupture tendon fatigue damage. J Orthop Res. 2009 Feb; 27(2):264-273. PMID: 18683881.
      Citations: 66     Fields:    Translation:AnimalsCells
    63. Boskey AL, Gelb BD, Pourmand E, Kudrashov V, Doty SB, Spevak L, Schaffler MB. Ablation of cathepsin k activity in the young mouse causes hypermineralization of long bone and growth plates. Calcif Tissue Int. 2009 Mar; 84(3):229-39. PMID: 19172215.
      Citations: 11     Fields:    Translation:Animals
    64. Kawashima Y, Fritton JC, Yakar S, Epstein S, Schaffler MB, Jepsen KJ, LeRoith D. Type 2 diabetic mice demonstrate slender long bones with increased fragility secondary to increased osteoclastogenesis. Bone. 2009 Apr; 44(4):648-55. PMID: 19150422.
      Citations: 49     Fields:    Translation:AnimalsCells
    65. Yakar S, Rosen CJ, Bouxsein ML, Sun H, Mejia W, Kawashima Y, Wu Y, Emerton K, Williams V, Jepsen K, Schaffler MB, Majeska RJ, Gavrilova O, Gutierrez M, Hwang D, Pennisi P, Frystyk J, Boisclair Y, Pintar J, Jasper H, Domene H, Cohen P, Clemmons D, LeRoith D. Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism. FASEB J. 2009 Mar; 23(3):709-19. PMID: 18952711.
      Citations: 63     Fields:    Translation:AnimalsCells
    66. Wiren KM, Semirale AA, Zhang XW, Woo A, Tommasini SM, Price C, Schaffler MB, Jepsen KJ. Targeting of androgen receptor in bone reveals a lack of androgen anabolic action and inhibition of osteogenesis: a model for compartment-specific androgen action in the skeleton. Bone. 2008 Sep; 43(3):440-51. PMID: 18595795.
      Citations: 28     Fields:    Translation:AnimalsCells
    67. Sun HB, Li Y, Fung DT, Majeska RJ, Schaffler MB, Flatow EL. Coordinate regulation of IL-1beta and MMP-13 in rat tendons following subrupture fatigue damage. Clin Orthop Relat Res. 2008 Jul; 466(7):1555-61. PMID: 18470577.
      Citations: 56     Fields:    Translation:Animals
    68. Choi BG, Vilahur G, Zafar MU, Cardoso L, Yadegar D, Ibanez B, Tunstead J, Viles-Gonzalez JF, Schaffler MB, Fuster V, Badimon JJ. Selective estrogen receptor modulation influences atherosclerotic plaque composition in a rabbit menopause model. Atherosclerosis. 2008 Nov; 201(1):76-84. PMID: 18367192.
      Citations: 6     Fields:    Translation:Animals
    69. Wang Y, McNamara LM, Schaffler MB, Weinbaum S. A model for the role of integrins in flow induced mechanotransduction in osteocytes. Proc Natl Acad Sci U S A. 2007 Oct 02; 104(40):15941-6. PMID: 17895377.
      Citations: 114     Fields:    Translation:AnimalsCells
    70. Mosig RA, Dowling O, DiFeo A, Ramirez MC, Parker IC, Abe E, Diouri J, Aqeel AA, Wylie JD, Oblander SA, Madri J, Bianco P, Apte SS, Zaidi M, Doty SB, Majeska RJ, Schaffler MB, Martignetti JA. Loss of MMP-2 disrupts skeletal and craniofacial development and results in decreased bone mineralization, joint erosion and defects in osteoblast and osteoclast growth. Hum Mol Genet. 2007 May 01; 16(9):1113-23. PMID: 17400654.
      Citations: 94     Fields:    Translation:HumansAnimalsCells
    71. Laudier D, Schaffler MB, Flatow EL, Wang VM. Novel procedure for high-fidelity tendon histology. J Orthop Res. 2007 Mar; 25(3):390-5. PMID: 17149746.
      Citations: 28     Fields:    Translation:Animals
    72. Xiang Y, Yingling VR, Malique R, Li CY, Schaffler MB, Raphan T. Comparative assessment of bone mass and structure using texture-based and histomorphometric analyses. Bone. 2007 Feb; 40(2):544-52. PMID: 17049942.
      Citations: 5     Fields:    Translation:Animals
    73. Yingling VR, Xiang Y, Raphan T, Schaffler MB, Koser K, Malique R. The effect of a short-term delay of puberty on trabecular bone mass and structure in female rats: a texture-based and histomorphometric analysis. Bone. 2007 Feb; 40(2):419-24. PMID: 16979963.
      Citations: 7     Fields:    Translation:Animals
    74. Li CY, Jepsen KJ, Majeska RJ, Zhang J, Ni R, Gelb BD, Schaffler MB. Mice lacking cathepsin K maintain bone remodeling but develop bone fragility despite high bone mass. J Bone Miner Res. 2006 Jun; 21(6):865-75. PMID: 16753017.
      Citations: 50     Fields:    Translation:Animals
    75. Sun L, Peng Y, Sharrow AC, Iqbal J, Zhang Z, Papachristou DJ, Zaidi S, Zhu LL, Yaroslavskiy BB, Zhou H, Zallone A, Sairam MR, Kumar TR, Bo W, Braun J, Cardoso-Landa L, Schaffler MB, Moonga BS, Blair HC, Zaidi M. FSH directly regulates bone mass. Cell. 2006 Apr 21; 125(2):247-60. PMID: 16630814.
      Citations: 333     Fields:    Translation:HumansAnimalsCells
    76. Yang Li C, Majeska RJ, Laudier DM, Mann R, Schaffler MB. High-dose risedronate treatment partially preserves cancellous bone mass and microarchitecture during long-term disuse. Bone. 2005 Sep; 37(3):287-95. PMID: 16006205.
      Citations: 24     Fields:    Translation:Animals
    77. Li CY, Schaffler MB, Wolde-Semait HT, Hernandez CJ, Jepsen KJ. Genetic background influences cortical bone response to ovariectomy. J Bone Miner Res. 2005 Dec; 20(12):2150-8. PMID: 16294268.
      Citations: 43     Fields:    Translation:Animals
    78. Wang L, Wang Y, Han Y, Henderson SC, Majeska RJ, Weinbaum S, Schaffler MB. In situ measurement of solute transport in the bone lacunar-canalicular system. Proc Natl Acad Sci U S A. 2005 Aug 16; 102(33):11911-6. PMID: 16087872.
      Citations: 84     Fields:    Translation:AnimalsCells
    79. Tommasini SM, Nasser P, Schaffler MB, Jepsen KJ. Relationship between bone morphology and bone quality in male tibias: implications for stress fracture risk. J Bone Miner Res. 2005 Aug; 20(8):1372-80. PMID: 16007335.
      Citations: 53     Fields:    Translation:Humans
    80. Han Y, Cowin SC, Schaffler MB, Weinbaum S. Mechanotransduction and strain amplification in osteocyte cell processes. Proc Natl Acad Sci U S A. 2004 Nov 23; 101(47):16689-94. PMID: 15539460.
      Citations: 134     Fields:    Translation:HumansAnimalsCells
    81. Li CY, Price C, Delisser K, Nasser P, Laudier D, Clement M, Jepsen KJ, Schaffler MB. Long-term disuse osteoporosis seems less sensitive to bisphosphonate treatment than other osteoporosis. J Bone Miner Res. 2005 Jan; 20(1):117-24. PMID: 15619677.
      Citations: 32     Fields:    Translation:Animals
    82. You LD, Weinbaum S, Cowin SC, Schaffler MB. Ultrastructure of the osteocyte process and its pericellular matrix. Anat Rec A Discov Mol Cell Evol Biol. 2004 Jun; 278(2):505-13. PMID: 15164337.
      Citations: 125     Fields:    Translation:AnimalsCells
    83. McCreadie BR, Hollister SJ, Schaffler MB, Goldstein SA. Osteocyte lacuna size and shape in women with and without osteoporotic fracture. J Biomech. 2004 Apr; 37(4):563-72. PMID: 14996569.
      Citations: 57     Fields:    Translation:HumansCells
    84. Akkus O, Adar F, Schaffler MB. Age-related changes in physicochemical properties of mineral crystals are related to impaired mechanical function of cortical bone. Bone. 2004 Mar; 34(3):443-53. PMID: 15003792.
      Citations: 135     Fields:    Translation:Animals
    85. Schaffler MB. Role of bone turnover in microdamage. Osteoporos Int. 2003 Sep; 14 Suppl 5:S73-7; discussion S77-80. PMID: 14504710.
      Citations: 25     Fields:    Translation:Humans
    86. Akkus O, Polyakova-Akkus A, Adar F, Schaffler MB. Aging of microstructural compartments in human compact bone. J Bone Miner Res. 2003 Jun; 18(6):1012-9. PMID: 12817753.
      Citations: 62     Fields:    Translation:Humans
    87. Verborgt O, Tatton NA, Majeska RJ, Schaffler MB. Spatial distribution of Bax and Bcl-2 in osteocytes after bone fatigue: complementary roles in bone remodeling regulation? J Bone Miner Res. 2002 May; 17(5):907-14. PMID: 12009022.
      Citations: 68     Fields:    Translation:AnimalsCells
    88. Yeni YN, Schaffler MB, Gibson G, Fyhrie DP. Prestress due to dimensional changes caused by demineralization: a potential mechanism for microcracking in bone. Ann Biomed Eng. 2002 Feb; 30(2):217-25. PMID: 11962773.
      Citations: 9     Fields:    Translation:HumansAnimals
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