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Jon-Paul Bingham, PhD

TitleAssociate Professor
Faculty RankAssociate Professor
InstitutionUniversity of Hawaii at Manoa
DepartmentMolecular Bioscience and Bioengineering
AddressCollege of Tropical Agriculture and Human Resources
University of Hawaii at Mānoa
1800 East-West Road
Honolulu HI 96822
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Marabella M, Howard J, Bhandari S, Do S, Montoya-Pimolwatana M, Dou Y, Dobhal S, Arizala D, Montesinos S, Andreason SA, Ochoa-Corona F, Bingham JP, Odani J, Jenkins D, Ma LM, Fletcher J, Stack JP, Arif M. Genome guided LAMP assay for rapid and reliable detection of Xanthomonas axonopodis pv. vasculorum. Sci Rep. 2025 Jul 02; 15(1):23093. PMID: 40595234.
      Citations:    Fields:    Translation:AnimalsCells
    2. Bartlett B, Stitt-Bergh M, Kantar M, Bingham JP. A data science practicum to introduce undergraduate students to bioinformatics for research. Biochem Mol Biol Educ. 2023 Sep-Oct; 51(5):520-528. PMID: 37401749.
      Citations: 1     Fields:    Translation:Humans
    3. Espiritu MJ, Taylor JK, Sugai CK, Thapa P, Loening NM, Gusman E, Baoanan ZG, Baumann MH, Bingham JP. Characterization of the Native Disulfide Isomers of the Novel ?-Conotoxin PnID: Implications for Further Increasing Conotoxin Diversity. Mar Drugs. 2023 Jan 19; 21(2). PMID: 36827103.
      Citations: 3     Fields:    Translation:Animals
    4. DeLude A, Wells R, Boomla S, Chuang SC, Urena F, Shipman A, Rubas N, Kuehu DL, Bickerton B, Peterson T, Dobhal S, Arizala D, Klair D, Ochoa-Corona F, Ali ME, Odani J, Bingham JP, Jenkins DM, Fletcher J, Stack JP, Alvarez AM, Arif M. Loop-mediated isothermal amplification (LAMP) assay for specific and rapid detection of Dickeya fangzhongdai targeting a unique genomic region. Sci Rep. 2022 11 10; 12(1):19193. PMID: 36357509.
      Citations: 2     Fields:    Translation:AnimalsCells
    5. Wiere S, Sugai C, Espiritu MJ, Aurelio VP, Reyes CD, Yuzon N, Whittal RM, Tytgat J, Peigneur S, Bingham JP. Research into the Bioengineering of a Novel a-Conotoxin from the Milked Venom of Conus obscurus. Int J Mol Sci. 2022 Oct 11; 23(20). PMID: 36292948.
      Citations:    Fields:    Translation:Animals
    6. Domingo R, Perez C, Klair D, Vu H, Candelario-Tochiki A, Wang X, Camson A, Uy JN, Salameh M, Arizala D, Dobhal S, Boluk G, Bingham JP, Ochoa-Corona F, Ali ME, Stack JP, Fletcher J, Odani J, Jenkins D, Alvarez AM, Arif M. Genome-informed loop-mediated isothermal amplification assay for specific detection of Pectobacterium parmentieri in infected potato tissues and soil. Sci Rep. 2021 11 09; 11(1):21948. PMID: 34753982.
      Citations: 7     Fields:    Translation:AnimalsCellsPHPublic Health
    7. Laczko R, Chang A, Watanabe L, Petelo M, Kahaleua K, Bingham JP, Csiszar K. Anti-inflammatory activities of Waltheria indica extracts by modulating expression of IL-1B, TNF-a, TNFRII and NF-?B in human macrophages. Inflammopharmacology. 2020 Apr; 28(2):525-540. PMID: 31686273.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    8. Oeser SG, Bingham JP, Collier AC. Regulation of Hepatic UGT2B15 by Methylation in Adults of Asian Descent. Pharmaceutics. 2018 Jan 07; 10(1). PMID: 29316660.
      Citations:    
    9. Zhang RY, Thapa P, Espiritu MJ, Menon V, Bingham JP. From nature to creation: Going around in circles, the art of peptide cyclization. Bioorg Med Chem. 2018 03 15; 26(6):1135-1150. PMID: 29295762.
      Citations: 15     Fields:    Translation:AnimalsCells
    10. Pan C, McInnes G, Deflaux N, Snyder M, Bingham J, Datta S, Tsao PS. Cloud-based interactive analytics for terabytes of genomic variants data. Bioinformatics. 2017 Dec 01; 33(23):3709-3715. PMID: 28961771.
      Citations: 4     Fields:    Translation:Humans
    11. C Yuen RK, Merico D, Bookman M, L Howe J, Thiruvahindrapuram B, Patel RV, Whitney J, Deflaux N, Bingham J, Wang Z, Pellecchia G, Buchanan JA, Walker S, Marshall CR, Uddin M, Zarrei M, Deneault E, D'Abate L, Chan AJ, Koyanagi S, Paton T, Pereira SL, Hoang N, Engchuan W, Higginbotham EJ, Ho K, Lamoureux S, Li W, MacDonald JR, Nalpathamkalam T, Sung WW, Tsoi FJ, Wei J, Xu L, Tasse AM, Kirby E, Van Etten W, Twigger S, Roberts W, Drmic I, Jilderda S, Modi BM, Kellam B, Szego M, Cytrynbaum C, Weksberg R, Zwaigenbaum L, Woodbury-Smith M, Brian J, Senman L, Iaboni A, Doyle-Thomas K, Thompson A, Chrysler C, Leef J, Savion-Lemieux T, Smith IM, Liu X, Nicolson R, Seifer V, Fedele A, Cook EH, Dager S, Estes A, Gallagher L, Malow BA, Parr JR, Spence SJ, Vorstman J, Frey BJ, Robinson JT, Strug LJ, Fernandez BA, Elsabbagh M, Carter MT, Hallmayer J, Knoppers BM, Anagnostou E, Szatmari P, Ring RH, Glazer D, Pletcher MT, Scherer SW. Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder. Nat Neurosci. 2017 Apr; 20(4):602-611. PMID: 28263302.
      Citations: 416     Fields:    Translation:Humans
    12. Thapa P, Cabalteja CC, Philips EE, Espiritu MJ, Peigneur S, Mille BG, Tytgat J, Cummins TR, Bingham JP. t-boc synthesis of huwentoxin-i through native chemical ligation incorporating a trifluoromethanesulfonic acid cleavage strategy. Biopolymers. 2016 Sep; 106(5):737-45. PMID: 27271997.
      Citations:    Fields:    
    13. Yuen RK, Merico D, Cao H, Pellecchia G, Alipanahi B, Thiruvahindrapuram B, Tong X, Sun Y, Cao D, Zhang T, Wu X, Jin X, Zhou Z, Liu X, Nalpathamkalam T, Walker S, Howe JL, Wang Z, MacDonald JR, Chan A, D'Abate L, Deneault E, Siu MT, Tammimies K, Uddin M, Zarrei M, Wang M, Li Y, Wang J, Wang J, Yang H, Bookman M, Bingham J, Gross SS, Loy D, Pletcher M, Marshall CR, Anagnostou E, Zwaigenbaum L, Weksberg R, Fernandez BA, Roberts W, Szatmari P, Glazer D, Frey BJ, Ring RH, Xu X, Scherer SW. Genome-wide characteristics of de novo mutations in autism. NPJ Genom Med. 2016 Aug 03; 1:160271-1602710. PMID: 27525107.
      Citations:    
    14. Halford ZA, Yu PY, Likeman RK, Hawley-Molloy JS, Thomas C, Bingham JP. Cone shell envenomation: epidemiology, pharmacology and medical care. Diving Hyperb Med. 2015 Sep; 45(3):200-7. PMID: 26415072.
      Citations: 4     Fields:    Translation:HumansAnimals
    15. Maldonado A, Johnson A, Gochfeld D, Slattery M, Ostrander GK, Bingham JP, Schlenk D. Hard coral (Porites lobata) extracts and homarine on cytochrome P450 expression in Hawaiian butterflyfishes with different feeding strategies. Comp Biochem Physiol C Toxicol Pharmacol. 2016 Jan; 179:57-63. PMID: 26297807.
      Citations: 2     Fields:    Translation:AnimalsCells
    16. Thapa P, Zhang RY, Menon V, Bingham JP. Native chemical ligation: a boon to peptide chemistry. Molecules. 2014 Sep 12; 19(9):14461-83. PMID: 25221869.
      Citations: 21     Fields:    Translation:Humans
    17. Thapa P, Espiritu MJ, Cabalteja CC, Bingham JP. Conotoxins and their regulatory considerations. Regul Toxicol Pharmacol. 2014 Oct; 70(1):197-202. PMID: 25013992.
      Citations: 5     Fields:    Translation:HumansAnimals
    18. Yafuso JT, Negi VS, Bingham JP, Borthakur D. An O-acetylserine (thiol) lyase from Leucaena leucocephala is a cysteine synthase but not a mimosine synthase. Appl Biochem Biotechnol. 2014 Jul; 173(5):1157-68. PMID: 24777760.
      Citations: 3     Fields:    Translation:AnimalsCells
    19. Espiritu MJ, Collier AC, Bingham JP. A 21st-century approach to age-old problems: the ascension of biologics in clinical therapeutics. Drug Discov Today. 2014 Aug; 19(8):1109-13. PMID: 24480607.
      Citations: 11     Fields:    Translation:HumansAnimals
    20. Takacs Z, Imredy JP, Bingham JP, Zhorov BS, Moczydlowski EG. Interaction of the BKCa channel gating ring with dendrotoxins. Channels (Austin). 2014; 8(5):421-32. PMID: 25483585.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    21. Negi VS, Bingham JP, Li QX, Borthakur D. A carbon-nitrogen lyase from Leucaena leucocephala catalyzes the first step of mimosine degradation. Plant Physiol. 2014 Feb; 164(2):922-34. PMID: 24351687.
      Citations: 12     Fields:    Translation:AnimalsCells
    22. Espiritu MJ, Cabalteja CC, Sugai CK, Bingham JP. Incorporation of post-translational modified amino acids as an approach to increase both chemical and biological diversity of conotoxins and conopeptides. Amino Acids. 2014 Jan; 46(1):125-51. PMID: 24221351.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    23. Bergeron ZL, Chun JB, Baker MR, Sandall DW, Peigneur S, Yu PY, Thapa P, Milisen JW, Tytgat J, Livett BG, Bingham JP. A 'conovenomic' analysis of the milked venom from the mollusk-hunting cone snail Conus textile--the pharmacological importance of post-translational modifications. Peptides. 2013 Nov; 49:145-58. PMID: 24055806.
      Citations: 7     Fields:    Translation:AnimalsCells
    24. Kapono CA, Thapa P, Cabalteja CC, Guendisch D, Collier AC, Bingham JP. Conotoxin truncation as a post-translational modification to increase the pharmacological diversity within the milked venom of Conus magus. Toxicon. 2013 Aug; 70:170-8. PMID: 23668937.
      Citations: 9     Fields:    Translation:AnimalsCells
    25. Negi VS, Bingham JP, Li QX, Borthakur D. midD-encoded 'rhizomimosinase' from Rhizobium sp. strain TAL1145 is a C-N lyase that catabolizes L-mimosine into 3-hydroxy-4-pyridone, pyruvate and ammonia. Amino Acids. 2013 Jun; 44(6):1537-47. PMID: 23462928.
      Citations: 5     Fields:    Translation:Cells
    26. Bergeron ZL, Bingham JP. Scorpion toxins specific for potassium (K+) channels: a historical overview of peptide bioengineering. Toxins (Basel). 2012 Nov 01; 4(11):1082-119. PMID: 23202307.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    27. Bingham JP, Andrews EA, Kiyabu SM, Cabalteja CC. Drugs from slugs. Part II--conopeptide bioengineering. Chem Biol Interact. 2012 Dec 05; 200(2-3):92-113. PMID: 23063744.
      Citations: 6     Fields:    Translation:Animals
    28. Bingham JP, Baker MR, Chun JB. Analysis of a cone snail's killer cocktail--the milked venom of Conus geographus. Toxicon. 2012 Nov; 60(6):1166-70. PMID: 22884604.
      Citations: 8     Fields:    Translation:AnimalsCells
    29. Chun JB, Baker MR, Kim DH, Leroy M, Toribo P, Bingham JP. Cone snail milked venom dynamics--a quantitative study of Conus purpurascens. Toxicon. 2012 Jul; 60(1):83-94. PMID: 22497788.
      Citations: 13     Fields:    Translation:AnimalsCells
    30. Bingham JP, Mitsunaga E, Bergeron ZL. Drugs from slugs--past, present and future perspectives of omega-conotoxin research. Chem Biol Interact. 2010 Jan 05; 183(1):1-18. PMID: 19800874.
      Citations: 28     Fields:    Translation:AnimalsCells
    31. Bingham JP, Chun JB, Ruzicka MR, Li QX, Tan ZY, Kaulin YA, Englebretsen DR, Moczydlowski EG. Synthesis of an iberiotoxin derivative by chemical ligation: a method for improved yields of cysteine-rich scorpion toxin peptides. Peptides. 2009 Jun; 30(6):1049-57. PMID: 19463736.
      Citations: 4     Fields:    Translation:HumansCells
    32. Xiao Y, Bingham JP, Zhu W, Moczydlowski E, Liang S, Cummins TR. Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain ii voltage sensor in the closed configuration. J Biol Chem. 2008 Oct 03; 283(40):27300-13. PMID: 18628201.
      Citations: 91     Fields:    Translation:HumansAnimalsCells
    33. Bingham JP, Bian S, Tan ZY, Takacs Z, Moczydlowski E. Synthesis of a biotin derivative of iberiotoxin: binding interactions with streptavidin and the BK Ca2+-activated K+ channel expressed in a human cell line. Bioconjug Chem. 2006 May-Jun; 17(3):689-99. PMID: 16704206.
      Citations: 11     Fields:    Translation:HumansCells
    34. Krishnan MN, Bingham JP, Lee SH, Trombley P, Moczydlowski E. Functional role and affinity of inorganic cations in stabilizing the tetrameric structure of the KcsA K+ channel. J Gen Physiol. 2005 Sep; 126(3):271-83. PMID: 16129774.
      Citations: 22     Fields:    Translation:Cells
    35. Bingham JP, Broxton NM, Livett BG, Down JG, Jones A, Moczydlowski EG. Optimizing the connectivity in disulfide-rich peptides: alpha-conotoxin SII as a case study. Anal Biochem. 2005 Mar 01; 338(1):48-61. PMID: 15707935.
      Citations: 3     Fields:    Translation:AnimalsCells
    36. Jakubowski JA, Keays DA, Kelley WP, Sandall DW, Bingham JP, Livett BG, Gayler KR, Sweedler JV. Determining sequences and post-translational modifications of novel conotoxins in Conus victoriae using cDNA sequencing and mass spectrometry. J Mass Spectrom. 2004 May; 39(5):548-57. PMID: 15170751.
      Citations: 21     Fields:    Translation:AnimalsCells
    37. Duda TF, Bingham JP, Livett BG, Kohn AJ, Massilia GR, Schultz JR, Down J, Sandall D, Sweedler JV. How much at risk are cone snails? Science. 2004 Feb 13; 303(5660):955-7; author reply 955-7. PMID: 14963310.
      Citations: 3     Fields:    Translation:Animals
    38. Marshall J, Kelley WP, Rubakhin SS, Bingham JP, Sweedler JV, Gilly WF. Anatomical correlates of venom production in Conus californicus. Biol Bull. 2002 Aug; 203(1):27-41. PMID: 12200253.
      Citations: 24     Fields:    Translation:Animals
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